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Stk10 serine/threonine kinase 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29398, updated on 18-Sep-2024

Summary

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Official Symbol
Stk10provided by RGD
Official Full Name
serine/threonine kinase 10provided by RGD
Primary source
RGD:3779
See related
EnsemblRapid:ENSRNOG00000004217 AllianceGenome:RGD:3779
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein homodimerization activity and protein serine/threonine kinase activity. Predicted to be involved in lymphocyte aggregation; protein autophosphorylation; and regulation of lymphocyte migration. Predicted to be located in plasma membrane. Orthologous to human STK10 (serine/threonine kinase 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 158.9), Thymus (RPKM 139.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Stk10 in Genome Data Viewer
Location:
10q12
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (17622149..17716337)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (17117860..17212065)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (17420964..17521810)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ubiquitin domain containing 2 Neighboring gene EF-hand calcium binding domain 9 Neighboring gene uncharacterized LOC120095062 Neighboring gene uncharacterized LOC120095061 Neighboring gene F-box and WD repeat domain containing 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The identification of a novel cDNA preferentially expressed in the olfactory-limbic system of the adult rat. Schaar DG, et al. Brain Res, 1996 May 20. PMID 8793103
  2. Deficiency of a STE20/PAK family kinase LOK leads to the acceleration of LFA-1 clustering and cell adhesion of activated lymphocytes. Endo J, et al. FEBS Lett, 2000 Feb 25. PMID 10692593
  3. Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue. Walter SA, et al. J Biol Chem, 2003 May 16. PMID 12639966
  4. LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation. Belkina NV, et al. Proc Natl Acad Sci U S A, 2009 Mar 24. PMID 19255442, Free PMC Article
  5. Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites. Pike AC, et al. EMBO J, 2008 Feb 20. PMID 18239682, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. VIRMA promotes neuron apoptosis via inducing m6A methylation of STK10 in spinal cord injury animal models.
    Title: VIRMA promotes neuron apoptosis via inducing m6A methylation of STK10 in spinal cord injury animal models.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lymphocyte aggregation IEA
Inferred from Electronic Annotation
more info
  
involved_in lymphocyte aggregation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of lymphocyte migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of lymphocyte migration IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of lymphocyte migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of lymphocyte migration ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase 10
NP_062079.2
XP_038941664.1
XP_038941665.1
XP_063124879.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019206.2 → NP_062079.2  serine/threonine-protein kinase 10

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    H9KVF6
    Related
    ENSRNOP00000044325.5, ENSRNOT00000047011.6
    Conserved Domains (3) summary
    cd06644
    Location:23 → 314
    STKc_STK10; Catalytic domain of the Serine/Threonine Kinase, STK10 (also called Lymphocyte-Oriented Kinase or LOK)
    smart00220
    Location:36 → 294
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12474
    Location:768 → 908
    PKK; Polo kinase kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    17622149..17716337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085736.2 → XP_038941664.1  serine/threonine-protein kinase 10 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K7Z9, H9KVF6
    Related
    ENSRNOP00000074413.2, ENSRNOT00000080404.3
    Conserved Domains (2) summary
    cd06644
    Location:23 → 314
    STKc_STK10; Catalytic domain of the Serine/Threonine Kinase, STK10 (also called Lymphocyte-Oriented Kinase or LOK)
    pfam12474
    Location:600 → 738
    PKK; Polo kinase kinase

  2. XM_063268809.1 → XP_063124879.1  serine/threonine-protein kinase 10 isoform X2

    UniProtKB/TrEMBL
    H9KVF6

  3. XM_039085737.2 → XP_038941665.1  serine/threonine-protein kinase 10 isoform X3

    UniProtKB/TrEMBL
    H9KVF6
    Conserved Domains (2) summary
    pfam12474
    Location:494 → 632
    PKK; Polo kinase kinase
    cl21453
    Location:2 → 208
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9PTG8.1 GenPept UniProtKB/Swiss-Prot:E9PTG8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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