GAP43 growth associated protein 43 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: GAP43provided by VGNC
Official Full Name: growth associated protein 43provided by VGNC
Primary source: VGNC:VGNC:29247
See related: BGD:BT25520; Ensembl:ENSBTAG00000006451
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	1	NC_037328.1 (60306675..60407777)

Chromosome 1 - NC_037328.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Both the synthetic N-terminal peptide GAP-43(1-40) and the brain-derived fragment GAP-43-3 preserved the ability to oligomerize under the action of acidic phospholipids and SDS.
Title: Oligomeric structure of brain abundant proteins GAP-43 and BASP1.
These results indicated the interaction of GAP-43 and Galpha(o) could accelerate conversion of depalmitoylated Galpha(o) but not palmitoylated Galpha(o) from oligomers to monomers, so as to increase the GTPgammaS binding activity of Galpha(o).
Title: Palmitoylation modification of Galpha(o) depresses its susceptibility to GAP-43 activation.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

GAP43-3UUTF (e-PCR)
- UniSTS:43266

GDB:181207 (e-PCR)
- UniSTS:155175

G10622 (e-PCR)
- UniSTS:78906

GAP43 (e-PCR)
- UniSTS:479844

BM1312 (e-PCR), detects polymorphism
- UniSTS:30885

GAP43 (e-PCR)
- UniSTS:497894

GDB:305514 (e-PCR)
- UniSTS:156413

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calmodulin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables lysophosphatidic acid binding	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphatidylinositol phosphate binding	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphatidylserine binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in axon choice point recognition	IEA Inferred from Electronic Annotation more info	PubMed
involved_in axon regeneration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of growth	IEA Inferred from Electronic Annotation more info	PubMed
involved_in tissue regeneration	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: neuromodulin

Names: axonal membrane protein GAP-43; calmodulin-binding protein P-57

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.