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SSU72 SSU72 homolog, RNA polymerase II CTD phosphatase [ Homo sapiens (human) ]

Gene ID: 29101, updated on 1-Mar-2024

Summary

Official Symbol
SSU72provided by HGNC
Official Full Name
SSU72 homolog, RNA polymerase II CTD phosphataseprovided by HGNC
Primary source
HGNC:HGNC:25016
See related
Ensembl:ENSG00000160075 MIM:617680; AllianceGenome:HGNC:25016
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSPC182; PNAS-120
Summary
Enables RNA polymerase II CTD heptapeptide repeat phosphatase activity. Involved in dephosphorylation of RNA polymerase II C-terminal domain and mRNA polyadenylation. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 50.5), fat (RPKM 49.2) and 25 other tissues See more
Orthologs
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Genomic context

See SSU72 in Genome Data Viewer
Location:
1p36.33
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1541673..1574863, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (976177..1009369, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1477053..1510243, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 77 Neighboring gene ATPase family AAA domain containing 3A Neighboring gene Sharpr-MPRA regulatory region 185 Neighboring gene transmembrane protein 240 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1505865-1506366 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 78 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 79 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:1511866-1512035 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1512434-1512976 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1529354-1530202 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 80 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1534010-1534668 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1534669-1535328 Neighboring gene uncharacterized LOC105378586 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1535329-1535988 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1535989-1536648 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:1537005-1537147 Neighboring gene fibronectin type III domain containing 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 83 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 84 Neighboring gene uncharacterized LOC124903821 Neighboring gene MIB E3 ubiquitin protein ligase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1565596-1566158

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of SSU72 RNA polymerase II CTD phosphatase homolog by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat recruits Ssu72 together with P-TEFb to the integrated HIV-1 proviral promoter in TNF-alpha treated 2D10 T cells PubMed
tat Ssu72 cooperates with the Tat/P-TEFb complex to create a CTD that is highly enriched in S2 phosphorylation PubMed
tat Ssu72 stimulates HIV-1 Tat transactivation in a C-terminal domain phosphatase-dependent manner PubMed
tat HIV-1 Tat interacts directly with the human Ssu72 CTD phosphatase and both the N-terminal and the C-terminal domains of Tat, and the coiled-coil domain of Ssu72 are required for the direct interaction between Tat and Ssu72 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ13048

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
part_of mRNA cleavage and polyadenylation specificity factor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
RNA polymerase II subunit A C-terminal domain phosphatase SSU72
Names
CTD phosphatase SSU72
NP_054907.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014188.3NP_054907.1  RNA polymerase II subunit A C-terminal domain phosphatase SSU72

    See identical proteins and their annotated locations for NP_054907.1

    Status: VALIDATED

    Source sequence(s)
    AF161530, AJ276409, CF594026
    Consensus CDS
    CCDS32.1
    UniProtKB/Swiss-Prot
    Q9BZS6, Q9H933, Q9NP77
    UniProtKB/TrEMBL
    B4DMK6
    Related
    ENSP00000291386.3, ENST00000291386.4
    Conserved Domains (1) summary
    pfam04722
    Location:6194
    Ssu72; Ssu72-like protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    1541673..1574863 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    976177..1009369 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)