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GPC1 glypican 1 [ Homo sapiens (human) ]

Gene ID: 2817, updated on 3-Mar-2024

Summary

Official Symbol
GPC1provided by HGNC
Official Full Name
glypican 1provided by HGNC
Primary source
HGNC:HGNC:4449
See related
Ensembl:ENSG00000063660 MIM:600395; AllianceGenome:HGNC:4449
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
glypican
Summary
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008]
Expression
Broad expression in skin (RPKM 51.0), testis (RPKM 21.8) and 19 other tissues See more
Orthologs
NEW
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Genomic context

See GPC1 in Genome Data Viewer
Location:
2q37.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (240435663..240468076)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (240929356..240961704)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (241375080..241407493)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124906196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241230324-241231300 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241232276-241233251 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241264697-241265596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241293407-241294054 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:241294055-241294702 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:241301246-241301403 Neighboring gene VISTA enhancer hs1937 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241313445-241313999 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:241316604-241317104 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:241317105-241317605 Neighboring gene uncharacterized LOC102723825 Neighboring gene NFE2L2 motif-containing MPRA enhancer 30 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241338263-241338901 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241339542-241340180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241351335-241351920 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241366327-241366828 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241366829-241367328 Neighboring gene Sharpr-MPRA regulatory region 14717 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:241374143-241374719 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241376453-241377029 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241377081-241377582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12511 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:241394718-241395368 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:241397321-241397972 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:241397973-241398622 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:241398623-241399273 Neighboring gene GPC1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241417613-241418122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241418123-241418632 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241418633-241419142 Neighboring gene microRNA 149 Neighboring gene ankyrin repeat and MYND domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241439369-241439869 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241443459-241443959 Neighboring gene Sharpr-MPRA regulatory region 11390 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17396 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241467695-241468196 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12512 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241494599-241495099 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17397 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12513 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12515 Neighboring gene conserved acetylation island sequence C08 enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17399 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17400 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17401 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12516 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12517 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12518 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12519 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:241508348-241508986 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241508987-241509625 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17403 Neighboring gene Sharpr-MPRA regulatory region 11586 Neighboring gene dual specificity phosphatase 28 Neighboring gene arginyl aminopeptidase like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
capsid gag The interaction of HIV-1 CA with human cellular glypican 1 protein (GPC1) is identified by yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ38078

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables copper ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables fibroblast growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fibroblast growth factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables laminin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Schwann cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in heparan sulfate proteoglycan catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in myelin assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of fibroblast growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of skeletal muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of protein localization to membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in Golgi lumen TAS
Traceable Author Statement
more info
 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular region HDA PubMed 
located_in extracellular space TAS
Traceable Author Statement
more info
PubMed 
located_in lysosomal lumen TAS
Traceable Author Statement
more info
 
colocalizes_with membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
glypican-1
Names
epididymis secretory sperm binding protein
glypican proteoglycan 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002081.3NP_002072.2  glypican-1 precursor

    See identical proteins and their annotated locations for NP_002072.2

    Status: REVIEWED

    Source sequence(s)
    AC110619, BG825129, X54232
    Consensus CDS
    CCDS2534.1
    UniProtKB/Swiss-Prot
    B3KTD1, P35052, Q53QM4
    UniProtKB/TrEMBL
    A0A384NPH9
    Related
    ENSP00000264039.2, ENST00000264039.7
    Conserved Domains (1) summary
    pfam01153
    Location:22533
    Glypican

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    240435663..240468076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443961.1XP_047299917.1  glypican-1 isoform X1

    UniProtKB/TrEMBL
    H7C410
    Related
    ENSP00000415077.2, ENST00000420138.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    240929356..240961704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)