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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_011987.2 RefSeqGene
- Range
-
47409..231162
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001092.5 → NP_001083.2 active breakpoint cluster region-related protein isoform b
See identical proteins and their annotated locations for NP_001083.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
- Source sequence(s)
-
AC015884, AK124547, AK126882, AK127851, AK295191, AL135250, DA106008, DA327723
- Consensus CDS
-
CCDS11000.1
- UniProtKB/Swiss-Prot
-
Q12979
- UniProtKB/TrEMBL
- B7Z2X0, Q6ZT60
- Related
- ENSP00000291107.2, ENST00000291107.6
- Conserved Domains (4) summary
-
- cd08686
Location:469 → 589
- C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
- cd00160
Location:55 → 245
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd04387
Location:608 → 803
- RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...
- cd13366
Location:240 → 423
- PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
-
NM_001159746.3 → NP_001153218.1 active breakpoint cluster region-related protein isoform c
See identical proteins and their annotated locations for NP_001153218.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter than isoform a. Variants 3 and 6 encode the same isoform (c).
- Source sequence(s)
-
AC015884, AC016292, AK124547, AK126882, AK127851, AK302682, AL135250, DA327723
- Consensus CDS
-
CCDS54060.1
- UniProtKB/Swiss-Prot
-
Q12979
- UniProtKB/TrEMBL
- B7Z7Z1, Q6ZT60
- Related
- ENSP00000442048.2, ENST00000544583.6
- Conserved Domains (4) summary
-
- cd08686
Location:460 → 580
- C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
- cd00160
Location:46 → 236
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd04387
Location:599 → 794
- RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...
- cd13366
Location:231 → 414
- PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
-
NM_001256847.3 → NP_001243776.1 active breakpoint cluster region-related protein isoform d
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) differs in the 5' UTR, lacks a large portion of the coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a.
- Source sequence(s)
-
AC015884, AK124547, AK126882, AK127851, AK299909, AK300336, AL135250, HY132628
- Consensus CDS
-
CCDS58497.1
- UniProtKB/Swiss-Prot
-
Q12979
- UniProtKB/TrEMBL
- B7Z683, Q6ZT60
- Related
- ENSP00000445198.2, ENST00000543210.6
- Conserved Domains (2) summary
-
- cd04387
Location:96 → 291
- RhoGAP_Bcr; RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, ...
- cl14603
Location:49 → 77
- C2; C2 domain
-
NM_001282149.2 → NP_001269078.1 active breakpoint cluster region-related protein isoform e
See identical proteins and their annotated locations for NP_001269078.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (e) has a distinct N-terminus and is shorter than isoform a.
- Source sequence(s)
-
AC015884, AK124547, AK126882, AK127851, AK299909, AK302682, AL135250, DA327723
- Consensus CDS
-
CCDS73936.1
- UniProtKB/Swiss-Prot
-
Q12979
- UniProtKB/TrEMBL
- B7Z683, B7Z7Z1, Q6ZT60
- Related
- ENSP00000437429.2, ENST00000536794.6
- Conserved Domains (4) summary
-
- cd08686
Location:288 → 408
- C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
- cd04387
Location:427 → 622
- RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...
- cd13366
Location:59 → 242
- PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
- cl02571
Location:17 → 64
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
-
NM_001322840.2 → NP_001309769.1 active breakpoint cluster region-related protein isoform c
Status: REVIEWED
- Source sequence(s)
-
AC015884, AC016292
- Consensus CDS
-
CCDS54060.1
- UniProtKB/Swiss-Prot
-
Q12979
- Related
- ENSP00000461565.2, ENST00000574437.5
- Conserved Domains (4) summary
-
- cd08686
Location:460 → 580
- C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
- cd00160
Location:46 → 236
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd04387
Location:599 → 794
- RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...
- cd13366
Location:231 → 414
- PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
-
NM_001322841.2 → NP_001309770.1 active breakpoint cluster region-related protein isoform f
Status: REVIEWED
- Description
- Transcript Variant: This variant (7) initiates from an upstream promoter and differs in the 5' UTR and 5' coding region compared to variant 1. The encoded isoform (f) has distinct N-terminus and is longer than isoform a.
- Source sequence(s)
-
AC015884, AC144836, AK126882, AK127851, AK302682, AL135250, BE675741, BM547076
- UniProtKB/TrEMBL
- B7Z7Z1, Q6ZT60
- Related
- ENSP00000461629.3, ENST00000574139.7
-
NM_001322842.2 → NP_001309771.1 active breakpoint cluster region-related protein isoform g
Status: REVIEWED
- Description
- Transcript Variant: This variant (8) differs in the 3' coding region and 3' UTR and lacks multiple 3' coding exons compared to variant 1. The encoded isoform (g) has a distinct N- and C- termini and is shorter than isoform a.
- Source sequence(s)
-
AC144836
- Conserved Domains (1) summary
-
- pfam09036
Location:3 → 65
- Bcr-Abl_Oligo; Bcr-Abl oncoprotein oligomerization domain
-
NM_021962.5 → NP_068781.2 active breakpoint cluster region-related protein isoform a
See identical proteins and their annotated locations for NP_068781.2
Status: REVIEWED
- Source sequence(s)
-
AC015884, AC016292, AK124547, AK126882, AK127851, AK302682, AL135250, DA327723, DR003682, HY115199, HY133863, U01147
- Consensus CDS
-
CCDS10999.1
- UniProtKB/Swiss-Prot
-
Q12979
- UniProtKB/TrEMBL
- B7Z7Z1, Q6ZT60
- Related
- ENSP00000303909.5, ENST00000302538.10
- Conserved Domains (4) summary
-
- cd08686
Location:506 → 626
- C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
- cd00160
Location:92 → 282
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd04387
Location:645 → 840
- RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...
- cd13366
Location:277 → 460
- PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000017.11 Reference GRCh38.p14 Primary Assembly
- Range
-
1003519..1229722 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_047435860.1 → XP_047291816.1 active breakpoint cluster region-related protein isoform X3
-
XM_017024540.3 → XP_016880029.1 active breakpoint cluster region-related protein isoform X2
-
XM_017024539.2 → XP_016880028.1 active breakpoint cluster region-related protein isoform X1
-
XM_047435864.1 → XP_047291820.1 active breakpoint cluster region-related protein isoform X11
-
XM_011523814.4 → XP_011522116.1 active breakpoint cluster region-related protein isoform X11
See identical proteins and their annotated locations for XP_011522116.1
- Conserved Domains (4) summary
-
- cd08686
Location:460 → 580
- C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
- cd04387
Location:599 → 813
- RhoGAP_Bcr; RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, ...
- cd13366
Location:231 → 414
- PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
- pfam00621
Location:49 → 237
- RhoGEF; RhoGEF domain
-
XM_047435863.1 → XP_047291819.1 active breakpoint cluster region-related protein isoform X7
-
XM_011523810.4 → XP_011522112.1 active breakpoint cluster region-related protein isoform X6
See identical proteins and their annotated locations for XP_011522112.1
- Conserved Domains (4) summary
-
- cd08686
Location:506 → 626
- C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
- cd00160
Location:92 → 282
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd04387
Location:645 → 859
- RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...
- cd13366
Location:277 → 460
- PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
-
XM_011523815.4 → XP_011522117.1 active breakpoint cluster region-related protein isoform X11
See identical proteins and their annotated locations for XP_011522117.1
- Conserved Domains (4) summary
-
- cd08686
Location:460 → 580
- C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
- cd04387
Location:599 → 813
- RhoGAP_Bcr; RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, ...
- cd13366
Location:231 → 414
- PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
- pfam00621
Location:49 → 237
- RhoGEF; RhoGEF domain
-
XM_011523813.4 → XP_011522115.1 active breakpoint cluster region-related protein isoform X10
See identical proteins and their annotated locations for XP_011522115.1
- Conserved Domains (4) summary
-
- cd08686
Location:469 → 589
- C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
- cd04387
Location:608 → 822
- RhoGAP_Bcr; RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, ...
- cd13366
Location:240 → 423
- PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
- pfam00621
Location:58 → 246
- RhoGEF; RhoGEF domain
-
XM_011523812.4 → XP_011522114.1 active breakpoint cluster region-related protein isoform X9
See identical proteins and their annotated locations for XP_011522114.1
- Conserved Domains (4) summary
-
- cd08686
Location:493 → 613
- C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
- cd04387
Location:632 → 846
- RhoGAP_Bcr; RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, ...
- cd13366
Location:264 → 447
- PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
- pfam00621
Location:82 → 270
- RhoGEF; RhoGEF domain
-
XM_047435865.1 → XP_047291821.1 active breakpoint cluster region-related protein isoform X12
-
XM_017024543.3 → XP_016880032.1 active breakpoint cluster region-related protein isoform X14
-
XM_017024542.3 → XP_016880031.1 active breakpoint cluster region-related protein isoform X13
-
XM_047435862.1 → XP_047291818.1 active breakpoint cluster region-related protein isoform X5
-
XM_047435861.1 → XP_047291817.1 active breakpoint cluster region-related protein isoform X4
-
XM_011523811.4 → XP_011522113.2 active breakpoint cluster region-related protein isoform X8
RNA
-
XR_007065294.1 RNA Sequence
Reference GRCh38.p14 ALT_REF_LOCI_1
Genomic
-
NT_187613.1 Reference GRCh38.p14 ALT_REF_LOCI_1
- Range
-
42766..231744 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Reference GRCh38.p14 ALT_REF_LOCI_2
Genomic
-
NT_187664.1 Reference GRCh38.p14 ALT_REF_LOCI_2
- Range
-
42766..153205 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate T2T-CHM13v2.0
Genomic
-
NC_060941.1 Alternate T2T-CHM13v2.0
- Range
-
890209..1120740 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)