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ANK3 ankyrin 3 [ Homo sapiens (human) ]

Gene ID: 288, updated on 7-Dec-2018

Summary

Official Symbol
ANK3provided by HGNC
Official Full Name
ankyrin 3provided by HGNC
Primary source
HGNC:HGNC:494
See related
Ensembl:ENSG00000151150 MIM:600465
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRT37; ANKYRIN-G
Summary
Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
Expression
Broad expression in kidney (RPKM 10.0), brain (RPKM 9.0) and 23 other tissues See more
Orthologs

Genomic context

See ANK3 in Genome Data Viewer
Location:
10q21.2
Exon count:
52
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (60026298..60733526, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (61786056..62493284, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 6 Neighboring gene long intergenic non-protein coding RNA 1553 Neighboring gene Sharpr-MPRA regulatory region 4517 Neighboring gene uncharacterized LOC107987153 Neighboring gene uncharacterized LOC107984292 Neighboring gene ADP ribosylation factor like GTPase 4A pseudogene 1 Neighboring gene ANK3 divergent transcript Neighboring gene cyclin dependent kinase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Mental retardation, autosomal recessive 37
MedGen: C3809672 OMIM: 615493 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A genome-wide association meta-analysis of plasma Aβ peptides concentrations in the elderly.
NHGRI GWA Catalog
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
NHGRI GWA Catalog
Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort.
NHGRI GWA Catalog
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
NHGRI GWA Catalog
Genome-wide association study identifies five new schizophrenia loci.
NHGRI GWA Catalog
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
NHGRI GWA Catalog
Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder.
NHGRI GWA Catalog
Genome-wide association study reveals two new risk loci for bipolar disorder.
NHGRI GWA Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
NHGRI GWA Catalog
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
NHGRI GWA Catalog
Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of ankyrin 3 (ANK3, ankyrin G) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
    Asparagine N-linked glycosylation, organism-specific biosystemN-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 rev...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • COPI-mediated anterograde transport, organism-specific biosystem (from REACTOME)
    COPI-mediated anterograde transport, organism-specific biosystemThe ERGIC (ER-to-Golgi intermediate compartment, also known as vesicular-tubular clusters, VTCs) is a stable, biochemically distinct compartment located adjacent to ER exit sites (Ben-Tekaya et al, 2...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • ER to Golgi Anterograde Transport, organism-specific biosystem (from REACTOME)
    ER to Golgi Anterograde Transport, organism-specific biosystemSecretory cargo destined to be secreted or to arrive at the plasma membrane (PM) leaves the ER via distinct exit sites. This cargo is destined for the Golgi apparatus for further processing.
  • Interaction between L1 and Ankyrins, organism-specific biosystem (from REACTOME)
    Interaction between L1 and Ankyrins, organism-specific biosystemAnkyrins are a family of adaptor proteins that couple membrane proteins such as voltage gated Na+ channels and the Na+/K+ anion exchanger to the spectrin actin cytoskeleton. Ankyrins are encoded by t...
  • L1CAM interactions, organism-specific biosystem (from REACTOME)
    L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Transport to the Golgi and subsequent modification, organism-specific biosystem (from REACTOME)
    Transport to the Golgi and subsequent modification, organism-specific biosystemAt least two mechanisms of transport of proteins from the ER to the Golgi have been described. One is a general flow requiring no export signals (Wieland et al, 1987; Martinez-Menarguez et al, 1999)....
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45464

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cadherin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeletal protein binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
ion channel binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion channel binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding, bridging ISS
Inferred from Sequence or Structural Similarity
more info
 
spectrin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
structural constituent of cytoskeleton IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
Golgi to plasma membrane protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to magnesium ion ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeletal anchoring at plasma membrane TAS
Traceable Author Statement
more info
PubMed 
establishment of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
magnesium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
maintenance of protein location in plasma membrane IGI
Inferred from Genetic Interaction
more info
PubMed 
membrane assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of delayed rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
neuromuscular junction development ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cation channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell communication by electrical coupling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of homotypic cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of membrane depolarization during cardiac muscle cell action potential ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of membrane potential ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of protein targeting to membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of sodium ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of sodium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein localization to axon ISS
Inferred from Sequence or Structural Similarity
more info
 
protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to plasma membrane IGI
Inferred from Genetic Interaction
more info
PubMed 
protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of potassium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
T-tubule ISS
Inferred from Sequence or Structural Similarity
more info
 
Z disc ISS
Inferred from Sequence or Structural Similarity
more info
 
axon initial segment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axon initial segment IDA
Inferred from Direct Assay
more info
PubMed 
axon initial segment ISS
Inferred from Sequence or Structural Similarity
more info
 
basal plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
costamere TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
intercalated disc ISS
Inferred from Sequence or Structural Similarity
more info
 
lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
lysosome IEA
Inferred from Electronic Annotation
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuromuscular junction ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
node of Ranvier ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
sarcoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
spectrin-associated cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
ankyrin-3
Names
ankyrin 3, node of Ranvier (ankyrin G)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029917.1 RefSeqGene

    Range
    5001..712229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001149.3NP_001140.2  ankyrin-3 isoform 2

    See identical proteins and their annotated locations for NP_001140.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple differences in the 5' UTR and coding sequence compared to variant 1, resulting in an isoform (2) which is considerably shorter and different compared to isoform 1.
    Source sequence(s)
    AC023904, AK092527, AL136710, AL592430, AW451432
    Consensus CDS
    CCDS7259.1
    UniProtKB/Swiss-Prot
    Q12955
    UniProtKB/TrEMBL
    Q8NAK2
    Related
    ENSP00000347436.2, ENST00000355288.6
    Conserved Domains (2) summary
    smart00218
    Location:116220
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:609692
    Death_ank3; Death domain of Ankyrin-3
  2. NM_001204403.1NP_001191332.1  ankyrin-3 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at an alternate start codon, and lacks an alternate in-frame exon compared to variant 1. The encoded protein (isoform 3) has a distinct N-terminus and is considerably shorter than isoform 1.
    Source sequence(s)
    AC023904, AL359377, AW451432, BP245303, BX537917
    Consensus CDS
    CCDS55712.1
    UniProtKB/Swiss-Prot
    Q12955
    Related
    ENSP00000362933.2, ENST00000373827.6
    Conserved Domains (7) summary
    smart00218
    Location:9761080
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:14691552
    Death_ank3; Death domain of Ankyrin-3
    cd00204
    Location:62187
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:72158
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:625678
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:743797
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:690721
    ANK; ANK repeat [structural motif]
  3. NM_001204404.1NP_001191333.1  ankyrin-3 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at an alternate start codon, and lacks an alternate in-frame exon compared to variant 1. The encoded protein (isoform 4) has a distinct N-terminus and is considerably shorter than isoform 1.
    Source sequence(s)
    AC023904, AK295661, AL359377, AL391707, AL592430, AW451432
    Consensus CDS
    CCDS55711.1
    UniProtKB/Swiss-Prot
    Q12955
    Related
    ENSP00000425236.1, ENST00000503366.5
    Conserved Domains (7) summary
    smart00218
    Location:9831087
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:14761559
    Death_ank3; Death domain of Ankyrin-3
    cd00204
    Location:51176
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:61147
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:614667
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:732786
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:679710
    ANK; ANK repeat [structural motif]
  4. NM_001320874.1NP_001307803.1  ankyrin-3 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains one and lacks two alternate in-frame exons in its 3' coding region compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AC023904, AL359377, AL592430, AW451432, BP202757, BP310397, DB237893
    Conserved Domains (7) summary
    smart00218
    Location:9821086
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:14751558
    Death_ank3; Death domain of Ankyrin-3
    cd00204
    Location:68193
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:78164
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:631684
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:749803
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:696727
    ANK; ANK repeat [structural motif]
  5. NM_020987.5NP_066267.2  ankyrin-3 isoform 1

    See identical proteins and their annotated locations for NP_066267.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC023904, AL359377, AL592430, AW451432, BP202757, U13616
    Consensus CDS
    CCDS7258.1
    UniProtKB/Swiss-Prot
    Q12955
    Related
    ENSP00000280772.1, ENST00000280772.6
    Conserved Domains (7) summary
    smart00218
    Location:9821086
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:40884171
    Death_ank3; Death domain of Ankyrin-3
    cd00204
    Location:68193
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:78164
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:631684
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:749803
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:696727
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    60026298..60733526 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447958.1XP_024303726.1  ankyrin-3 isoform X12

    Conserved Domains (6) summary
    smart00218
    Location:9651069
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:40734156
    Death_ank3; Death domain of Ankyrin-3
    cd00204
    Location:51176
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:679710
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:746798
    Ank_4; Ankyrin repeats (many copies)
    cl25496
    Location:13761755
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  2. XM_017016114.1XP_016871603.1  ankyrin-3 isoform X6

  3. XM_024447957.1XP_024303725.1  ankyrin-3 isoform X11

    Conserved Domains (6) summary
    smart00218
    Location:9711075
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:40794162
    Death_ank3; Death domain of Ankyrin-3
    cd00204
    Location:68193
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:663694
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:567618
    Ank_4; Ankyrin repeats (many copies)
    cl25496
    Location:13821761
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  4. XM_024447960.1XP_024303728.1  ankyrin-3 isoform X14

    Conserved Domains (6) summary
    smart00218
    Location:9611065
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:40694152
    Death_ank3; Death domain of Ankyrin-3
    cd00204
    Location:68193
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:696727
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:763815
    Ank_4; Ankyrin repeats (many copies)
    cl25496
    Location:13721751
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  5. XM_017016134.1XP_016871623.1  ankyrin-3 isoform X42

  6. XM_017016127.1XP_016871616.1  ankyrin-3 isoform X32

  7. XM_017016141.1XP_016871630.1  ankyrin-3 isoform X46

  8. XM_017016126.1XP_016871615.1  ankyrin-3 isoform X31

  9. XM_024447961.1XP_024303729.1  ankyrin-3 isoform X15

    Conserved Domains (6) summary
    smart00218
    Location:9601064
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:40684151
    Death_ank3; Death domain of Ankyrin-3
    cd00204
    Location:68193
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:696727
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:763815
    Ank_4; Ankyrin repeats (many copies)
    cl25496
    Location:13711750
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  10. XM_024447959.1XP_024303727.1  ankyrin-3 isoform X13

    Conserved Domains (6) summary
    smart00218
    Location:9651069
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:40734156
    Death_ank3; Death domain of Ankyrin-3
    cd00204
    Location:68193
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:696727
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:763815
    Ank_4; Ankyrin repeats (many copies)
    cl25496
    Location:13761755
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  11. XM_024447955.1XP_024303723.1  ankyrin-3 isoform X8

    Conserved Domains (6) summary
    smart00218
    Location:9831087
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:40914174
    Death_ank3; Death domain of Ankyrin-3
    cd00204
    Location:68193
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:696727
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:763815
    Ank_4; Ankyrin repeats (many copies)
    cl25496
    Location:13941773
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  12. XM_017016131.1XP_016871620.1  ankyrin-3 isoform X40

  13. XM_017016132.1XP_016871621.1  ankyrin-3 isoform X41

  14. XM_017016130.1XP_016871619.1  ankyrin-3 isoform X39

  15. XM_017016122.1XP_016871611.1  ankyrin-3 isoform X26

  16. XM_024447956.1XP_024303724.1  ankyrin-3 isoform X9

    Conserved Domains (6) summary
    smart00218
    Location:9821086
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:40904173
    Death_ank3; Death domain of Ankyrin-3
    cd00204
    Location:68193
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:696727
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:763815
    Ank_4; Ankyrin repeats (many copies)
    cl25496
    Location:13931772
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  17. XM_024447954.1XP_024303722.1  ankyrin-3 isoform X7

    Conserved Domains (6) summary
    smart00218
    Location:9861090
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:40944177
    Death_ank3; Death domain of Ankyrin-3
    cd00204
    Location:68193
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:696727
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:763815
    Ank_4; Ankyrin repeats (many copies)
    cl25496
    Location:13971776
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  18. XM_017016125.1XP_016871614.1  ankyrin-3 isoform X30

  19. XM_024447953.1XP_024303721.1  ankyrin-3 isoform X5

    Conserved Domains (6) summary
    smart00218
    Location:9951099
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:41034186
    Death_ank3; Death domain of Ankyrin-3
    cd00204
    Location:68193
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:696727
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:763815
    Ank_4; Ankyrin repeats (many copies)
    cl25496
    Location:14061785
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  20. XM_005269715.3XP_005269772.1  ankyrin-3 isoform X38

    Conserved Domains (7) summary
    smart00218
    Location:10001104
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:14931576
    Death_ank3; Death domain of Ankyrin-3
    cd00204
    Location:68193
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:78164
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:631684
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:749803
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:696727
    ANK; ANK repeat [structural motif]
  21. XM_017016111.1XP_016871600.1  ankyrin-3 isoform X2

  22. XM_017016112.1XP_016871601.1  ankyrin-3 isoform X3

  23. XM_024447964.1XP_024303732.1  ankyrin-3 isoform X33

    Conserved Domains (5) summary
    smart00218
    Location:10041108
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:14851568
    Death_ank3; Death domain of Ankyrin-3
    cd00204
    Location:68193
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:696727
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:763815
    Ank_4; Ankyrin repeats (many copies)
  24. XM_017016138.1XP_016871627.1  ankyrin-3 isoform X45

  25. XM_017016137.1XP_016871626.1  ankyrin-3 isoform X44

  26. XM_017016129.1XP_016871618.1  ankyrin-3 isoform X36

  27. XM_017016128.1XP_016871617.1  ankyrin-3 isoform X35

  28. XM_017016124.1XP_016871613.1  ankyrin-3 isoform X29

  29. XM_017016121.1XP_016871610.1  ankyrin-3 isoform X22

  30. XM_024447962.1XP_024303730.1  ankyrin-3 isoform X18

    Conserved Domains (6) summary
    smart00218
    Location:10041108
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:36563739
    Death_ank3; Death domain of Ankyrin-3
    cd00204
    Location:68193
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:696727
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:763815
    Ank_4; Ankyrin repeats (many copies)
    cl25496
    Location:14151785
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  31. XM_017016113.1XP_016871602.1  ankyrin-3 isoform X4

  32. XM_024447965.1XP_024303733.1  ankyrin-3 isoform X37

    Conserved Domains (5) summary
    smart00218
    Location:10041108
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:14941577
    Death_ank3; Death domain of Ankyrin-3
    cd00204
    Location:68193
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:696727
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:763815
    Ank_4; Ankyrin repeats (many copies)
  33. XM_017016136.1XP_016871625.1  ankyrin-3 isoform X43

  34. XM_006717802.3XP_006717865.1  ankyrin-3 isoform X34

    Conserved Domains (7) summary
    smart00218
    Location:10041108
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:15061589
    Death_ank3; Death domain of Ankyrin-3
    cd00204
    Location:68193
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:78164
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:631684
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:749803
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:696727
    ANK; ANK repeat [structural motif]
  35. XM_017016123.1XP_016871612.1  ankyrin-3 isoform X28

  36. XM_011539709.2XP_011538011.1  ankyrin-3 isoform X27

    Conserved Domains (7) summary
    smart00218
    Location:10041108
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:23672450
    Death_ank3; Death domain of Ankyrin-3
    cd00204
    Location:68193
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:78164
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:631684
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:749803
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:696727
    ANK; ANK repeat [structural motif]
  37. XM_006717796.3XP_006717859.1  ankyrin-3 isoform X25

    Conserved Domains (7) summary
    smart00218
    Location:10041108
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:23672450
    Death_ank3; Death domain of Ankyrin-3
    cd00204
    Location:68193
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:78164
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:631684
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:749803
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:696727
    ANK; ANK repeat [structural motif]
  38. XM_011539708.2XP_011538010.1  ankyrin-3 isoform X24

    Conserved Domains (7) summary
    smart00218
    Location:10041108
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:23672450
    Death_ank3; Death domain of Ankyrin-3
    cd00204
    Location:68193
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:78164
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:631684
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:749803
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:696727
    ANK; ANK repeat [structural motif]
  39. XM_024447963.1XP_024303731.1  ankyrin-3 isoform X23

    Conserved Domains (6) summary
    smart00218
    Location:10041108
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:23672450
    Death_ank3; Death domain of Ankyrin-3
    cd00204
    Location:68193
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:696727
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:763815
    Ank_4; Ankyrin repeats (many copies)
    cl25496
    Location:14151794
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  40. XM_017016120.1XP_016871609.1  ankyrin-3 isoform X21

  41. XM_017016119.1XP_016871608.1  ankyrin-3 isoform X20

  42. XM_017016118.1XP_016871607.1  ankyrin-3 isoform X19

  43. XM_017016117.1XP_016871606.1  ankyrin-3 isoform X17

  44. XM_017016116.1XP_016871605.1  ankyrin-3 isoform X16

  45. XM_017016110.1XP_016871599.1  ankyrin-3 isoform X1

  46. XM_017016115.1XP_016871604.1  ankyrin-3 isoform X10

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