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GRIA1 glutamate ionotropic receptor AMPA type subunit 1 [ Homo sapiens (human) ]

Gene ID: 2890, updated on 23-Nov-2021

Summary

Official Symbol
GRIA1provided by HGNC
Official Full Name
glutamate ionotropic receptor AMPA type subunit 1provided by HGNC
Primary source
HGNC:HGNC:4571
See related
Ensembl:ENSG00000155511 MIM:138248
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLUH1; GLUR1; GLURA; GluA1; HBGR1
Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 23.3) and lung (RPKM 3.7) See more
Orthologs
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Genomic context

See GRIA1 in Genome Data Viewer
Location:
5q33.2
Exon count:
20
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (153490670..153813873)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (152870230..153193429)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene tRNA-Cys (anticodon ACA) 1-1 Neighboring gene long intergenic non-protein coding RNA 1470 Neighboring gene RNA, 7SL, cytoplasmic 177, pseudogene Neighboring gene long intergenic non-protein coding RNA 1861 Neighboring gene uncharacterized LOC107986464

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of aging.
GeneReviews: Not available
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available
Genetic variations in GRIA1 on chromosome 5q33 related to asparaginase hypersensitivity.
GeneReviews: Not available
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
GeneReviews: Not available
Genome-wide association study of anthropometric traits in Korcula Island, Croatia.
GeneReviews: Not available
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The gene expression of glutamate receptor 1 is significantly upregulated in clade B Tat treated SK-N-MC neuroblastoma cells PubMed
tat HIV-1 Tat-induced dendritic swellings that act in striatal neurons are regulated by NMDA and AMPA receptor-related events PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC133252

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables AMPA glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables AMPA glutamate receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables PDZ domain binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables amyloid-beta binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables glutamate receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables ligand-gated ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular response to ammonium ion IEA
Inferred from Electronic Annotation
more info
 
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in ionotropic glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in long-term memory IEA
Inferred from Electronic Annotation
more info
 
involved_in long-term synaptic depression IEA
Inferred from Electronic Annotation
more info
 
involved_in receptor internalization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of postsynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of AMPA glutamate receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in ER to Golgi transport vesicle membrane TAS
Traceable Author Statement
more info
 
located_in axonal spine IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dendritic spine membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum-Golgi intermediate compartment membrane TAS
Traceable Author Statement
more info
 
located_in excitatory synapse IEA
Inferred from Electronic Annotation
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron spine ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perisynaptic space IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in recycling endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in synaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glutamate receptor 1
Names
AMPA 1
AMPA-selective glutamate receptor 1
gluR-1
gluR-A
gluR-K1
glutamate receptor, ionotropic, AMPA 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047078.1 RefSeqGene

    Range
    5975..329174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000827.4NP_000818.2  glutamate receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_000818.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AB209094, AK310189, AL120214, DC335107, M81886, X58633
    Consensus CDS
    CCDS4322.1
    UniProtKB/Swiss-Prot
    P42261
    UniProtKB/TrEMBL
    Q59GL5
    Related
    ENSP00000285900.4, ENST00000285900.10
    Conserved Domains (2) summary
    cd13729
    Location:406787
    PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06390
    Location:26392
    PBP1_iGluR_AMPA_GluR1; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
  2. NM_001114183.2NP_001107655.1  glutamate receptor 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001107655.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a different coding exon in the 3' region, as compared to variant 1. The resulting isoform (2) is the same length but has a different internal segment, as compared to isoform 1.
    Source sequence(s)
    AB209094, AL120214, DC335107, M64752
    Consensus CDS
    CCDS47318.1
    UniProtKB/Swiss-Prot
    P42261
    UniProtKB/TrEMBL
    Q59GL5
    Related
    ENSP00000339343.5, ENST00000340592.9
    Conserved Domains (2) summary
    cd13729
    Location:406787
    PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06390
    Location:26392
    PBP1_iGluR_AMPA_GluR1; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
  3. NM_001258019.2NP_001244948.1  glutamate receptor 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001244948.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AB209094, AK295827, AL120214
    Consensus CDS
    CCDS58986.1
    UniProtKB/Swiss-Prot
    P42261
    UniProtKB/TrEMBL
    Q59GL5
    Related
    ENSP00000427920.1, ENST00000518142.5
    Conserved Domains (2) summary
    cd13729
    Location:326707
    PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cl10011
    Location:26312
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
  4. NM_001258020.2NP_001244949.1  glutamate receptor 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and has an alternate in-frame exon in place of another exon of the same size. The resulting isoform (4) is shorter at the N-terminus and has a different sequence (but same length) segment in the C-terminus compared to isoform 1.
    Source sequence(s)
    AB209094, AL120214, DC335107
    UniProtKB/TrEMBL
    Q59GL5
    Conserved Domains (4) summary
    cd13729
    Location:311692
    PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:443722
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:1277
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:1294
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
  5. NM_001258021.2NP_001244950.1  glutamate receptor 1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an alternate exon in place of the 5'-most exon of variant 1. The resulting isoform (5) has a longer and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AB209094, AK295184, AK295827, AK315934, AL120214
    Consensus CDS
    CCDS58987.1
    UniProtKB/Swiss-Prot
    P42261
    UniProtKB/TrEMBL
    Q59GL5
    Related
    ENSP00000428994.1, ENST00000518783.1
    Conserved Domains (4) summary
    cd06390
    Location:36399
    PBP1_iGluR_AMPA_GluR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
    cd13729
    Location:416797
    PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:548827
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:47382
    ANF_receptor; Receptor family ligand binding region
  6. NM_001258022.2NP_001244951.1  glutamate receptor 1 isoform 6

    See identical proteins and their annotated locations for NP_001244951.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has an alternate exon in place of the 5'-most exon of variant 1 and has an alternate in-frame exon in place of another exon of the same size. The resulting isoform (6) has a longer and distinct N-terminus and has a different sequence (but same length) segment in the C-terminus compared to isoform 1.
    Source sequence(s)
    AB209094, AK295184, AK315934, AL120214
    Consensus CDS
    CCDS58988.1
    UniProtKB/Swiss-Prot
    P42261
    UniProtKB/TrEMBL
    Q59GL5
    Related
    ENSP00000415569.2, ENST00000448073.8
    Conserved Domains (4) summary
    cd06390
    Location:36399
    PBP1_iGluR_AMPA_GluR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
    cd13729
    Location:416797
    PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:548827
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:47382
    ANF_receptor; Receptor family ligand binding region
  7. NM_001258023.1NP_001244952.1  glutamate receptor 1 isoform 7

    See identical proteins and their annotated locations for NP_001244952.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has an alternate exon in place of the 5'-most exon of variant 1. The resulting isoform (7) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AB209094, AK295039, AL120214
    Consensus CDS
    CCDS58989.1
    UniProtKB/Swiss-Prot
    P42261
    UniProtKB/TrEMBL
    Q59GL5
    Related
    ENSP00000427864.2, ENST00000521843.6
    Conserved Domains (2) summary
    cd13729
    Location:337718
    PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cl10011
    Location:1323
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
  8. NM_001364165.2NP_001351094.1  glutamate receptor 1 isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AC010613, AC091960, AC091962
    Conserved Domains (2) summary
    cd13729
    Location:350731
    PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cl10011
    Location:26336
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
  9. NM_001364166.2NP_001351095.1  glutamate receptor 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC010613, AC091960, AC091962
    Conserved Domains (2) summary
    cd06390
    Location:35398
    PBP1_iGluR_AMPA_GluR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
    cd13729
    Location:415796
    PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
  10. NM_001364167.2NP_001351096.1  glutamate receptor 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC010613, AC091960, AC091962
    Conserved Domains (2) summary
    cd13729
    Location:337718
    PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cl10011
    Location:1323
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

RNA

  1. NR_047578.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an alternate 5' exon and an alternate 3' exon compared to variant 1. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD) and is therefore thought to be non-protein coding.
    Source sequence(s)
    AB209094, AC091960, AK294011, AL120214
  2. NR_157093.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010613, AC091960, AC091962

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    153490670..153813873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009392.1XP_016864881.1  glutamate receptor 1 isoform X1

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