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GPLD1 glycosylphosphatidylinositol specific phospholipase D1 [ Homo sapiens (human) ]

Gene ID: 2822, updated on 22-Aug-2021

Summary

Official Symbol
GPLD1provided by HGNC
Official Full Name
glycosylphosphatidylinositol specific phospholipase D1provided by HGNC
Primary source
HGNC:HGNC:4459
See related
Ensembl:ENSG00000112293 MIM:602515
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLD; GPIPLD; PIGPLD; GPIPLDM; PIGPLD1
Summary
Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver (RPKM 12.6), skin (RPKM 4.0) and 8 other tissues See more
Orthologs
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Genomic context

See GPLD1 in Genome Data Viewer
Location:
6p22.3
Exon count:
26
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (24423969..24495232, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (24426060..24489806, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene doublecortin domain containing 2 Neighboring gene RNA, U6 small nuclear 391, pseudogene Neighboring gene kidney associated antigen 1 Neighboring gene magnesium transporter MRS2 Neighboring gene aldehyde dehydrogenase 5 family member A1 Neighboring gene KIAA0319 Neighboring gene keratin 8 pseudogene 43 Neighboring gene Sharpr-MPRA regulatory region 5933 Neighboring gene tyrosyl-DNA phosphodiesterase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
GeneReviews: Not available
Genome-wide association study of hematological and biochemical traits in a Japanese population.
GeneReviews: Not available
Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of glycosylphosphatidylinositol specific phospholipase D1 (GPLD1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC22590

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in C-terminal protein lipidation TAS
Traceable Author Statement
more info
 
involved_in GPI anchor release IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in GPI anchor release IDA
Inferred from Direct Assay
more info
PubMed 
involved_in GPI anchor release IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to cholesterol IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to pH IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to triglyceride IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chondrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in complement receptor mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hematopoietic stem cell migration TAS
Traceable Author Statement
more info
PubMed 
involved_in hematopoietic stem cell migration to bone marrow TAS
Traceable Author Statement
more info
PubMed 
involved_in insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of triglyceride catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ossification ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phosphatidylcholine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phosphatidylcholine metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of alkaline phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of glucose metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of high-density lipoprotein particle clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of membrane protein ectodomain proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of triglyceride biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to glucose IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transepithelial transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular exosome HDA PubMed 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosomal membrane HDA PubMed 

General protein information

Preferred Names
phosphatidylinositol-glycan-specific phospholipase D
Names
GPI-PLD
GPI-specific phospholipase D
PI-G PLD
glycoprotein phospholipase D
NP_001494.2
XP_016866242.1
XP_024302171.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029888.2 RefSeqGene

    Range
    5045..68791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001503.4NP_001494.2  phosphatidylinositol-glycan-specific phospholipase D precursor

    See identical proteins and their annotated locations for NP_001494.2

    Status: REVIEWED

    Source sequence(s)
    AJ308108, AL031230, AL359713, AY007546, BU587813, L11702
    Consensus CDS
    CCDS4553.1
    UniProtKB/Swiss-Prot
    P80108
    Related
    ENSP00000230036.1, ENST00000230036.2
    Conserved Domains (3) summary
    smart00191
    Location:446499
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam00882
    Location:28211
    Zn_dep_PLPC; Zinc dependent phospholipase C
    pfam01839
    Location:514541
    FG-GAP; FG-GAP repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    24423969..24495232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010753.2XP_016866242.1  phosphatidylinositol-glycan-specific phospholipase D isoform X1

  2. XM_024446403.1XP_024302171.1  phosphatidylinositol-glycan-specific phospholipase D isoform X2

    Conserved Domains (2) summary
    smart00191
    Location:283336
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam01839
    Location:351378
    FG-GAP; FG-GAP repeat

RNA

  1. XR_002956277.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177483.1: Suppressed sequence

    Description
    NM_177483.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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