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Ing4 inhibitor of growth family, member 4 [ Mus musculus (house mouse) ]

Gene ID: 28019, updated on 10-Mar-2024

Summary

Official Symbol
Ing4provided by MGI
Official Full Name
inhibitor of growth family, member 4provided by MGI
Primary source
MGI:MGI:107307
See related
Ensembl:ENSMUSG00000030330 AllianceGenome:MGI:107307
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D6Xrf92; p29ING4; D6Wsu147e
Summary
Predicted to enable methylated histone binding activity and transcription coactivator activity. Involved in positive regulation of apoptotic process. Located in nucleus. Is expressed in several structures, including cerebral cortex; early conceptus; genitourinary system; sensory organ; and skeleton. Orthologous to human ING4 (inhibitor of growth family member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 43.3), CNS E14 (RPKM 42.0) and 28 other tissues See more
Orthologs
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Genomic context

See Ing4 in Genome Data Viewer
Location:
6 F2; 6 59.17 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (125016811..125026228)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (125039848..125049265)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene COP9 signalosome subunit 7A Neighboring gene STARR-positive B cell enhancer ABC_E6488 Neighboring gene RIKEN cDNA 4930557K07 gene Neighboring gene STARR-positive B cell enhancer ABC_E1711 Neighboring gene PILR alpha associated neural protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124959611-124959720 Neighboring gene zinc finger protein 384 Neighboring gene STARR-positive B cell enhancer ABC_E1071 Neighboring gene STARR-seq mESC enhancer starr_17323 Neighboring gene STARR-positive B cell enhancer ABC_E6489 Neighboring gene proacrosin binding protein Neighboring gene lysophosphatidic acid receptor 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to histone H3K14 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to histone H4K12 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to histone H4K5 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to histone H4K8 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA replication-dependent chromatin disassembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_negative_effect regulation of cell cycle G2/M phase transition ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
inhibitor of growth protein 4
Names
ING1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368695.1NP_001355624.1  inhibitor of growth protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC134529
    Consensus CDS
    CCDS90121.1
    UniProtKB/Swiss-Prot
    Q8C0D7, Q8C1S7, Q8K3Q5, Q8K3Q6, Q8K3Q7, Q9D7F9
    Related
    ENSMUSP00000121519.2, ENSMUST00000140131.8
    Conserved Domains (2) summary
    COG5034
    Location:7245
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd16862
    Location:11104
    ING_ING4; Inhibitor of growth (ING) domain of inhibitor of growth protein 4 (ING4)
  2. NM_133345.2NP_579923.1  inhibitor of growth protein 4 isoform 1

    See identical proteins and their annotated locations for NP_579923.1

    Status: VALIDATED

    Source sequence(s)
    AK009267
    Consensus CDS
    CCDS39632.1
    UniProtKB/Swiss-Prot
    Q8C0D7
    Related
    ENSMUSP00000032480.8, ENSMUST00000032480.14
    Conserved Domains (2) summary
    COG5034
    Location:7244
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd16862
    Location:11104
    ING_ING4; Inhibitor of growth (ING) domain of inhibitor of growth protein 4 (ING4)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    125016811..125026228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_144510.1: Suppressed sequence

    Description
    NM_144510.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.