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GNG10 G protein subunit gamma 10 [ Homo sapiens (human) ]

Gene ID: 2790, updated on 5-Aug-2022

Summary

Official Symbol
GNG10provided by HGNC
Official Full Name
G protein subunit gamma 10provided by HGNC
Primary source
HGNC:HGNC:4402
See related
Ensembl:ENSG00000242616 MIM:604389; AllianceGenome:HGNC:4402
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in appendix (RPKM 57.2), adrenal (RPKM 51.1) and 25 other tissues See more
Orthologs
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Genomic context

See GNG10 in Genome Data Viewer
Location:
9q31.3
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (111661605..111670226)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (123832965..123841586)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (114423885..114432506)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene DNAJC25-GNG10 readthrough Neighboring gene FOXA motif-containing MPRA enhancer 227 Neighboring gene Sharpr-MPRA regulatory region 12797 Neighboring gene DnaJ heat shock protein family (Hsp40) member C25 Neighboring gene Sharpr-MPRA regulatory region 3205 Neighboring gene shortage in chiasmata 1

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
Names
guanine nucleotide binding protein (G protein), gamma 10
guanine nucleotide binding protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017998.4NP_001017998.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10

    See identical proteins and their annotated locations for NP_001017998.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represent the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AW583403, BC107574, DB504443
    Consensus CDS
    CCDS35107.1
    UniProtKB/Swiss-Prot
    P50151, Q4VC27
    UniProtKB/TrEMBL
    A0A024R156
    Related
    ENSP00000363411.3, ENST00000374293.5
    Conserved Domains (1) summary
    cd00068
    Location:763
    GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors
  2. NM_001198664.2NP_001185593.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10

    See identical proteins and their annotated locations for NP_001185593.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL135787, AW583403, BC010384, DB504443
    Consensus CDS
    CCDS35107.1
    UniProtKB/Swiss-Prot
    P50151, Q4VC27
    UniProtKB/TrEMBL
    A0A024R156
    Conserved Domains (1) summary
    cd00068
    Location:763
    GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    111661605..111670226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    123832965..123841586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)