U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gpc1 glypican 1 [ Mus musculus (house mouse) ]

Gene ID: 14733, updated on 8-Feb-2024

Summary

Official Symbol
Gpc1provided by MGI
Official Full Name
glypican 1provided by MGI
Primary source
MGI:MGI:1194891
See related
Ensembl:ENSMUSG00000034220 AllianceGenome:MGI:1194891
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables fibroblast growth factor binding activity and laminin binding activity. Involved in negative regulation of fibroblast growth factor receptor signaling pathway. Acts upstream of or within positive regulation of skeletal muscle cell differentiation. Located in extracellular matrix; membrane raft; and synapse. Is expressed in several structures, including alimentary system; limb; metanephros; musculoskeletal system; and nervous system. Orthologous to human GPC1 (glypican 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 71.0), ovary adult (RPKM 35.4) and 20 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Gpc1 in Genome Data Viewer
Location:
1 D; 1 46.6 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (92759367..92787933)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (92831645..92860211)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 29483 Neighboring gene predicted gene, 36102 Neighboring gene VISTA enhancer mm1063 Neighboring gene predicted gene 29481 Neighboring gene predicted gene 29480 Neighboring gene microRNA 149 Neighboring gene ankyrin repeat and MYND domain containing 1 Neighboring gene RIKEN cDNA 5033417F24 gene Neighboring gene predicted gene, 57577 Neighboring gene dual specificity phosphatase 28

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables collagen V binding ISO
Inferred from Sequence Orthology
more info
 
enables copper ion binding ISO
Inferred from Sequence Orthology
more info
 
enables fibroblast growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fibroblast growth factor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables laminin binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi lumen TAS
Traceable Author Statement
more info
 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016696.5NP_057905.1  glypican-1 precursor

    See identical proteins and their annotated locations for NP_057905.1

    Status: VALIDATED

    Source sequence(s)
    AC131059
    Consensus CDS
    CCDS15177.1
    UniProtKB/Swiss-Prot
    Q9QZF2
    UniProtKB/TrEMBL
    Q3U379
    Related
    ENSMUSP00000047199.7, ENSMUST00000045970.8
    Conserved Domains (1) summary
    pfam01153
    Location:22538
    Glypican; Glypican

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    92759367..92787933
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529142.4XP_006529205.1  glypican-1 isoform X1

    See identical proteins and their annotated locations for XP_006529205.1

    Conserved Domains (1) summary
    pfam01153
    Location:1466
    Glypican