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Epha10 Eph receptor A10 [ Mus musculus (house mouse) ]

Gene ID: 230735, updated on 2-Oct-2018

Summary

Official Symbol
Epha10provided by MGI
Official Full Name
Eph receptor A10provided by MGI
Primary source
MGI:MGI:3586824
See related
Ensembl:ENSMUSG00000028876 Vega:OTTMUSG00000009202
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A330090H18
Expression
Biased expression in cortex adult (RPKM 7.2), frontal lobe adult (RPKM 6.4) and 7 other tissues See more
Orthologs

Genomic context

See Epha10 in Genome Data Viewer
Location:
4; 4 D2.2
Exon count:
20
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (124881785..124917800)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (124559029..124563752)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene metal response element binding transcription factor 1 Neighboring gene RIKEN cDNA 1110065P20 gene Neighboring gene yrdC domain containing (E.coli) Neighboring gene mannosidase, endo-alpha-like Neighboring gene RIKEN cDNA 1700125G02 gene Neighboring gene cell division cycle associated 8 Neighboring gene RIKEN cDNA 9930104L06 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane-ephrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane-ephrin receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ephrin type-A receptor 10
NP_001243361.1
NP_808339.2
XP_006503090.1
XP_006503091.1
XP_017175641.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256432.2NP_001243361.1  ephrin type-A receptor 10 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL606933
    Conserved Domains (7) summary
    cd09549
    Location:928997
    SAM_EPH-A10; SAM domain of EPH-A10 subfamily of tyrosine kinase receptors
    smart00454
    Location:931996
    SAM; Sterile alpha motif
    cd00063
    Location:451551
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07714
    Location:644899
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:573639
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:35210
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
    cl21453
    Location:638902
    PKc_like; Protein Kinases, catalytic domain
  2. NM_177671.6NP_808339.2  ephrin type-A receptor 10 isoform 2 precursor

    See identical proteins and their annotated locations for NP_808339.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK143168
    Consensus CDS
    CCDS18630.1
    UniProtKB/Swiss-Prot
    Q8BYG9
    Related
    ENSMUSP00000050810.5, OTTMUSP00000009548, ENSMUST00000059343.6
    Conserved Domains (1) summary
    cl02704
    Location:35210
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

    Range
    124881785..124917800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503027.1XP_006503090.1  ephrin type-A receptor 10 isoform X2

    Conserved Domains (4) summary
    cd00063
    Location:465551
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:339431
    fn3; Fibronectin type III domain
    pfam14575
    Location:573639
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:35210
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
  2. XM_006503028.3XP_006503091.1  ephrin type-A receptor 10 isoform X3

    Conserved Domains (3) summary
    cd00063
    Location:465551
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:339431
    fn3; Fibronectin type III domain
    cl02704
    Location:35210
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
  3. XM_017320152.1XP_017175641.1  ephrin type-A receptor 10 isoform X1

    Related
    ENSMUSP00000118801.1, OTTMUSP00000009549, ENSMUST00000149146.1, OTTMUST00000020822

RNA

  1. XR_376312.1 RNA Sequence

  2. XR_001784128.1 RNA Sequence

  3. XR_001784129.1 RNA Sequence

  4. XR_867853.1 RNA Sequence

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