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Gap43 growth associated protein 43 [ Mus musculus (house mouse) ]

Gene ID: 14432, updated on 6-Oct-2024

Summary

Official Symbol
Gap43provided by MGI
Official Full Name
growth associated protein 43provided by MGI
Primary source
MGI:MGI:95639
See related
Ensembl:ENSMUSG00000047261 AllianceGenome:MGI:95639
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B-50; Basp2; GAP-43
Summary
Predicted to enable calmodulin binding activity and phospholipid binding activity. Acts upstream of or within axon choice point recognition; cell fate commitment; and glial cell differentiation. Located in several cellular components, including axon; plasma membrane; and postsynaptic density. Is expressed in several structures, including alimentary system; future brain; genitourinary system; nervous system; and sensory organ. Orthologous to human GAP43 (growth associated protein 43). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 514.6), CNS E14 (RPKM 264.7) and 5 other tissues See more
Orthologs
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Genomic context

See Gap43 in Genome Data Viewer
Location:
16 B4; 16 28.37 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (42068915..42161014, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (42248552..42340651, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene limbic system-associated membrane protein Neighboring gene STARR-seq mESC enhancer starr_40858 Neighboring gene STARR-seq mESC enhancer starr_40859 Neighboring gene predicted gene, 52229 Neighboring gene STARR-seq mESC enhancer starr_40861 Neighboring gene STARR-seq mESC enhancer starr_40862 Neighboring gene 60S ribosomal protein L34 pseudogene Neighboring gene microRNA 6540 Neighboring gene STARR-seq mESC enhancer starr_40865 Neighboring gene RIKEN cDNA 4932412D23 gene Neighboring gene STARR-seq mESC enhancer starr_40870 Neighboring gene STARR-positive B cell enhancer mm9_chr16:42836127-42836428 Neighboring gene STARR-seq mESC enhancer starr_40871 Neighboring gene STARR-positive B cell enhancer ABC_E52 Neighboring gene predicted gene, 29960

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables lysophosphatidic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables lysophosphatidic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables lysophosphatidic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol phosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol phosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylserine binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within astrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axon choice point recognition IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within axon choice point recognition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axon regeneration IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within radial glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of filopodium assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of growth IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of postsynaptic specialization assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of postsynaptic specialization assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in response to auditory stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in tissue regeneration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tissue regeneration IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in filopodium membrane IEA
Inferred from Electronic Annotation
more info
 
located_in filopodium membrane ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neuromodulin
Names
axonal membrane protein GAP-43
brain abundant, membrane attached signal protein 2
calmodulin-binding protein P-57
growth accentuating protein 43

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008083.2NP_032109.1  neuromodulin

    See identical proteins and their annotated locations for NP_032109.1

    Status: PROVISIONAL

    Source sequence(s)
    BC028288
    Consensus CDS
    CCDS28177.1
    UniProtKB/Swiss-Prot
    P06837
    Related
    ENSMUSP00000099881.5, ENSMUST00000102817.5
    Conserved Domains (2) summary
    smart00015
    Location:3052
    IQ; Calmodulin-binding motif
    pfam06614
    Location:73227
    Neuromodulin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    42068915..42161014 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)