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KRT6C keratin 6C [ Homo sapiens (human) ]

Gene ID: 286887, updated on 25-May-2017
Official Symbol
KRT6Cprovided by HGNC
Official Full Name
keratin 6Cprovided by HGNC
Primary source
HGNC:HGNC:20406
See related
Ensembl:ENSG00000170465 MIM:612315; Vega:OTTHUMG00000169596
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K6E; KRT6E; PPKNEFD
Summary
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq, Jul 2009]
Orthologs
Location:
12q13.13
Exon count:
9
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 12 NC_000012.12 (52468516..52473785, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (52862300..52867569, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene keratin 75 Neighboring gene keratin 6B Neighboring gene uncharacterized LOC107984511 Neighboring gene keratin 6A Neighboring gene keratin 5

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Keratinization, organism-specific biosystem (from REACTOME)
    Keratinization, organism-specific biosystemKeratins are the major structural protein of vertebrate epidermis, constituting up to 85% of a fully differentiated keratinocyte (Fuchs 1995). Keratins belong to a superfamily of intermediate filamen...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC102925, MGC163455, MGC163457

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cornification TAS
Traceable Author Statement
more info
 
intermediate filament cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
keratinization TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
intermediate filament NAS
Non-traceable Author Statement
more info
PubMed 
keratin filament IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
keratin, type II cytoskeletal 6C
Names
CK-6C
CK-6E
K6C
cytokeratin-6C
cytokeratin-6E
keratin 6C, type II
keratin 6E
keratin K6h
type-II keratin Kb12

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012416.1 RefSeqGene

    Range
    5001..10270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_173086.4NP_775109.2  keratin, type II cytoskeletal 6C

    See identical proteins and their annotated locations for NP_775109.2

    Status: REVIEWED

    Source sequence(s)
    AC055736, BC110639
    Consensus CDS
    CCDS8829.1
    UniProtKB/Swiss-Prot
    P48668
    Related
    ENSP00000252250.6, OTTHUMP00000241633, ENST00000252250.6, OTTHUMT00000404976
    Conserved Domains (2) summary
    pfam00038
    Location:162475
    Filament; Intermediate filament protein
    pfam16208
    Location:17159
    Keratin_2_head; Keratin type II head

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p7 Primary Assembly

    Range
    52468516..52473785 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    52829152..52834426 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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