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TIRAP TIR domain containing adaptor protein [ Homo sapiens (human) ]

Gene ID: 114609, updated on 23-Nov-2021

Summary

Official Symbol
TIRAPprovided by HGNC
Official Full Name
TIR domain containing adaptor proteinprovided by HGNC
Primary source
HGNC:HGNC:17192
See related
Ensembl:ENSG00000150455 MIM:606252
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Mal; wyatt; BACTS1; MyD88-2
Summary
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
Annotation information
Note: MAL (Gene ID: 4118), TIRAP (Gene ID: 114609), and MKL1 (Gene ID: 57591) share the MAL symbol/alias in common. MAL is a widely used alternative name for TIR domain containing adaptor protein (TIRAP) and megakaryoblastic leukemia (translocation) 1 (MKL1). [23 May 2018]
Expression
Ubiquitous expression in duodenum (RPKM 2.7), ovary (RPKM 2.6) and 25 other tissues See more
Orthologs
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Genomic context

See TIRAP in Genome Data Viewer
Location:
11q24.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (126283093..126294933)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (126152988..126164828)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene FAD dependent oxidoreductase domain containing 1 Neighboring gene ribosomal protein L35a pseudogene 26 Neighboring gene uncharacterized HP11014 Neighboring gene decapping enzyme, scavenger Neighboring gene G-quadruplex forming sequence containing lncRNA Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat causes proteasomal degradation of TIRAP and NFKBIA in THP-1 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: DCPS

Homology

Clone Names

  • FLJ42305

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
 
enables Toll-like receptor 2 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables Toll-like receptor 2 binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables Toll-like receptor 4 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables Toll-like receptor 4 binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase C binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA stabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in MyD88-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in TIRAP-dependent toll-like receptor 4 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of NF-kappaB-inducing kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell surface receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to bacterial lipopeptide ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to lipoteichoic acid ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in defense response to Gram-positive bacterium ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in myeloid cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of B cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of chemokine (C-X-C motif) ligand 1 production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of interleukin-12 production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of interleukin-15 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-8 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neutrophil chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of toll-like receptor 2 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of toll-like receptor 3 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of toll-like receptor 4 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of innate immune response IC
Inferred by Curator
more info
PubMed 
involved_in regulation of interferon-beta production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of stress-activated MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in ruffle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
toll/interleukin-1 receptor domain-containing adapter protein
Names
MyD88 adapter-like protein
Toll-like receptor adaptor protein
adapter protein wyatt
adaptor protein Wyatt
toll-interleukin 1 receptor (TIR) domain containing adaptor protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011523.1 RefSeqGene

    Range
    5001..16847
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001039661.2NP_001034750.1  toll/interleukin-1 receptor domain-containing adapter protein isoform a

    See identical proteins and their annotated locations for NP_001034750.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longer transcript but encodes the shorter isoform (a). Variants 3 and 5 both encode the same isoform (a).
    Source sequence(s)
    AK124298, AP001318, BC032474
    Consensus CDS
    CCDS8472.1
    UniProtKB/Swiss-Prot
    P58753
    UniProtKB/TrEMBL
    A0A024R3M4
    Related
    ENSP00000376447.2, ENST00000392680.6
    Conserved Domains (1) summary
    pfam13676
    Location:88208
    TIR_2; TIR domain
  2. NM_001318776.2NP_001305705.1  toll/interleukin-1 receptor domain-containing adapter protein isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 2. Variants 2 and 4 both encode the same isoform (b).
    Source sequence(s)
    AF378129, AK124298, AK313147
    Consensus CDS
    CCDS41731.1
    UniProtKB/Swiss-Prot
    P58753
    Conserved Domains (1) summary
    pfam13676
    Location:88208
    TIR_2; TIR domain
  3. NM_001318777.2NP_001305706.1  toll/interleukin-1 receptor domain-containing adapter protein isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. Variants 3 and 5 both encode the same isoform (a).
    Source sequence(s)
    AK124298, AP001318, AY576785
    Consensus CDS
    CCDS8472.1
    UniProtKB/Swiss-Prot
    P58753
    UniProtKB/TrEMBL
    A0A024R3M4
    Related
    ENSP00000376446.1, ENST00000392679.6
    Conserved Domains (1) summary
    pfam13676
    Location:88208
    TIR_2; TIR domain
  4. NM_148910.3NP_683708.1  toll/interleukin-1 receptor domain-containing adapter protein isoform b

    See identical proteins and their annotated locations for NP_683708.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an additional segment within the 5' UTR and differs in the 3' coding region and 3' UTR, compared to variant 3. This results in a longer isoform (b) with a distinct C-terminus, compared to isoform a. Variants 2 and 4 both encode the same isoform (b).
    Source sequence(s)
    AF378129, AK124298
    Consensus CDS
    CCDS41731.1
    UniProtKB/Swiss-Prot
    P58753
    Related
    ENSP00000376445.3, ENST00000392678.7
    Conserved Domains (1) summary
    pfam13676
    Location:88208
    TIR_2; TIR domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    126283093..126294933
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_052887.2: Suppressed sequence

    Description
    NM_052887.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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