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SLC26A11 solute carrier family 26 member 11 [ Homo sapiens (human) ]

Gene ID: 284129, updated on 7-Jun-2020

Summary

Official Symbol
SLC26A11provided by HGNC
Official Full Name
solute carrier family 26 member 11provided by HGNC
Primary source
HGNC:HGNC:14471
See related
Ensembl:ENSG00000181045 MIM:610117
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the solute linked carrier 26 family of anion exchangers. Members of this family of proteins are essential for numerous cellular functions including homeostasis and intracellular electrolyte balance. The encoded protein is a sodium independent sulfate transporter that is sensitive to the anion exchanger inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in adrenal (RPKM 8.3), spleen (RPKM 6.4) and 25 other tissues See more
Orthologs

Genomic context

See SLC26A11 in Genome Data Viewer
Location:
17q25.3
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (80220287..80253502)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (78194200..78227308)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4A3 Neighboring gene caspase recruitment domain family member 14 Neighboring gene N-sulfoglucosamine sulfohydrolase Neighboring gene SLC26A11-RNF213 intergenic CAGE-defined mid-level expression enhancer Neighboring gene CRISPRi-validated cis-regulatory element chr17.5742

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC46523

Gene Ontology Provided by GOA

Function Evidence Code Pubs
anion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
anion:anion antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
secondary active sulfate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sulfate transmembrane transporter activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
ion transport TAS
Traceable Author Statement
more info
 
sulfate transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
sulfate transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sodium-independent sulfate anion transporter
Names
solute carrier family 26 (anion exchanger), member 11

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166347.2NP_001159819.1  sodium-independent sulfate anion transporter

    See identical proteins and their annotated locations for NP_001159819.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AI963799, AK075248, AK315132, BC035900, DA290933
    Consensus CDS
    CCDS11771.2
    UniProtKB/Swiss-Prot
    Q86WA9
    Related
    ENSP00000355384.3, ENST00000361193.8
    Conserved Domains (3) summary
    cd07042
    Location:470564
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:35559
    sulP; high affinity sulphate transporter 1
    cl06211
    Location:221334
    DUF1341; Protein of unknown function (DUF1341)
  2. NM_001166348.2NP_001159820.1  sodium-independent sulfate anion transporter

    See identical proteins and their annotated locations for NP_001159820.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AI963799, AK075248, AL833468, DA290933
    Consensus CDS
    CCDS11771.2
    UniProtKB/Swiss-Prot
    Q86WA9
    Related
    ENSP00000440724.2, ENST00000546047.6
    Conserved Domains (3) summary
    cd07042
    Location:470564
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:35559
    sulP; high affinity sulphate transporter 1
    cl06211
    Location:221334
    DUF1341; Protein of unknown function (DUF1341)
  3. NM_001166349.2NP_001159821.1  sodium-independent sulfate anion transporter

    See identical proteins and their annotated locations for NP_001159821.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AF331524, AF345195, AI963799, AK075248, DA290933
    Consensus CDS
    CCDS11771.2
    UniProtKB/Swiss-Prot
    Q86WA9
    Related
    ENSP00000459470.1, ENST00000572725.5
    Conserved Domains (3) summary
    cd07042
    Location:470564
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:35559
    sulP; high affinity sulphate transporter 1
    cl06211
    Location:221334
    DUF1341; Protein of unknown function (DUF1341)
  4. NM_173626.4NP_775897.3  sodium-independent sulfate anion transporter

    See identical proteins and their annotated locations for NP_775897.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC123764, AI963799, AK075248, DA290933
    Consensus CDS
    CCDS11771.2
    UniProtKB/Swiss-Prot
    Q86WA9
    Related
    ENSP00000403998.3, ENST00000411502.7
    Conserved Domains (3) summary
    cd07042
    Location:470564
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:35559
    sulP; high affinity sulphate transporter 1
    cl06211
    Location:221334
    DUF1341; Protein of unknown function (DUF1341)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    80220287..80253502
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024505.1XP_016879994.1  sodium-independent sulfate anion transporter isoform X1

  2. XM_017024506.1XP_016879995.1  sodium-independent sulfate anion transporter isoform X2

  3. XM_006721833.2XP_006721896.1  sodium-independent sulfate anion transporter isoform X3

    Conserved Domains (3) summary
    cd07042
    Location:494588
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:35583
    sulP; high affinity sulphate transporter 1
    cl06211
    Location:245358
    DUF1341; Protein of unknown function (DUF1341)
  4. XM_011524654.1XP_011522956.1  sodium-independent sulfate anion transporter isoform X5

    See identical proteins and their annotated locations for XP_011522956.1

    Conserved Domains (1) summary
    COG0659
    Location:84411
    SUL1; Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism]
  5. XM_017024507.1XP_016879996.1  sodium-independent sulfate anion transporter isoform X3

    Conserved Domains (3) summary
    cd07042
    Location:494588
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:35583
    sulP; high affinity sulphate transporter 1
    cl06211
    Location:245358
    DUF1341; Protein of unknown function (DUF1341)
  6. XM_024450710.1XP_024306478.1  sodium-independent sulfate anion transporter isoform X4

    Conserved Domains (1) summary
    COG0659
    Location:108435
    SUL1; Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism]
  7. XM_024450711.1XP_024306479.1  sodium-independent sulfate anion transporter isoform X5

    Conserved Domains (1) summary
    COG0659
    Location:84411
    SUL1; Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism]

RNA

  1. XR_001752499.1 RNA Sequence

  2. XR_001752498.1 RNA Sequence

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