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Tango2 transport and golgi organization 2 [ Mus musculus (house mouse) ]

Gene ID: 27883, updated on 17-Aug-2024

Summary

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Official Symbol
Tango2provided by MGI
Official Full Name
transport and golgi organization 2provided by MGI
Primary source
MGI:MGI:101825
See related
Ensembl:ENSMUSG00000013539 AllianceGenome:MGI:101825
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
T10; D16H22S680E
Summary
Predicted to be involved in Golgi organization and protein secretion. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; branchial arch; cardiovascular system; and limb bud. Orthologous to human TANGO2 (transport and golgi organization 2 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 19.8), kidney adult (RPKM 10.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 A3; 16 11.34 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (18118689..18165962, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (18300825..18348098, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene DGCR8, microprocessor complex subunit Neighboring gene STARR-positive B cell enhancer ABC_E1921 Neighboring gene microRNA 1306 Neighboring gene microRNA 3618 Neighboring gene microRNA 185 Neighboring gene STARR-positive B cell enhancer ABC_E10891 Neighboring gene armadillo repeat gene deleted in velocardiofacial syndrome Neighboring gene STARR-seq mESC enhancer starr_40280 Neighboring gene predicted gene 15764 Neighboring gene catechol-O-methyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Bi-allelic Truncating Mutations in TANGO2 Cause Infancy-Onset Recurrent Metabolic Crises with Encephalocardiomyopathy. Kremer LS, et al. Am J Hum Genet, 2016 Feb 4. PMID 26805782, Free PMC Article
  2. A human gene similar to Drosophila melanogaster peanut maps to the DiGeorge syndrome region of 22q11. McKie JM, et al. Hum Genet, 1997 Nov. PMID 9385360
  3. Gene dosage in the developing and adult brain in a mouse model of 22q11 deletion syndrome. Meechan DW, et al. Mol Cell Neurosci, 2006 Dec. PMID 17097888
  4. Mitochondrial localization and function of a subset of 22q11 deletion syndrome candidate genes. Maynard TM, et al. Mol Cell Neurosci, 2008 Nov. PMID 18775783, Free PMC Article
  5. Cloning and comparative mapping of the DiGeorge syndrome critical region in the mouse. Sutherland HF, et al. Genomics, 1998 Aug 15. PMID 9740669

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transport and Golgi organization 2 homolog
Names
ser/Thr-rich protein T10 in DGCR region
transport and golgi organization 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359108.1 → NP_001346037.1  transport and Golgi organization 2 homolog isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform.
    Source sequence(s)
    AC084822
    Consensus CDS
    CCDS28019.1
    UniProtKB/Swiss-Prot
    P54797, Q8BTN3
    Conserved Domains (1) summary
    pfam05742
    Location:1 → 259
    TANGO2; Transport and Golgi organisation 2

  2. NM_001359109.1 → NP_001346038.1  transport and Golgi organization 2 homolog isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform.
    Source sequence(s)
    AC084822
    Consensus CDS
    CCDS28019.1
    UniProtKB/Swiss-Prot
    P54797, Q8BTN3
    Conserved Domains (1) summary
    pfam05742
    Location:1 → 259
    TANGO2; Transport and Golgi organisation 2

  3. NM_001359110.1 → NP_001346039.1  transport and Golgi organization 2 homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC084822
    Conserved Domains (1) summary
    pfam05742
    Location:2 → 208
    TANGO2; Transport and Golgi organisation 2

  4. NM_001359111.1 → NP_001346040.1  transport and Golgi organization 2 homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC084822
    Conserved Domains (1) summary
    pfam05742
    Location:2 → 208
    TANGO2; Transport and Golgi organisation 2

  5. NM_138583.2 → NP_613049.2  transport and Golgi organization 2 homolog isoform 1

    See identical proteins and their annotated locations for NP_613049.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 2, and 3 encode the same isoform.
    Source sequence(s)
    AI837283, AK168595, BY274949
    Consensus CDS
    CCDS28019.1
    UniProtKB/Swiss-Prot
    P54797, Q8BTN3
    Related
    ENSMUSP00000111291.3, ENSMUST00000115628.10
    Conserved Domains (1) summary
    pfam05742
    Location:1 → 259
    TANGO2; Transport and Golgi organisation 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    18118689..18165962 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522230.2 → XP_006522293.1  transport and Golgi organization 2 homolog isoform X2

    See identical proteins and their annotated locations for XP_006522293.1

    Conserved Domains (1) summary
    pfam05742
    Location:2 → 208
    TANGO2; Transport and Golgi organisation 2

  2. XM_036159979.1 → XP_036015872.1  transport and Golgi organization 2 homolog isoform X1

    UniProtKB/Swiss-Prot
    P54797, Q8BTN3
    Conserved Domains (1) summary
    pfam05742
    Location:1 → 259
    TANGO2; Transport and Golgi organisation 2

  3. XM_017317031.3 → XP_017172520.1  transport and Golgi organization 2 homolog isoform X1

    UniProtKB/Swiss-Prot
    P54797, Q8BTN3
    Conserved Domains (1) summary
    pfam05742
    Location:1 → 259
    TANGO2; Transport and Golgi organisation 2

  4. XM_036159978.1 → XP_036015871.1  transport and Golgi organization 2 homolog isoform X1

    UniProtKB/Swiss-Prot
    P54797, Q8BTN3
    Conserved Domains (1) summary
    pfam05742
    Location:1 → 259
    TANGO2; Transport and Golgi organisation 2

  5. XM_011245929.1 → XP_011244231.1  transport and Golgi organization 2 homolog isoform X1

    See identical proteins and their annotated locations for XP_011244231.1

    UniProtKB/Swiss-Prot
    P54797, Q8BTN3
    Conserved Domains (1) summary
    pfam05742
    Location:1 → 259
    TANGO2; Transport and Golgi organisation 2

RNA

  1. XR_384570.2 RNA Sequence

  2. XR_003951794.2 RNA Sequence

    Related
    ENSMUST00000128580.8

  3. XR_384571.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54797.2 GenPept UniProtKB/Swiss-Prot:P54797

Gene LinkOut

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