Format

Send to:

Choose Destination

GRID1 glutamate ionotropic receptor delta type subunit 1 [ Homo sapiens (human) ]

Gene ID: 2894, updated on 12-Aug-2018

Summary

Official Symbol
GRID1provided by HGNC
Official Full Name
glutamate ionotropic receptor delta type subunit 1provided by HGNC
Primary source
HGNC:HGNC:4575
See related
Ensembl:ENSG00000182771 MIM:610659; Vega:OTTHUMG00000018650
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GluD1
Summary
This gene encodes a subunit of glutamate receptor channels. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.[provided by RefSeq, Jan 2009]
Expression
Biased expression in brain (RPKM 6.7), thyroid (RPKM 3.7) and 12 other tissues See more
Orthologs

Genomic context

See GRID1 in Genome Data Viewer
Location:
10q23.1-q23.2
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (85599555..86366493, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (87359312..88126250, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1520 Neighboring gene uncharacterized LOC105378404 Neighboring gene RNA, U6 small nuclear 325, pseudogene Neighboring gene GRID1 antisense RNA 1 Neighboring gene RNA, 7SK small nuclear pseudogene 238 Neighboring gene RNA, 5S ribosomal pseudogene 322 Neighboring gene microRNA 346 Neighboring gene uncharacterized LOC105378408 Neighboring gene uncharacterized LOC105378407 Neighboring gene RNA, U6 small nuclear 780, pseudogene Neighboring gene WAPL cohesin release factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2011-12-21)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2011-12-21)

ClinGen Genome Curation Page

NHGRI GWAS Catalog

Description
A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.
NHGRI GWA Catalog
Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data.
NHGRI GWA Catalog
Genetic variants associated with disordered eating.
NHGRI GWA Catalog
Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder.
NHGRI GWA Catalog
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
NHGRI GWA Catalog
Genome-wide association study of periodontal pathogen colonization.
NHGRI GWA Catalog
Genome-wide association study of survival in patients with pancreatic adenocarcinoma.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1220

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ionotropic glutamate receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
ionotropic glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
social behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
glutamate receptor ionotropic, delta-1
Names
gluR delta-1 subunit
glutamate receptor delta-1 subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011875.1 RefSeqGene

    Range
    5001..771939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_017551.2NP_060021.1  glutamate receptor ionotropic, delta-1 precursor

    See identical proteins and their annotated locations for NP_060021.1

    Status: REVIEWED

    Source sequence(s)
    AB033046, AK127168, AK293104, DR001156
    Consensus CDS
    CCDS31236.1
    UniProtKB/Swiss-Prot
    Q9ULK0
    UniProtKB/TrEMBL
    A8KAN9
    Related
    ENSP00000330148.7, OTTHUMP00000020003, ENST00000327946.11, OTTHUMT00000049148
    Conserved Domains (4) summary
    cd06392
    Location:25423
    PBP1_iGluR_delta_1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the delta1 receptor of an orphan glutamate receptor family
    cd13730
    Location:436806
    PBP2_iGluR_delta_1; The ligand-binding domain of an orphan ionotropic glutamate receptor delta-1, a member of the type 2 periplasmic-binding fold protein superfamily
    pfam00060
    Location:564841
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:41400
    ANF_receptor; Receptor family ligand binding region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    85599555..86366493 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539720.2XP_011538022.1  glutamate receptor ionotropic, delta-1 isoform X1

    Related
    ENSP00000433064.1, OTTHUMP00000020002, ENST00000464741.2, OTTHUMT00000049147
    Conserved Domains (4) summary
    cd06392
    Location:25423
    PBP1_iGluR_delta_1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the delta1 receptor of an orphan glutamate receptor family
    cd13730
    Location:436806
    PBP2_iGluR_delta_1; The ligand-binding domain of an orphan ionotropic glutamate receptor delta-1, a member of the type 2 periplasmic-binding fold protein superfamily
    pfam00060
    Location:564841
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:41400
    ANF_receptor; Receptor family ligand binding region
Support Center