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GPC1 glypican 1 [ Homo sapiens (human) ]

Gene ID: 2817, updated on 1-Jun-2020

Summary

Official Symbol
GPC1provided by HGNC
Official Full Name
glypican 1provided by HGNC
Primary source
HGNC:HGNC:4449
See related
Ensembl:ENSG00000063660 MIM:600395
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
glypican
Summary
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008]
Expression
Broad expression in skin (RPKM 51.0), testis (RPKM 21.8) and 19 other tissues See more
Orthologs

Genomic context

See GPC1 in Genome Data Viewer
Location:
2q37.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (240435663..240468076)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (241375115..241407495)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723825 Neighboring gene NFE2L2 motif-containing MPRA enhancer 30 Neighboring gene Sharpr-MPRA regulatory region 14717 Neighboring gene uncharacterized LOC100130449 Neighboring gene microRNA 149 Neighboring gene ankyrin repeat and MYND domain containing 1 Neighboring gene conserved acetylation island sequence C08 enhancer Neighboring gene dual specificity phosphatase 28 Neighboring gene arginyl aminopeptidase like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
capsid gag The interaction of HIV-1 CA with human cellular glypican 1 protein (GPC1) is identified by yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38078

Gene Ontology Provided by GOA

Function Evidence Code Pubs
copper ion binding IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fibroblast growth factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
laminin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
Schwann cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
axon guidance TAS
Traceable Author Statement
more info
 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycosaminoglycan biosynthetic process TAS
Traceable Author Statement
more info
 
glycosaminoglycan catabolic process TAS
Traceable Author Statement
more info
 
heparan sulfate proteoglycan catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
myelin assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of fibroblast growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of skeletal muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein localization to membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retinoid metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi lumen TAS
Traceable Author Statement
more info
 
anchored component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
collagen-containing extracellular matrix HDA PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular region HDA PubMed 
extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space TAS
Traceable Author Statement
more info
PubMed 
intrinsic component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
lysosomal lumen TAS
Traceable Author Statement
more info
 
colocalizes_with membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
glypican-1
Names
epididymis secretory sperm binding protein
glypican proteoglycan 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002081.3NP_002072.2  glypican-1 precursor

    See identical proteins and their annotated locations for NP_002072.2

    Status: REVIEWED

    Source sequence(s)
    AC110619, BG825129, X54232
    Consensus CDS
    CCDS2534.1
    UniProtKB/Swiss-Prot
    P35052
    Related
    ENSP00000264039.2, ENST00000264039.7
    Conserved Domains (1) summary
    pfam01153
    Location:22533
    Glypican; Glypican

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    240435663..240468076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510976.2XP_011509278.1  glypican-1 isoform X1

    UniProtKB/TrEMBL
    H7C410
    Related
    ENSP00000415077.2, ENST00000420138.5
    Conserved Domains (1) summary
    pfam01153
    Location:1461
    Glypican; Glypican
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