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DCPS decapping enzyme, scavenger [ Homo sapiens (human) ]

Gene ID: 28960, updated on 27-Nov-2024

Summary

Official Symbol
DCPSprovided by HGNC
Official Full Name
decapping enzyme, scavengerprovided by HGNC
Primary source
HGNC:HGNC:29812
See related
Ensembl:ENSG00000110063 MIM:610534; AllianceGenome:HGNC:29812
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARS; DCS1; HSL1; HINT5; HINT-5; HSPC015
Summary
This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5′ mRNA cap structure, which appear in the 3′ → 5′ mRNA decay pathway, following deadenylation and exosome-mediated turnover. This enzyme hydrolyzes the triphosphate linkage of the cap structure (7-methylguanosine nucleoside triphosphate) to yield 7-methylguanosine monophosphate and nucleoside diphosphate. It protects the cell from the potentially toxic accumulation of these short, capped mRNA fragments, and regulates the activity of other cap-binding proteins, which are inhibited by their accumulation. It also acts as a transcript-specific modulator of pre-mRNA splicing and microRNA turnover. [provided by RefSeq, Apr 2017]
Expression
Ubiquitous expression in lymph node (RPKM 6.1), gall bladder (RPKM 5.3) and 25 other tissues See more
Orthologs
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Genomic context

See DCPS in Genome Data Viewer
Location:
11q24.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (126304060..126350005)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (126335487..126381408)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (126173955..126219900)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902838 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126152727-126153534 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5706 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126162703-126163207 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4049 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5708 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:126185709-126185914 Neighboring gene TIRAP antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126197556-126198280 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126198281-126199003 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:126203043-126203544 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:126204673-126205174 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126206322-126206884 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126206885-126207448 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126207449-126208010 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:126208933-126210132 Neighboring gene TIR domain containing adaptor protein Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:126224473-126225216 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126225217-126225958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126225959-126226702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126228189-126228930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126234481-126234998 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126263623-126264550 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 4 Neighboring gene Sharpr-MPRA regulatory region 5906 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4052 Neighboring gene G-quadruplex forming sequence containing lncRNA Neighboring gene ReSE screen-validated silencer GRCh37_chr11:126304382-126304547 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126306384-126307384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126312444-126313126 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126314549-126315102 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126315103-126315656 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126316770-126317338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126336189-126336738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126336739-126337286 Neighboring gene kirre like nephrin family adhesion molecule 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126348793-126349294 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126356175-126356675 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126364262-126365032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126389731-126390232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126393473-126393972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126398704-126399204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126399205-126399705 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126413360-126413866 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126413867-126414371 Neighboring gene KIRREL3 antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:126434244-126434929 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126437665-126438165 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:126455626-126456345 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:126456346-126457066 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:126457067-126457785 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126462463-126462992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126462993-126463521 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:126471727-126472504 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr11:126477093-126477778 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr11:126477779-126478464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:126478465-126479149

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: TIRAP

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA 7-methylguanosine cap binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA 7-methylguanosine cap binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA exonuclease activity TAS
Traceable Author Statement
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
m7GpppX diphosphatase
Names
5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase
decapping scavenger enzyme
epididymis secretory sperm binding protein
heat shock-like protein 1
hint-related 7meGMP-directed hydrolase
histidine triad nucleotide-binding protein 5
histidine triad protein member 5
homolog of C. elegans 7meGMP-directed hydrolase dcs-1
mRNA decapping enzyme
scavenger mRNA-decapping enzyme DcpS
NP_001337165.1
NP_054745.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053153.1 RefSeqGene

    Range
    5760..51705
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001350236.2NP_001337165.1  m7GpppX diphosphatase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF532613, AP001318, AY040771, BE382749, BM998313
    UniProtKB/TrEMBL
    Q53G42
    Conserved Domains (1) summary
    cl27009
    Location:47336
    DcpS; Scavenger mRNA decapping enzyme (DcpS) N-terminal
  2. NM_014026.6NP_054745.1  m7GpppX diphosphatase isoform 2

    See identical proteins and their annotated locations for NP_054745.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AF532613, AP001318, AY040771, BE382749, BM998313
    Consensus CDS
    CCDS8473.1
    UniProtKB/Swiss-Prot
    Q8NHL8, Q96C86, Q9Y2S5
    UniProtKB/TrEMBL
    A0A384MTI8, Q53G42
    Related
    ENSP00000263579.4, ENST00000263579.5
    Conserved Domains (1) summary
    COG5075
    Location:47329
    COG5075; Uncharacterized conserved protein [Function unknown]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    126304060..126350005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    126335487..126381408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)