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ING4 inhibitor of growth family member 4 [ Homo sapiens (human) ]

Gene ID: 51147, updated on 12-Oct-2019

Summary

Official Symbol
ING4provided by HGNC
Official Full Name
inhibitor of growth family member 4provided by HGNC
Primary source
HGNC:HGNC:19423
See related
Ensembl:ENSG00000111653 MIM:608524
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
my036; p29ING4
Summary
This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 15.7), endometrium (RPKM 14.9) and 25 other tissues See more
Orthologs

Genomic context

See ING4 in Genome Data Viewer
Location:
12p13.31
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (6650301..6663143, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6759704..6772311, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369631 Neighboring gene lysophosphatidic acid receptor 5 Neighboring gene acrosin binding protein Neighboring gene zinc finger protein 384 Neighboring gene PILR alpha associated neural protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
    Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
  • Chromatin organization, organism-specific biosystem (from REACTOME)
    Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
  • HATs acetylate histones, organism-specific biosystem (from REACTOME)
    HATs acetylate histones, organism-specific biosystemHistone acetyltransferases (HATs) involved in histone modifications are referred to as A-type or nuclear HATs. They can be grouped into at least four families based on sequence conservation within th...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC12557

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
inhibitor of growth protein 4
Names
brain my036 protein
candidate tumor suppressor p33 ING1 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047151.1 RefSeqGene

    Range
    5031..17849
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001127582.2NP_001121054.1  inhibitor of growth protein 4 isoform 9

    See identical proteins and their annotated locations for NP_001121054.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) represents the longest transcript and it encodes the longest protein (isoform 9). Another name for this variant is ING4_v1.
    Source sequence(s)
    AC135892, AF156552, AW614868, BP303219
    Consensus CDS
    CCDS44813.1
    UniProtKB/Swiss-Prot
    Q9UNL4
    Related
    ENSP00000380024.4, ENST00000396807.8
    Conserved Domains (2) summary
    cd15684
    Location:197244
    PHD_ING4; PHD finger found in inhibitor of growth protein 4 (ING4)
    pfam12998
    Location:6105
    ING; Inhibitor of growth proteins N-terminal histone-binding
  2. NM_001127583.2NP_001121055.1  inhibitor of growth protein 4 isoform 3

    See identical proteins and their annotated locations for NP_001121055.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses a different splice site in the coding region, compared to variant 9. The resulting protein (isoform 3) is shorter by 3 aa compared to isoform 9. Other names for this variant are ING4_v3 and "9 bp skip variant".
    Source sequence(s)
    AB197696, AC135892, AF156552, AW614868, BP303219
    Consensus CDS
    CCDS44814.1
    UniProtKB/Swiss-Prot
    Q9UNL4
    Related
    ENSP00000412705.2, ENST00000412586.6
    Conserved Domains (2) summary
    cd15684
    Location:194241
    PHD_ING4; PHD finger found in inhibitor of growth protein 4 (ING4)
    pfam12998
    Location:6105
    ING; Inhibitor of growth proteins N-terminal histone-binding
  3. NM_001127584.2NP_001121056.1  inhibitor of growth protein 4 isoform 4

    See identical proteins and their annotated locations for NP_001121056.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses a different splice site in the coding region, compared to variant 9. The resulting protein (isoform 4) is shorter by 4 aa compared to isoform 9. Other names for this variant are ING4_v4 and "12 bp skip variant".
    Source sequence(s)
    AB197697, AC135892, AF156552, AW614868, BP303219
    Consensus CDS
    CCDS44815.1
    UniProtKB/Swiss-Prot
    Q9UNL4
    Related
    ENSP00000415903.2, ENST00000446105.6
    Conserved Domains (2) summary
    cd15684
    Location:193240
    PHD_ING4; PHD finger found in inhibitor of growth protein 4 (ING4)
    pfam12998
    Location:6105
    ING; Inhibitor of growth proteins N-terminal histone-binding
  4. NM_001127585.2NP_001121057.1  inhibitor of growth protein 4 isoform 5

    See identical proteins and their annotated locations for NP_001121057.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate segment in the coding region, compared to variant 9. The resulting protein (isoform 5) is shorter when it is compared to isoform 9. Another name for this variant is delta Ex2.
    Source sequence(s)
    AC135892, AF156552, AW614868, BP303219, EF152349
    Consensus CDS
    CCDS44812.1
    UniProtKB/Swiss-Prot
    Q9UNL4
    Related
    ENSP00000397343.2, ENST00000444704.5
    Conserved Domains (2) summary
    cd15684
    Location:173220
    PHD_ING4; PHD finger found in inhibitor of growth protein 4 (ING4)
    cl26267
    Location:13221
    ING; Inhibitor of growth proteins N-terminal histone-binding
  5. NM_001127586.2NP_001121058.1  inhibitor of growth protein 4 isoform 6

    See identical proteins and their annotated locations for NP_001121058.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate segment in the 3' coding region. which changes the reading frame, compared to variant 9. The resulting protein (isoform 6) is shorter and has a distinct C-terminus when it is compared to isoform 9. Another name for this variant is delta Ex6A.
    Source sequence(s)
    AC135892, AF156552, AW614868, BP303219, EF152351
    Consensus CDS
    CCDS44816.1
    UniProtKB/Swiss-Prot
    Q9UNL4
    Related
    ENSP00000414008.2, ENST00000423703.6
    Conserved Domains (1) summary
    pfam12998
    Location:6105
    ING; Inhibitor of growth proteins N-terminal histone-binding
  6. NM_016162.4NP_057246.2  inhibitor of growth protein 4 isoform 1

    See identical proteins and their annotated locations for NP_057246.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses a different splice site in the coding region, compared to variant 9. The resulting protein (isoform 1) is shorter by 1 aa compared to isoform 9. Other names for this variant are ING4_v2 and "3 bp skip variant".
    Source sequence(s)
    AC135892, AW614868, BC095434, BP303219
    Consensus CDS
    CCDS8555.1
    UniProtKB/Swiss-Prot
    Q9UNL4
    Related
    ENSP00000343396.4, ENST00000341550.9
    Conserved Domains (2) summary
    cd15684
    Location:196243
    PHD_ING4; PHD finger found in inhibitor of growth protein 4 (ING4)
    pfam12998
    Location:6105
    ING; Inhibitor of growth proteins N-terminal histone-binding

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    6650301..6663143 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520964.2XP_011519266.1  inhibitor of growth protein 4 isoform X1

    Conserved Domains (2) summary
    cd15684
    Location:172219
    PHD_ING4; PHD finger found in inhibitor of growth protein 4 (ING4)
    pfam12998
    Location:681
    ING; Inhibitor of growth proteins N-terminal histone-binding
  2. XM_017019393.2XP_016874882.1  inhibitor of growth protein 4 isoform X5

  3. XM_017019392.2XP_016874881.1  inhibitor of growth protein 4 isoform X4

    Conserved Domains (2) summary
    cd15684
    Location:147194
    PHD_ING4; PHD finger found in inhibitor of growth protein 4 (ING4)
    pfam12998
    Location:156
    ING; Inhibitor of growth proteins N-terminal histone-binding
  4. XM_005253698.4XP_005253755.1  inhibitor of growth protein 4 isoform X3

    Conserved Domains (2) summary
    cd15684
    Location:148195
    PHD_ING4; PHD finger found in inhibitor of growth protein 4 (ING4)
    pfam12998
    Location:156
    ING; Inhibitor of growth proteins N-terminal histone-binding
  5. XM_011520965.3XP_011519267.1  inhibitor of growth protein 4 isoform X2

    See identical proteins and their annotated locations for XP_011519267.1

    Conserved Domains (2) summary
    cd15684
    Location:170217
    PHD_ING4; PHD finger found in inhibitor of growth protein 4 (ING4)
    cl26267
    Location:28218
    ING; Inhibitor of growth proteins N-terminal histone-binding

RNA

  1. XR_242983.3 RNA Sequence

  2. XR_002957334.1 RNA Sequence

  3. XR_242982.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198287.1: Suppressed sequence

    Description
    NM_198287.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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