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Grid1 glutamate receptor, ionotropic, delta 1 [ Mus musculus (house mouse) ]

Gene ID: 14803, updated on 8-May-2024

Summary

Official Symbol
Grid1provided by MGI
Official Full Name
glutamate receptor, ionotropic, delta 1provided by MGI
Primary source
MGI:MGI:95812
See related
Ensembl:ENSMUSG00000041078 AllianceGenome:MGI:95812
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GluD1; GluRdelta1
Summary
Predicted to enable glutamate receptor activity; identical protein binding activity; and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Involved in social behavior. Located in glutamatergic synapse. Is integral component of postsynaptic density membrane. Is expressed in several structures, including alimentary system; brain; liver and biliary system; reproductive system; and spinal cord. Orthologous to human GRID1 (glutamate ionotropic receptor delta type subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 4.3), frontal lobe adult (RPKM 4.0) and 11 other tissues See more
Orthologs
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Genomic context

See Grid1 in Genome Data Viewer
Location:
14 B; 14 20.84 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (34541751..35305344)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (34820003..35583387)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930038B10 gene Neighboring gene STARR-seq mESC enhancer starr_36402 Neighboring gene STARR-seq mESC enhancer starr_36403 Neighboring gene predicted gene, 52101 Neighboring gene predicted gene, 30969 Neighboring gene microRNA 346 Neighboring gene STARR-seq mESC enhancer starr_36406 Neighboring gene predicted gene, 41133 Neighboring gene STARR-seq mESC enhancer starr_36407 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_36408 Neighboring gene STARR-seq mESC enhancer starr_36409 Neighboring gene STARR-seq mESC enhancer starr_36410 Neighboring gene STARR-seq mESC enhancer starr_36411 Neighboring gene RIKEN cDNA 4930596D02 gene Neighboring gene sorting nexin 15 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glutamate receptor ionotropic, delta-1
Names
gluR delta-1 subunit
glutamate receptor delta-1 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008166.2NP_032192.2  glutamate receptor ionotropic, delta-1 precursor

    See identical proteins and their annotated locations for NP_032192.2

    Status: VALIDATED

    Source sequence(s)
    AC154730, AK138279, BM899969, DN176234
    Consensus CDS
    CCDS26944.1
    UniProtKB/Swiss-Prot
    Q3UUL5, Q61627
    Related
    ENSMUSP00000044009.6, ENSMUST00000043349.7
    Conserved Domains (2) summary
    cd06392
    Location:25423
    PBP1_iGluR_delta_1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the delta1 receptor of an orphan glutamate receptor family
    cd13730
    Location:436806
    PBP2_iGluR_delta_1; The ligand-binding domain of an orphan ionotropic glutamate receptor delta-1, a member of the type 2 periplasmic-binding fold protein superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    34541751..35305344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244962.4XP_011243264.1  glutamate receptor ionotropic, delta-1 isoform X2

    Conserved Domains (2) summary
    cd13730
    Location:436806
    PBP2_iGluR_delta_1; The ligand-binding domain of an orphan ionotropic glutamate receptor delta-1, a member of the type 2 periplasmic-binding fold protein superfamily
    cd06392
    Location:25425
    PBP1_iGluR_delta_1; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the delta1 receptor of an orphan glutamate receptor family
  2. XM_006518565.4XP_006518628.1  glutamate receptor ionotropic, delta-1 isoform X1

    Conserved Domains (2) summary
    cd13730
    Location:341711
    PBP2_iGluR_delta_1; The ligand-binding domain of an orphan ionotropic glutamate receptor delta-1, a member of the type 2 periplasmic-binding fold protein superfamily
    cl10011
    Location:25330
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
  3. XM_006518566.4XP_006518629.1  glutamate receptor ionotropic, delta-1 isoform X3

    Conserved Domains (2) summary
    cd13730
    Location:225595
    PBP2_iGluR_delta_1; The ligand-binding domain of an orphan ionotropic glutamate receptor delta-1, a member of the type 2 periplasmic-binding fold protein superfamily
    cl10011
    Location:1214
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily