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DCPS decapping enzyme, scavenger [ Homo sapiens (human) ]

Gene ID: 28960, updated on 13-Mar-2020

Summary

Official Symbol
DCPSprovided by HGNC
Official Full Name
decapping enzyme, scavengerprovided by HGNC
Primary source
HGNC:HGNC:29812
See related
Ensembl:ENSG00000110063 MIM:610534
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARS; DCS1; HSL1; HINT5; HINT-5; HSPC015
Summary
This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5′ mRNA cap structure, which appear in the 3′ → 5′ mRNA decay pathway, following deadenylation and exosome-mediated turnover. This enzyme hydrolyzes the triphosphate linkage of the cap structure (7-methylguanosine nucleoside triphosphate) to yield 7-methylguanosine monophosphate and nucleoside diphosphate. It protects the cell from the potentially toxic accumulation of these short, capped mRNA fragments, and regulates the activity of other cap-binding proteins, which are inhibited by their accumulation. It also acts as a transcript-specific modulator of pre-mRNA splicing and microRNA turnover. [provided by RefSeq, Apr 2017]
Expression
Ubiquitous expression in lymph node (RPKM 6.1), gall bladder (RPKM 5.3) and 25 other tissues See more
Orthologs

Genomic context

See DCPS in Genome Data Viewer
Location:
11q24.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (126304060..126350005)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (126173647..126215644)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L35a pseudogene 26 Neighboring gene TIR domain containing adaptor protein Neighboring gene uncharacterized HP11014 Neighboring gene G-quadruplex forming sequence containing lncRNA Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 4 Neighboring gene Sharpr-MPRA regulatory region 5906

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: TIRAP

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA 7-methylguanosine cap binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA 7-methylguanosine cap binding IDA
Inferred from Direct Assay
more info
PubMed 
exoribonuclease activity TAS
Traceable Author Statement
more info
 
m7G(5')pppN diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
m7G(5')pppN diphosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
P-body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
m7GpppX diphosphatase
Names
5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase
decapping scavenger enzyme
epididymis secretory sperm binding protein
heat shock-like protein 1
hint-related 7meGMP-directed hydrolase
histidine triad nucleotide-binding protein 5
histidine triad protein member 5
homolog of C. elegans 7meGMP-directed hydrolase dcs-1
mRNA decapping enzyme
scavenger mRNA-decapping enzyme DcpS
NP_001337165.1
NP_054745.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053153.1 RefSeqGene

    Range
    5760..51705
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001350236.2NP_001337165.1  m7GpppX diphosphatase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF532613, AP001318, AY040771, BE382749, BM998313
    Conserved Domains (1) summary
    cl27009
    Location:47336
    DcpS; Scavenger mRNA decapping enzyme (DcpS) N-terminal
  2. NM_014026.6NP_054745.1  m7GpppX diphosphatase isoform 2

    See identical proteins and their annotated locations for NP_054745.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AF532613, AP001318, AY040771, BE382749, BM998313
    Consensus CDS
    CCDS8473.1
    UniProtKB/Swiss-Prot
    Q96C86
    Related
    ENSP00000263579.4, ENST00000263579.5
    Conserved Domains (1) summary
    cl27009
    Location:47329
    DcpS; Scavenger mRNA decapping enzyme (DcpS) N-terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    126304060..126350005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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