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GRIA1 glutamate ionotropic receptor AMPA type subunit 1 [ Homo sapiens (human) ]

Gene ID: 2890, updated on 2-Mar-2021

Summary

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Official Symbol
GRIA1provided by HGNC
Official Full Name
glutamate ionotropic receptor AMPA type subunit 1provided by HGNC
Primary source
HGNC:HGNC:4571
See related
Ensembl:ENSG00000155511 MIM:138248
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLUH1; GLUR1; GLURA; GluA1; HBGR1
Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 23.3) and lung (RPKM 3.7) See more
Orthologs
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Genomic context

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See GRIA1 in Genome Data Viewer
Location:
5q33.2
Exon count:
20
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (153490670..153813873)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (152870230..153193429)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene tRNA-Cys (anticodon ACA) 1-1 Neighboring gene long intergenic non-protein coding RNA 1470 Neighboring gene RNA, 7SL, cytoplasmic 177, pseudogene Neighboring gene long intergenic non-protein coding RNA 1861 Neighboring gene uncharacterized LOC107986464

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Emerging role of AMPA receptor subunit GluA1 in synaptic plasticity: Implications for Alzheimer's disease. Qu W, et al. Cell Prolif, 2021 Jan. PMID 33188547, Free PMC Article
  2. M1 muscarinic receptors regulate the phosphorylation of AMPA receptor subunit GluA1 via a signaling pathway linking cAMP-PKA and PI3K-Akt. Zhao LX, et al. FASEB J, 2019 May. PMID 30794430
  3. Quantitative assessment of the association between GRIA1 polymorphisms and migraine risk. Gao X, et al. Biosci Rep, 2018 Dec 21. PMID 30446525, Free PMC Article
  4. Amygdala levels of the GluA1 subunit of glutamate receptors and its phosphorylation state at serine 845 in the anterior hippocampus are biomarkers of ictal fear but not anxiety. Leal RB, et al. Mol Psychiatry, 2020 Mar. PMID 29880883
  5. Kinetic and Thermodynamic Evaluation of Kynurenic Acid Binding to GluR1270-300 Polypeptide by Surface Plasmon Resonance Experiments. Juhász Á, et al. J Phys Chem B, 2016 Aug 18. PMID 27459050

See all (137) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Emerging role of AMPA receptor subunit GluA1 in synaptic plasticity: Implications for Alzheimer's disease.
    Title: Emerging role of AMPA receptor subunit GluA1 in synaptic plasticity: Implications for Alzheimer's disease.
  2. Amygdala levels of the GluA1 subunit of glutamate receptors and its phosphorylation state at serine 845 in the anterior hippocampus are biomarkers of ictal fear but not anxiety.
    Title: Amygdala levels of the GluA1 subunit of glutamate receptors and its phosphorylation state at serine 845 in the anterior hippocampus are biomarkers of ictal fear but not anxiety.
  3. these data demonstrate that M1 receptor activation induces membrane insertion of GluA1 via a signaling linking cAMP-PKA and PI3K-Akt-mTOR pathways but is irrelevant to protein synthesis.
    Title: M1 muscarinic receptors regulate the phosphorylation of AMPA receptor subunit GluA1 <i>via</i> a signaling pathway linking cAMP-PKA and PI3K-Akt.
  4. Nanoscale mobility of resting AMPA receptors predetermines responsiveness to neurotransmitter, allosteric anions and TARP auxiliary subunits. Mobility at rest is regulated by alternative splicing of the flip/flop cassette of the ligand-binding domain, which controls motions in the distant AMPA receptor N-terminal domain (NTD).
    Title: Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors.
  5. These findings suggest that AKAP79, by orchestrating phosphorylation, represents a key to a GluA1 phosphorylation passcode, which allows the GluA1 subunit to escape GluA2 dominance and promote the appearance of CP-AMPARs.
    Title: Preferential generation of Ca<sup>2+</sup>-permeable AMPA receptors by AKAP79-anchored protein kinase C proceeds via GluA1 subunit phosphorylation at Ser-831.
  6. These results indicate that GRIA1 rs2195450 C>T polymorphism is significantly associated with migraine risk.
    Title: Quantitative assessment of the association between <i>GRIA1</i> polymorphisms and migraine risk.
  7. Results found higher activating GluA1 phosphorylation at Serine 845 in brain samples from epileptic patients and provided evidence that GluA1 phosphorylation is modulated by GSK3B.
    Title: GSK3β activity alleviates epileptogenesis and limits GluA1 phosphorylation.
  8. These findings indicate that the CaMKII-mediated GluA1 phosphorylation of S567 and S831 is critical for P2X2-mediated AMPAR internalization and ATP-driven synaptic depression.
    Title: P2X-mediated AMPA receptor internalization and synaptic depression is controlled by two CaMKII phosphorylation sites on GluA1 in hippocampal neurons.
  9. The reversible binding of kynurenic acid (KYNA) on human glutamate receptor (GluR1) polypeptide (GluR1270-300)-modified gold surface has been studied at various temperatures under physiological conditions by two-dimensional SPR experiments. The registered sensorgrams were fitted by using different kinetic models without application of any commercial software. Results suggested that the binding reaction was exothermic.
    Title: Kinetic and Thermodynamic Evaluation of Kynurenic Acid Binding to GluR1270-300 Polypeptide by Surface Plasmon Resonance Experiments.
  10. Elevated GluA1 expression in spinal cord of the amyotrophic lateral sclerosis patients.
    Title: C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca<sup>2+</sup>-permeable AMPA receptor-mediated excitotoxicity.
Submit: New GeneRIF Correction See all GeneRIFs (61)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
A genome-wide association study of aging.
GeneReviews: Not available
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available
Genetic variations in GRIA1 on chromosome 5q33 related to asparaginase hypersensitivity.
GeneReviews: Not available
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
GeneReviews: Not available
Genome-wide association study of anthropometric traits in Korcula Island, Croatia.
GeneReviews: Not available
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat The gene expression of glutamate receptor 1 is significantly upregulated in clade B Tat treated SK-N-MC neuroblastoma cells PubMed
tat HIV-1 Tat-induced dendritic swellings that act in striatal neurons are regulated by NMDA and AMPA receptor-related events PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC133252

Gene Ontology Provided by GOA

Function Evidence Code Pubs
AMPA glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
AMPA glutamate receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
PDZ domain binding ISS
Inferred from Sequence or Structural Similarity
more info
  
amyloid-beta binding ISS
Inferred from Sequence or Structural Similarity
more info
  
glutamate receptor activity TAS
Traceable Author Statement
more info
 PubMed 
ligand-gated ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
COPII vesicle coating TAS
Traceable Author Statement
more info
  
cellular response to ammonium ion IEA
Inferred from Electronic Annotation
more info
  
chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
endoplasmic reticulum to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
  
ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
ionotropic glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
long-term memory IEA
Inferred from Electronic Annotation
more info
  
long-term synaptic depression IEA
Inferred from Electronic Annotation
more info
  
receptor internalization IEA
Inferred from Electronic Annotation
more info
  
regulation of NMDA receptor activity TAS
Traceable Author Statement
more info
  
regulation of postsynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
  
regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
  
signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
AMPA glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
AMPA glutamate receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
  
ER to Golgi transport vesicle membrane TAS
Traceable Author Statement
more info
  
Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
axonal spine IEA
Inferred from Electronic Annotation
more info
  
cell surface ISS
Inferred from Sequence or Structural Similarity
more info
  
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
  
dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
  
dendritic spine membrane IDA
Inferred from Direct Assay
more info
 PubMed 
early endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
endocytic vesicle membrane TAS
Traceable Author Statement
more info
  
endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
endoplasmic reticulum-Golgi intermediate compartment membrane TAS
Traceable Author Statement
more info
  
excitatory synapse IEA
Inferred from Electronic Annotation
more info
  
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
integral component of postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
  
neuron spine ISS
Inferred from Sequence or Structural Similarity
more info
  
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
  
perisynaptic space IEA
Inferred from Electronic Annotation
more info
  
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
plasma membrane TAS
Traceable Author Statement
more info
  
postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
  
recycling endosome IDA
Inferred from Direct Assay
more info
 PubMed 
recycling endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
synaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glutamate receptor 1
Names
AMPA 1
AMPA-selective glutamate receptor 1
gluR-1
gluR-A
gluR-K1
glutamate receptor, ionotropic, AMPA 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047078.1 RefSeqGene

    Range
    5975..329174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000827.4 → NP_000818.2  glutamate receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_000818.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AB209094, AK310189, AL120214, DC335107, M81886, X58633
    Consensus CDS
    CCDS4322.1
    UniProtKB/Swiss-Prot
    P42261
    UniProtKB/TrEMBL
    Q59GL5
    Related
    ENSP00000285900.4, ENST00000285900.10
    Conserved Domains (2) summary
    cd13729
    Location:406 → 787
    PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06390
    Location:26 → 392
    PBP1_iGluR_AMPA_GluR1; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor

  2. NM_001114183.2 → NP_001107655.1  glutamate receptor 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001107655.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a different coding exon in the 3' region, as compared to variant 1. The resulting isoform (2) is the same length but has a different internal segment, as compared to isoform 1.
    Source sequence(s)
    AB209094, AL120214, DC335107, M64752
    Consensus CDS
    CCDS47318.1
    UniProtKB/Swiss-Prot
    P42261
    UniProtKB/TrEMBL
    Q59GL5
    Related
    ENSP00000339343.5, ENST00000340592.9
    Conserved Domains (2) summary
    cd13729
    Location:406 → 787
    PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06390
    Location:26 → 392
    PBP1_iGluR_AMPA_GluR1; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor

  3. NM_001258019.2 → NP_001244948.1  glutamate receptor 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001244948.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AB209094, AK295827, AL120214
    Consensus CDS
    CCDS58986.1
    UniProtKB/Swiss-Prot
    P42261
    UniProtKB/TrEMBL
    Q59GL5
    Related
    ENSP00000427920.1, ENST00000518142.5
    Conserved Domains (2) summary
    cd13729
    Location:326 → 707
    PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cl10011
    Location:26 → 312
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

  4. NM_001258020.2 → NP_001244949.1  glutamate receptor 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and has an alternate in-frame exon in place of another exon of the same size. The resulting isoform (4) is shorter at the N-terminus and has a different sequence (but same length) segment in the C-terminus compared to isoform 1.
    Source sequence(s)
    AB209094, AL120214, DC335107
    UniProtKB/TrEMBL
    Q59GL5
    Conserved Domains (4) summary
    cd13729
    Location:311 → 692
    PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:443 → 722
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:1 → 277
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:1 → 294
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

  5. NM_001258021.2 → NP_001244950.1  glutamate receptor 1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an alternate exon in place of the 5'-most exon of variant 1. The resulting isoform (5) has a longer and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AB209094, AK295184, AK295827, AK315934, AL120214
    Consensus CDS
    CCDS58987.1
    UniProtKB/Swiss-Prot
    P42261
    UniProtKB/TrEMBL
    Q59GL5
    Related
    ENSP00000428994.1, ENST00000518783.1
    Conserved Domains (4) summary
    cd06390
    Location:36 → 399
    PBP1_iGluR_AMPA_GluR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
    cd13729
    Location:416 → 797
    PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:548 → 827
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:47 → 382
    ANF_receptor; Receptor family ligand binding region

  6. NM_001258022.2 → NP_001244951.1  glutamate receptor 1 isoform 6

    See identical proteins and their annotated locations for NP_001244951.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has an alternate exon in place of the 5'-most exon of variant 1 and has an alternate in-frame exon in place of another exon of the same size. The resulting isoform (6) has a longer and distinct N-terminus and has a different sequence (but same length) segment in the C-terminus compared to isoform 1.
    Source sequence(s)
    AB209094, AK295184, AK315934, AL120214
    Consensus CDS
    CCDS58988.1
    UniProtKB/Swiss-Prot
    P42261
    UniProtKB/TrEMBL
    Q59GL5
    Related
    ENSP00000415569.2, ENST00000448073.8
    Conserved Domains (4) summary
    cd06390
    Location:36 → 399
    PBP1_iGluR_AMPA_GluR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
    cd13729
    Location:416 → 797
    PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:548 → 827
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:47 → 382
    ANF_receptor; Receptor family ligand binding region

  7. NM_001258023.1 → NP_001244952.1  glutamate receptor 1 isoform 7

    See identical proteins and their annotated locations for NP_001244952.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has an alternate exon in place of the 5'-most exon of variant 1. The resulting isoform (7) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AB209094, AK295039, AL120214
    Consensus CDS
    CCDS58989.1
    UniProtKB/Swiss-Prot
    P42261
    UniProtKB/TrEMBL
    Q59GL5
    Related
    ENSP00000427864.2, ENST00000521843.6
    Conserved Domains (2) summary
    cd13729
    Location:337 → 718
    PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cl10011
    Location:1 → 323
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

  8. NM_001364165.2 → NP_001351094.1  glutamate receptor 1 isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AC010613, AC091960, AC091962
    Conserved Domains (2) summary
    cd13729
    Location:350 → 731
    PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cl10011
    Location:26 → 336
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

  9. NM_001364166.2 → NP_001351095.1  glutamate receptor 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC010613, AC091960, AC091962
    Conserved Domains (2) summary
    cd06390
    Location:35 → 398
    PBP1_iGluR_AMPA_GluR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
    cd13729
    Location:415 → 796
    PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

  10. NM_001364167.2 → NP_001351096.1  glutamate receptor 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC010613, AC091960, AC091962
    Conserved Domains (2) summary
    cd13729
    Location:337 → 718
    PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cl10011
    Location:1 → 323
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

RNA

  1. NR_047578.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an alternate 5' exon and an alternate 3' exon compared to variant 1. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD) and is therefore thought to be non-protein coding.
    Source sequence(s)
    AB209094, AC091960, AK294011, AL120214

  2. NR_157093.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010613, AC091960, AC091962

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    153490670..153813873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009392.1 → XP_016864881.1  glutamate receptor 1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42261.2 GenPept UniProtKB/Swiss-Prot:P42261

Gene LinkOut

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