U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Stk10 serine/threonine kinase 10 [ Mus musculus (house mouse) ]

Gene ID: 20868, updated on 14-May-2024

Summary

Official Symbol
Stk10provided by MGI
Official Full Name
serine/threonine kinase 10provided by MGI
Primary source
MGI:MGI:1099439
See related
Ensembl:ENSMUSG00000020272 AllianceGenome:MGI:1099439
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lok; Gek1; mKIAA4026
Summary
This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. Mice deficient for this gene product are viable, but exhibit altered integrin-mediated lymphocyte adhesion characteristics. The orthologous gene product in humans can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen adult (RPKM 37.1), testis adult (RPKM 17.2) and 20 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Stk10 in Genome Data Viewer
Location:
11 18.97 cM; 11 A4
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (32483266..32574595)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (32533266..32624595)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ubiquitin domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E11474 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:32442680-32442833 Neighboring gene EF-hand calcium binding domain 9 Neighboring gene STARR-positive B cell enhancer ABC_E5214 Neighboring gene F-box and WD-40 domain protein 11 Neighboring gene STARR-seq mESC enhancer starr_29115 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA4026

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in lymphocyte aggregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of lymphocyte migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of lymphocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of lymphocyte migration ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase 10
Names
germ cell kinase 1
lymphocyte-oriented kinase
NP_001346106.1
NP_001346107.1
NP_033314.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359177.1NP_001346106.1  serine/threonine-protein kinase 10 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AL669844, BC096624
  2. NM_001359178.1NP_001346107.1  serine/threonine-protein kinase 10 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 3, which has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK148118, AL669844, BC096624, BY207613
  3. NM_009288.2NP_033314.2  serine/threonine-protein kinase 10 isoform 1

    See identical proteins and their annotated locations for NP_033314.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA182088, AL669844, BC096624, BC128363, BY207613
    Consensus CDS
    CCDS24529.1
    UniProtKB/Swiss-Prot
    B1ATW8, O55098
    UniProtKB/TrEMBL
    A1A553
    Related
    ENSMUSP00000099885.4, ENSMUST00000102821.4
    Conserved Domains (3) summary
    cd06644
    Location:23314
    STKc_STK10; Catalytic domain of the Serine/Threonine Kinase, STK10 (also called Lymphocyte-Oriented Kinase or LOK)
    smart00220
    Location:36294
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12474
    Location:754894
    PKK; Polo kinase kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    32483266..32574595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)