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KRT6C keratin 6C [ Homo sapiens (human) ]

Gene ID: 286887, updated on 17-Sep-2024

Summary

Official Symbol
KRT6Cprovided by HGNC
Official Full Name
keratin 6Cprovided by HGNC
Primary source
HGNC:HGNC:20406
See related
Ensembl:ENSG00000170465 MIM:612315; AllianceGenome:HGNC:20406
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K6E; KRT6E; PPKNEFD
Summary
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq, Jul 2009]
Expression
Restricted expression toward esophagus (RPKM 948.5) See more
Orthologs
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Genomic context

See KRT6C in Genome Data Viewer
Location:
12q13.13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (52468516..52473805, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (52433115..52438404, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (52862300..52867589, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene keratin 75 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52831010-52831512 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:52835896-52837095 Neighboring gene keratin 6B Neighboring gene keratin 6A Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:52909857-52911056 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:52912066-52913265 Neighboring gene keratin 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC102925, MGC163455, MGC163457

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of skin epidermis IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in intermediate filament cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in keratinization IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in intermediate filament NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in keratin filament IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
keratin, type II cytoskeletal 6C
Names
CK-6C
CK-6E
K6C
cytokeratin-6C
cytokeratin-6E
keratin 6C, type II
keratin 6E
keratin K6h
type-II keratin Kb12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012416.1 RefSeqGene

    Range
    4981..10270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_173086.5NP_775109.2  keratin, type II cytoskeletal 6C

    See identical proteins and their annotated locations for NP_775109.2

    Status: REVIEWED

    Source sequence(s)
    AC055736, BC110639
    Consensus CDS
    CCDS8829.1
    UniProtKB/Swiss-Prot
    A1L4L5, P48666, P48668, Q2TAZ9, Q7RTN9
    UniProtKB/TrEMBL
    B2R853
    Related
    ENSP00000252250.6, ENST00000252250.7
    Conserved Domains (2) summary
    pfam00038
    Location:162475
    Filament; Intermediate filament protein
    pfam16208
    Location:17159
    Keratin_2_head; Keratin type II head

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    52468516..52473805 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    52433115..52438404 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)