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GPR34 G protein-coupled receptor 34 [ Homo sapiens (human) ]

Gene ID: 2857, updated on 23-Nov-2021

Summary

Official Symbol
GPR34provided by HGNC
Official Full Name
G protein-coupled receptor 34provided by HGNC
Primary source
HGNC:HGNC:4490
See related
Ensembl:ENSG00000171659 MIM:300241
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LYPSR1
Summary
G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM, Apr 2006]
Expression
Broad expression in placenta (RPKM 8.9), fat (RPKM 7.8) and 21 other tissues See more
Orthologs
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Genomic context

See GPR34 in Genome Data Viewer
Location:
Xp11.4
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (41686397..41697275)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (41548226..41556528)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin dependent serine protein kinase Neighboring gene YWHAZ pseudogene 10 Neighboring gene RNA, 7SL, cytoplasmic 144, pseudogene Neighboring gene G protein-coupled receptor 82 Neighboring gene ribosomal protein S15a pseudogene 39

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of G protein-coupled receptor 34 (GPR34) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled purinergic nucleotide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
probable G-protein coupled receptor 34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001097579.2NP_001091048.1  probable G-protein coupled receptor 34

    See identical proteins and their annotated locations for NP_001091048.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longer transcript. Both variants 1 and 4 encode the same protein.
    Source sequence(s)
    AK027780, AL627402, BM798913, N40174
    Consensus CDS
    CCDS14258.1
    UniProtKB/Swiss-Prot
    Q9UPC5
    UniProtKB/TrEMBL
    Q5VT14
    Related
    ENSP00000367384.4, ENST00000378142.9
    Conserved Domains (1) summary
    cd15148
    Location:55338
    7tmA_GPR34-like; putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_005300.4NP_005291.1  probable G-protein coupled receptor 34

    See identical proteins and their annotated locations for NP_005291.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 4. Both variants 1 and 4 encode the same protein.
    Source sequence(s)
    AK027780, AW292321, BC020678, H03136
    Consensus CDS
    CCDS14258.1
    UniProtKB/Swiss-Prot
    Q9UPC5
    UniProtKB/TrEMBL
    Q5VT14
    Related
    ENSP00000367378.5, ENST00000378138.5
    Conserved Domains (1) summary
    cd15148
    Location:55338
    7tmA_GPR34-like; putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    41686397..41697275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005272597.4XP_005272654.1  probable G-protein coupled receptor 34 isoform X1

    See identical proteins and their annotated locations for XP_005272654.1

    UniProtKB/Swiss-Prot
    Q9UPC5
    UniProtKB/TrEMBL
    Q5VT14
    Conserved Domains (1) summary
    cd15148
    Location:55338
    7tmA_GPR34-like; putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033513.2: Suppressed sequence

    Description
    NM_001033513.2: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
  2. NM_001033514.1: Suppressed sequence

    Description
    NM_001033514.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
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