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GAP43 growth associated protein 43 [ Homo sapiens (human) ]

Gene ID: 2596, updated on 8-Jul-2018
Official Symbol
GAP43provided by HGNC
Official Full Name
growth associated protein 43provided by HGNC
Primary source
HGNC:HGNC:4140
See related
Ensembl:ENSG00000172020 MIM:162060; Vega:OTTHUMG00000133758
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B-50; PP46
Summary
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 55.1) and appendix (RPKM 1.7) See more
Orthologs
See GAP43 in Genome Data Viewer
Location:
3q13.31
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (115623304..115721487)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (115342151..115440334)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101926886 Neighboring gene eukaryotic translation initiation factor 4E family member 2 pseudogene 2 Neighboring gene uncharacterized LOC105374051 Neighboring gene 3q13.2-q13.31 distal HERV-H recombination region Neighboring gene RNA, 7SL, cytoplasmic 815, pseudogene Neighboring gene limbic system associated membrane protein

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of growth associated protein 43 (GAP43) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Glial Cell Differentiation, organism-specific biosystem (from WikiPathways)
    Glial Cell Differentiation, organism-specific biosystem
    Glial Cell Differentiation
  • L1CAM interactions, organism-specific biosystem (from REACTOME)
    L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
  • N-cadherin signaling events, organism-specific biosystem (from Pathway Interaction Database)
    N-cadherin signaling events, organism-specific biosystem
    N-cadherin signaling events
  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
lysophosphatidic acid binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol phosphate binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylserine binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
axon choice point recognition IEA
Inferred from Electronic Annotation
more info
 
cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
glial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
protein kinase C-activating G-protein coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
regulation of filopodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
response to wounding TAS
Traceable Author Statement
more info
PubMed 
tissue regeneration IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
filopodium membrane IDA
Inferred from Direct Assay
more info
PubMed 
growth cone membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Preferred Names
neuromodulin
Names
axonal membrane protein GAP-43
calmodulin-binding protein P-57
nerve growth-related peptide GAP43
neural phosphoprotein B-50
neuron growth-associated protein 43
protein F1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130064.1NP_001123536.1  neuromodulin isoform 1

    See identical proteins and their annotated locations for NP_001123536.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK289699, BX648458, DA701390
    Consensus CDS
    CCDS46890.1
    UniProtKB/Swiss-Prot
    P17677
    Related
    ENSP00000377372.3, OTTHUMP00000165226, ENST00000393780.3, OTTHUMT00000258217
    Conserved Domains (3) summary
    smart00015
    Location:6688
    IQ; Calmodulin-binding motif
    pfam06614
    Location:107274
    Neuromodulin; Neuromodulin
    pfam10310
    Location:89203
    DUF2413; Protein of unknown function (DUF2413)
  2. NM_002045.3NP_002036.1  neuromodulin isoform 2

    See identical proteins and their annotated locations for NP_002036.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal exon and has an upstream AUG start codon, as compared to variant 1. The resulting isoform 2 has a shorter and distinct N-terminus, as compared to variant 1.
    Source sequence(s)
    AK123311, AK313658, BX648458, DA701390
    Consensus CDS
    CCDS33830.1
    UniProtKB/Swiss-Prot
    P17677
    UniProtKB/TrEMBL
    Q5U058
    Related
    ENSP00000305010.6, OTTHUMP00000165225, ENST00000305124.10, OTTHUMT00000258216
    Conserved Domains (2) summary
    smart00015
    Location:3052
    IQ; Calmodulin-binding motif
    pfam06614
    Location:67238
    Neuromodulin; Neuromodulin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    115623304..115721487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006128.1XP_016861617.1  neuromodulin isoform X1

    UniProtKB/Swiss-Prot
    P17677
    Conserved Domains (3) summary
    smart00015
    Location:6688
    IQ; Calmodulin-binding motif
    pfam06614
    Location:107274
    Neuromodulin; Neuromodulin
    pfam10310
    Location:89203
    DUF2413; Protein of unknown function (DUF2413)
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