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Abr active BCR-related gene [ Mus musculus (house mouse) ]

Gene ID: 109934, updated on 5-Mar-2024

Summary

Official Symbol
Abrprovided by MGI
Official Full Name
active BCR-related geneprovided by MGI
Primary source
MGI:MGI:107771
See related
Ensembl:ENSMUSG00000017631 AllianceGenome:MGI:107771
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables GTPase activator activity. Involved in several processes, including negative regulation of blood vessel remodeling; negative regulation of cellular extravasation; and regulation of vascular permeability. Acts upstream of or within several processes, including neuromuscular process controlling balance; regulation of vesicle-mediated transport; and response to lipopolysaccharide. Located in cytosol; glutamatergic synapse; and plasma membrane. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including alimentary system; mesothelium; metanephros; nervous system; and sensory organ. Orthologous to human ABR (ABR activator of RhoGEF and GTPase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 53.0), cortex adult (RPKM 47.8) and 23 other tissues See more
Orthologs
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Genomic context

Location:
11 B5; 11 45.92 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (76307560..76468515, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (76416732..76623324, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30020 Neighboring gene nucleoredoxin Neighboring gene STARR-seq mESC enhancer starr_30022 Neighboring gene STARR-seq mESC enhancer starr_30023 Neighboring gene STARR-seq mESC enhancer starr_30026 Neighboring gene STARR-positive B cell enhancer ABC_E9828 Neighboring gene STARR-positive B cell enhancer ABC_E3976 Neighboring gene STARR-positive B cell enhancer ABC_E7020 Neighboring gene translocase of inner mitochondrial membrane 22 Neighboring gene STARR-seq mESC enhancer starr_30035 Neighboring gene predicted gene 12341 Neighboring gene STARR-seq mESC enhancer starr_30037 Neighboring gene predicted gene, 53687 Neighboring gene STARR-seq mESC enhancer starr_30041 Neighboring gene ribosomal protein L36, pseudogene 2 Neighboring gene breakpoint cluster region pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • 6330400K15Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activator activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activator activity TAS
Traceable Author Statement
more info
PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in activation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within brain development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of establishment of localization in cell IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within inner ear morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of macrophage migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of blood vessel remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cellular extravasation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of macrophage migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of neutrophil degranulation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuromuscular process controlling balance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of neutrophil degranulation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of phagocytosis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of phagocytosis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of vascular permeability IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density, intracellular component ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
active breakpoint cluster region-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291186.2NP_001278115.1  active breakpoint cluster region-related protein isoform 4

    See identical proteins and their annotated locations for NP_001278115.1

    Status: VALIDATED

    Source sequence(s)
    AL591143, AL663050
    Consensus CDS
    CCDS70246.1
    UniProtKB/Swiss-Prot
    Q5SSL4
    Related
    ENSMUSP00000068982.8, ENSMUST00000065028.14
    Conserved Domains (4) summary
    cd08686
    Location:288408
    C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
    cd04387
    Location:427622
    RhoGAP_Bcr; RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, ...
    cd13366
    Location:59242
    PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
    cl02571
    Location:1765
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
  2. NM_001346670.2NP_001333599.1  active breakpoint cluster region-related protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL591143, AL663050
    Consensus CDS
    CCDS83843.1
    UniProtKB/Swiss-Prot
    Q5SSL4
    Related
    ENSMUSP00000104045.3, ENSMUST00000108408.9
  3. NM_001363379.2NP_001350308.1  active breakpoint cluster region-related protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL663050
    Conserved Domains (2) summary
    cd04387
    Location:102297
    RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...
    cl14603
    Location:5583
    C2; C2 domain
  4. NM_198018.3NP_932135.1  active breakpoint cluster region-related protein isoform 1

    See identical proteins and their annotated locations for NP_932135.1

    Status: VALIDATED

    Source sequence(s)
    AL591143, AL663050
    Consensus CDS
    CCDS36231.1
    UniProtKB/TrEMBL
    A0A2X0U2A7
    Related
    ENSMUSP00000091551.5, ENSMUST00000094012.11
    Conserved Domains (4) summary
    cd08686
    Location:518638
    C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
    cd00160
    Location:104294
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd04387
    Location:657852
    RhoGAP_Bcr; RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, ...
    cd13366
    Location:289472
    PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
  5. NM_198894.3NP_942597.1  active breakpoint cluster region-related protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL591143, AL663050
    Consensus CDS
    CCDS25067.1
    UniProtKB/TrEMBL
    E9PUE7
    Conserved Domains (4) summary
    cd08686
    Location:460580
    C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
    cd04387
    Location:599794
    RhoGAP_Bcr; RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, ...
    cd13366
    Location:231414
    PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
    pfam00621
    Location:49237
    RhoGEF; RhoGEF domain
  6. NM_198895.3NP_942598.1  active breakpoint cluster region-related protein isoform 3

    See identical proteins and their annotated locations for NP_942598.1

    Status: VALIDATED

    Source sequence(s)
    AL591143, AL663050
    Consensus CDS
    CCDS25066.1
    UniProtKB/Swiss-Prot
    Q3U5G0, Q3UQJ6, Q3UY38, Q5SSL4, Q5SYJ5, Q5SYJ7, Q5SYJ8, Q5SYJ9, Q6PCY1, Q6PDH3
    Related
    ENSMUSP00000072522.7, ENSMUST00000072740.13
    Conserved Domains (4) summary
    cd08686
    Location:506626
    C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
    cd04387
    Location:645840
    RhoGAP_Bcr; RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, ...
    cd13366
    Location:277460
    PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
    pfam00621
    Location:95283
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    76307560..76468515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245469.1XP_030101329.1  active breakpoint cluster region-related protein isoform X1

    Conserved Domains (4) summary
    cd08686
    Location:473593
    C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
    cd00160
    Location:84249
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd04387
    Location:612807
    RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...
    cd13366
    Location:244427
    PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
  2. XM_036156228.1XP_036012121.1  active breakpoint cluster region-related protein isoform X2

    Conserved Domains (3) summary
    cd00160
    Location:92282
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13366
    Location:277460
    PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
    cl14603
    Location:506597
    C2; C2 domain