U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dcps decapping enzyme, scavenger [ Mus musculus (house mouse) ]

Gene ID: 69305, updated on 8-Dec-2022

Summary

Official Symbol
Dcpsprovided by MGI
Official Full Name
decapping enzyme, scavengerprovided by MGI
Primary source
MGI:MGI:1916555
See related
Ensembl:ENSMUSG00000032040 AllianceGenome:MGI:1916555
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DCS-1; HINT-5; 1700001E16Rik
Summary
Predicted to enable RNA 7-methylguanosine cap binding activity; identical protein binding activity; and m7G(5')pppN diphosphatase activity. Predicted to be involved in cellular response to menadione; mRNA metabolic process; and negative regulation of programmed cell death. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Predicted to be active in P-body and nucleus. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; nervous system; and sensory organ. Orthologous to human DCPS (decapping enzyme, scavenger). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14.5 (RPKM 26.3), liver E14 (RPKM 24.3) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Dcps in Genome Data Viewer
Location:
9; 9 A4
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (35035710..35087283, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (35124414..35175987, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 4 Neighboring gene predicted gene, 51705 Neighboring gene RIKEN cDNA 4930581F22 gene Neighboring gene uncharacterized LOC115487216 Neighboring gene predicted gene, 24262 Neighboring gene toll-interleukin 1 receptor (TIR) domain-containing adaptor protein Neighboring gene predicted gene, 39318 Neighboring gene FAD-dependent oxidoreductase domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA 7-methylguanosine cap binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA 7-methylguanosine cap binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables m7G(5')pppN diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables m7G(5')pppN diphosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to menadione ISO
Inferred from Sequence Orthology
more info
 
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA cis splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in methylguanosine-cap decapping ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
m7GpppX diphosphatase
Names
decapping scavenger enzyme
hint-related 7meGMP-directed hydrolase
histidine triad nucleotide-binding protein 5
histidine triad protein member 5
mRNA decapping enzyme
scavenger mRNA-decapping enzyme DcpS
NP_081306.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027030.2NP_081306.1  m7GpppX diphosphatase

    See identical proteins and their annotated locations for NP_081306.1

    Status: PROVISIONAL

    Source sequence(s)
    AK005584
    Consensus CDS
    CCDS22957.1
    UniProtKB/Swiss-Prot
    Q8C5I7, Q9DAR7
    Related
    ENSMUSP00000034539.6, ENSMUST00000034539.12
    Conserved Domains (3) summary
    COG5075
    Location:46320
    COG5075; Uncharacterized conserved protein [Function unknown]
    pfam05652
    Location:44145
    DcpS; Scavenger mRNA decapping enzyme (DcpS) N-terminal
    pfam11969
    Location:174281
    DcpS_C; Scavenger mRNA decapping enzyme C-term binding

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    35035710..35087283 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)