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EPHA10 EPH receptor A10 [ Homo sapiens (human) ]

Gene ID: 284656, updated on 16-Aug-2021

Summary

Official Symbol
EPHA10provided by HGNC
Official Full Name
EPH receptor A10provided by HGNC
Primary source
HGNC:HGNC:19987
See related
Ensembl:ENSG00000183317 MIM:611123
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005 [PubMed 15777695]). See MIM 179610 for additional background on Eph receptors and ephrins.[supplied by OMIM, Mar 2008]
Expression
Biased expression in testis (RPKM 7.0), colon (RPKM 2.9) and 7 other tissues See more
Orthologs
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Genomic context

See EPHA10 in Genome Data Viewer
Location:
1p34.3
Exon count:
23
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (37713888..37765120, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (38181648..38230792, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene chromosome 1 open reading frame 109 Neighboring gene cell division cycle associated 8 Neighboring gene uncharacterized LOC105378650 Neighboring gene actinin alpha 4 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
GeneReviews: Not available
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16103, FLJ33655, MGC43817

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane-ephrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in biological_process ND
No biological Data available
more info
 
involved_in ephrin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ephrin type-A receptor 10
Names
EphA10s protein
NP_001092909.1
NP_775912.2
XP_016856569.1
XP_016856570.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099439.2NP_001092909.1  ephrin type-A receptor 10 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001092909.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longer transcript and encodes the longer isoform (3).
    Source sequence(s)
    AC104336, AJ872185, BC039363, BC041360
    Consensus CDS
    CCDS41305.1
    UniProtKB/Swiss-Prot
    Q5JZY3
    UniProtKB/TrEMBL
    Q4G0R4
    Related
    ENSP00000362139.4, ENST00000373048.9
    Conserved Domains (8) summary
    cd05064
    Location:639904
    PTKc_EphR_A10; Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A10
    smart00454
    Location:932997
    SAM; Sterile alpha motif
    cd00063
    Location:451531
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:339431
    fn3; Fibronectin type III domain
    pfam07714
    Location:645900
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:573640
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:35210
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
    cl15755
    Location:929998
    SAM_superfamily; SAM (Sterile alpha motif )
  2. NM_173641.3NP_775912.2  ephrin type-A receptor 10 isoform 2 precursor

    See identical proteins and their annotated locations for NP_775912.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains only the first three exons and some of the third intron compared to variant 3. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 3.
    Source sequence(s)
    AJ781169, AK090974, BC067734
    Consensus CDS
    CCDS425.1
    UniProtKB/Swiss-Prot
    Q5JZY3
    UniProtKB/TrEMBL
    Q8N289
    Related
    ENSP00000316395.6, ENST00000319637.6
    Conserved Domains (1) summary
    cl02704
    Location:35210
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    37713888..37765120 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001080.1XP_016856569.1  ephrin type-A receptor 10 isoform X1

    Related
    ENST00000446149.6
  2. XM_017001081.1XP_016856570.1  ephrin type-A receptor 10 isoform X2

RNA

  1. XR_946610.1 RNA Sequence

    Related
    ENST00000437645.5
  2. XR_001737124.1 RNA Sequence

  3. XR_946613.2 RNA Sequence

  4. XR_001737123.1 RNA Sequence

  5. XR_001737125.2 RNA Sequence

    Related
    ENST00000534097.5
  6. XR_001737127.1 RNA Sequence

  7. XR_001737126.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001004338.2: Suppressed sequence

    Description
    NM_001004338.2: This RefSeq was permanently suppressed because the encoded protein is partial, and it is a nonsense-mediated mRNA decay (NMD) candidate.
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