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Gpld1 glycosylphosphatidylinositol specific phospholipase D1 [ Mus musculus (house mouse) ]

Gene ID: 14756, updated on 8-May-2024

Summary

Official Symbol
Gpld1provided by MGI
Official Full Name
glycosylphosphatidylinositol specific phospholipase D1provided by MGI
Primary source
MGI:MGI:106604
See related
Ensembl:ENSMUSG00000021340 AllianceGenome:MGI:106604
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6330541J12Rik
Summary
Enables glycosylphosphatidylinositol phospholipase D activity and sodium channel regulator activity. Involved in several processes, including positive regulation of high-density lipoprotein particle clearance; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and regulation of triglyceride metabolic process. Acts upstream of or within GPI anchor release; chondrocyte differentiation; and ossification. Located in several cellular components, including extracellular matrix; extracellular space; and intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; central nervous system; ear; genitourinary system; and skeleton. Orthologous to human GPLD1 (glycosylphosphatidylinositol specific phospholipase D1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 33.5), liver E18 (RPKM 30.2) and 24 other tissues See more
Orthologs
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Genomic context

Location:
13 A3.1; 13 10.79 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (25127135..25175919)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (24937785..24991936)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4932702P03 gene Neighboring gene aldhehyde dehydrogenase family 5, subfamily A1 Neighboring gene cDNA RIKEN 9330162012 gene Neighboring gene STARR-seq mESC enhancer starr_33991 Neighboring gene predicted gene, 34019 Neighboring gene microRNA 12184 Neighboring gene MRS2 magnesium transporter Neighboring gene predicted gene, 52042 Neighboring gene STARR-positive B cell enhancer mm9_chr13:25142251-25142552 Neighboring gene STARR-seq mESC enhancer starr_33992 Neighboring gene doublecortin domain containing 2a Neighboring gene STARR-seq mESC enhancer starr_33993

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glycosylphosphatidylinositol phospholipase D activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glycosylphosphatidylinositol phospholipase D activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glycosylphosphatidylinositol phospholipase D activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase D activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipase D activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sodium channel regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in GPI anchor release IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within GPI anchor release IDA
Inferred from Direct Assay
more info
PubMed 
involved_in GPI anchor release IDA
Inferred from Direct Assay
more info
PubMed 
involved_in GPI anchor release IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in GPI anchor release ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cholesterol ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to inorganic substance ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to iron(II) ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to pH ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to triglyceride ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in chondrocyte differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in complement receptor mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of triglyceride catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ossification IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glucose metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of high-density lipoprotein particle clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of membrane protein ectodomain proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of triglyceride biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in response to glucose ISO
Inferred from Sequence Orthology
more info
 
involved_in transepithelial transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of high-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phosphatidylinositol-glycan-specific phospholipase D
Names
GPI-PLD
GPI-specific phospholipase D
PI-G PLD
glycoprotein phospholipase D
glycosyl-phosphatidylinositol-specific phospholipase D
NP_032182.2
XP_011242584.1
XP_030103017.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008156.2NP_032182.2  phosphatidylinositol-glycan-specific phospholipase D precursor

    See identical proteins and their annotated locations for NP_032182.2

    Status: VALIDATED

    Source sequence(s)
    AL645533, AY081194, BY236833
    Consensus CDS
    CCDS26384.1
    UniProtKB/TrEMBL
    Q8R432, Q8VCU2, Q9DBH3
    Related
    ENSMUSP00000021773.6, ENSMUST00000021773.13
    Conserved Domains (3) summary
    smart00191
    Location:446502
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam01839
    Location:514547
    FG-GAP; FG-GAP repeat
    pfam00882
    Location:28219
    Zn_dep_PLPC; Zinc dependent phospholipase C

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    25127135..25175919
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247157.2XP_030103017.1  phosphatidylinositol-glycan-specific phospholipase D isoform X1

    UniProtKB/TrEMBL
    Q8R432, Q9DBH3
    Conserved Domains (2) summary
    smart00191
    Location:321377
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam01839
    Location:389422
    FG-GAP; FG-GAP repeat
  2. XM_011244282.4XP_011242584.1  phosphatidylinositol-glycan-specific phospholipase D isoform X2

    Conserved Domains (2) summary
    smart00191
    Location:229285
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam01839
    Location:297330
    FG-GAP; FG-GAP repeat