Format

Send to:

Choose Destination

TANGO2 transport and golgi organization 2 homolog [ Homo sapiens (human) ]

Gene ID: 128989, updated on 17-Dec-2019

Summary

Official Symbol
TANGO2provided by HGNC
Official Full Name
transport and golgi organization 2 homologprovided by HGNC
Primary source
HGNC:HGNC:25439
See related
Ensembl:ENSG00000183597 MIM:616830
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MECRCN; C22orf25
Summary
This gene belongs to the transport and Golgi organization family, whose members are predicted to play roles in secretory protein loading in the endoplasmic reticulum. Depletion of this gene in Drosophila S2 cells causes fusion of the Golgi with the ER. In mouse tissue culture cells, this protein co-localizes with a mitochondrially targeted mCherry protein and displays very low levels of co-localization with Golgi and peroxisomes. Allelic variants of this gene are associated with rhabdomyolysis, metabolic crises with encephalopathy, and cardiac arrhythmia. [provided by RefSeq, Apr 2016]
Expression
Ubiquitous expression in heart (RPKM 11.7), bone marrow (RPKM 9.2) and 25 other tissues See more
Orthologs

Genomic context

See TANGO2 in Genome Data Viewer
Location:
22q11.21
Exon count:
12
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (20017000..20067164)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (20004554..20053449)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene catechol-O-methyltransferase Neighboring gene microRNA 4761 Neighboring gene ARVCF delta catenin family member Neighboring gene microRNA 185 Neighboring gene DGCR8 microprocessor complex subunit Neighboring gene microRNA 3618 Neighboring gene microRNA 1306

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp761P1121

Gene Ontology Provided by GOA

Process Evidence Code Pubs
Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transport and Golgi organization protein 2 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046857.1 RefSeqGene

    Range
    5001..55165
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001283106.2NP_001270035.1  transport and Golgi organization protein 2 homolog isoform a

    See identical proteins and their annotated locations for NP_001270035.1

    Status: REVIEWED

    Source sequence(s)
    AA969089, AC006547, AK289862, BC041339, DC303300, HY135099
    Consensus CDS
    CCDS13772.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    UniProtKB/TrEMBL
    A8K1E7
    Conserved Domains (1) summary
    pfam05742
    Location:1259
    TANGO2; Transport and Golgi organization 2
  2. NM_001283116.2NP_001270045.1  transport and Golgi organization protein 2 homolog isoform a

    See identical proteins and their annotated locations for NP_001270045.1

    Status: REVIEWED

    Source sequence(s)
    AA969089, AC006547, BC041339, CF552364, DA176876, DC318353
    Consensus CDS
    CCDS13772.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    Conserved Domains (1) summary
    pfam05742
    Location:1259
    TANGO2; Transport and Golgi organization 2
  3. NM_001283129.2NP_001270058.1  transport and Golgi organization protein 2 homolog isoform b

    See identical proteins and their annotated locations for NP_001270058.1

    Status: REVIEWED

    Source sequence(s)
    AA969089, AC006547, AK316056, BC041339, DA176876, DC318353
    Consensus CDS
    CCDS63405.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    Related
    ENSP00000403645.2, ENST00000456048.5
    Conserved Domains (1) summary
    pfam05742
    Location:60300
    TANGO2; Transport and Golgi organization 2
  4. NM_001283148.2NP_001270077.1  transport and Golgi organization protein 2 homolog isoform c

    See identical proteins and their annotated locations for NP_001270077.1

    Status: REVIEWED

    Source sequence(s)
    AA969089, AC006547, AK316020, BC041339, DA176876, DC318353
    UniProtKB/Swiss-Prot
    Q6ICL3
    UniProtKB/TrEMBL
    B7Z9Q5
    Conserved Domains (1) summary
    pfam05742
    Location:1201
    TANGO2; Transport and Golgi organization 2
  5. NM_001283154.2NP_001270083.1  transport and Golgi organization protein 2 homolog isoform c

    See identical proteins and their annotated locations for NP_001270083.1

    Status: REVIEWED

    Source sequence(s)
    AA969089, AC006547, BC041339, BI544307, BU173566, DA176876, DC318353
    UniProtKB/Swiss-Prot
    Q6ICL3
    UniProtKB/TrEMBL
    B7Z9Q5
    Conserved Domains (1) summary
    pfam05742
    Location:1201
    TANGO2; Transport and Golgi organization 2
  6. NM_001283179.2NP_001270108.1  transport and Golgi organization protein 2 homolog isoform d

    See identical proteins and their annotated locations for NP_001270108.1

    Status: REVIEWED

    Source sequence(s)
    AA969089, AC006547, BC041339, BX345246, DC303300, HY135099
    Consensus CDS
    CCDS63404.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    Related
    ENSP00000385662.1, ENST00000401886.5
    Conserved Domains (1) summary
    pfam05742
    Location:1197
    TANGO2; Transport and Golgi organisation 2
  7. NM_001283186.2NP_001270115.1  transport and Golgi organization protein 2 homolog isoform d

    See identical proteins and their annotated locations for NP_001270115.1

    Status: REVIEWED

    Source sequence(s)
    AA969089, AC006547, AK092484, BC041339, DA176876, DC318353
    Consensus CDS
    CCDS63404.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    Related
    ENSP00000381122.2, ENST00000398042.6
    Conserved Domains (1) summary
    pfam05742
    Location:1197
    TANGO2; Transport and Golgi organisation 2
  8. NM_001283199.2NP_001270128.1  transport and Golgi organization protein 2 homolog isoform e

    Status: REVIEWED

    Source sequence(s)
    AA969089, AC006547, BC041339, BI544307, BI911898, DA176876, DC318353
    Consensus CDS
    CCDS74821.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    UniProtKB/TrEMBL
    A0A0A0MSI5
    Related
    ENSP00000389797.3, ENST00000447208.6
    Conserved Domains (1) summary
    pfam05742
    Location:1184
    TANGO2; Transport and Golgi organization 2
  9. NM_001283215.2NP_001270144.1  transport and Golgi organization protein 2 homolog isoform f

    See identical proteins and their annotated locations for NP_001270144.1

    Status: REVIEWED

    Source sequence(s)
    AA969089, AC006547, AK301366, AK316056, BC041339, DA176876, DC318353
    Consensus CDS
    CCDS63406.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    Related
    ENSP00000391262.2, ENST00000434570.6
    Conserved Domains (1) summary
    pfam05742
    Location:60192
    TANGO2; Transport and Golgi organization 2
  10. NM_001283235.2NP_001270164.1  transport and Golgi organization protein 2 homolog isoform g

    See identical proteins and their annotated locations for NP_001270164.1

    Status: REVIEWED

    Source sequence(s)
    AA969089, AC006547, AK298593, BC041339, DA176876, DC318353
    Consensus CDS
    CCDS63407.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    Related
    ENSP00000402926.2, ENST00000432883.5
    Conserved Domains (1) summary
    cl01315
    Location:32161
    TANGO2; Transport and Golgi organisation 2
  11. NM_001283248.2NP_001270177.1  transport and Golgi organization protein 2 homolog isoform h

    See identical proteins and their annotated locations for NP_001270177.1

    Status: REVIEWED

    Source sequence(s)
    AA969089, AC006547, AK297075, BC041339, DA176876, DC318353
    Consensus CDS
    CCDS74822.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    UniProtKB/TrEMBL
    B7Z4A5
    Related
    ENSP00000396182.3, ENST00000420290.6
    Conserved Domains (1) summary
    cl01315
    Location:189
    TANGO2; Transport and Golgi organization 2
  12. NM_001322141.1NP_001309070.1  transport and Golgi organization protein 2 homolog isoform i

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547, BG685068, BP193987
    Conserved Domains (1) summary
    pfam05742
    Location:60352
    TANGO2; Transport and Golgi organization 2
  13. NM_001322142.1NP_001309071.1  transport and Golgi organization protein 2 homolog isoform j

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547
    Conserved Domains (1) summary
    pfam05742
    Location:1311
    TANGO2; Transport and Golgi organization 2
  14. NM_001322143.1NP_001309072.1  transport and Golgi organization protein 2 homolog isoform b

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547, AL713640, BM013784, DB021425
    Consensus CDS
    CCDS63405.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    Related
    ENSP00000384827.1, ENST00000401833.5
    Conserved Domains (1) summary
    pfam05742
    Location:60300
    TANGO2; Transport and Golgi organization 2
  15. NM_001322144.1NP_001309073.1  transport and Golgi organization protein 2 homolog isoform l

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547
    Conserved Domains (1) summary
    pfam05742
    Location:60242
    TANGO2; Transport and Golgi organization 2
  16. NM_001322145.1NP_001309074.1  transport and Golgi organization protein 2 homolog isoform m

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547
    Conserved Domains (1) summary
    pfam05742
    Location:60238
    TANGO2; Transport and Golgi organization 2
  17. NM_001322146.1NP_001309075.1  transport and Golgi organization protein 2 homolog isoform k

    Status: REVIEWED

    Source sequence(s)
    AA319727, AC005663, AC006547
    Conserved Domains (1) summary
    pfam05742
    Location:55277
    TANGO2; Transport and Golgi organization 2
  18. NM_001322147.1NP_001309076.1  transport and Golgi organization protein 2 homolog isoform m

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547
    Conserved Domains (1) summary
    pfam05742
    Location:60238
    TANGO2; Transport and Golgi organization 2
  19. NM_001322148.1NP_001309077.1  transport and Golgi organization protein 2 homolog isoform n

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547, AK316056, BM048105
    UniProtKB/Swiss-Prot
    Q6ICL3
    Conserved Domains (1) summary
    pfam05742
    Location:55225
    TANGO2; Transport and Golgi organization 2
  20. NM_001322149.1NP_001309078.1  transport and Golgi organization protein 2 homolog isoform r

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547, BI911898, DC349456
    Conserved Domains (1) summary
    pfam05742
    Location:60225
    TANGO2; Transport and Golgi organization 2
  21. NM_001322150.1NP_001309079.1  transport and Golgi organization protein 2 homolog isoform o

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547, BP193987
    Conserved Domains (1) summary
    cl01315
    Location:32213
    TANGO2; Transport and Golgi organization 2
  22. NM_001322153.1NP_001309082.1  transport and Golgi organization protein 2 homolog isoform o

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547, DC301369, DC315148
    Conserved Domains (1) summary
    cl01315
    Location:32213
    TANGO2; Transport and Golgi organization 2
  23. NM_001322155.1NP_001309084.1  transport and Golgi organization protein 2 homolog isoform o

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547
    Conserved Domains (1) summary
    cl01315
    Location:32213
    TANGO2; Transport and Golgi organization 2
  24. NM_001322160.1NP_001309089.1  transport and Golgi organization protein 2 homolog isoform p

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547
    Conserved Domains (1) summary
    cl01315
    Location:55167
    TANGO2; Transport and Golgi organization 2
  25. NM_001322163.1NP_001309092.1  transport and Golgi organization protein 2 homolog isoform d

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547
    Consensus CDS
    CCDS63404.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    Conserved Domains (1) summary
    pfam05742
    Location:1197
    TANGO2; Transport and Golgi organisation 2
  26. NM_001322166.1NP_001309095.1  transport and Golgi organization protein 2 homolog isoform d

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547
    Consensus CDS
    CCDS63404.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    Conserved Domains (1) summary
    pfam05742
    Location:1197
    TANGO2; Transport and Golgi organisation 2
  27. NM_001322167.1NP_001309096.1  transport and Golgi organization protein 2 homolog isoform d

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547
    Consensus CDS
    CCDS63404.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    Conserved Domains (1) summary
    pfam05742
    Location:1197
    TANGO2; Transport and Golgi organisation 2
  28. NM_001322169.1NP_001309098.1  transport and Golgi organization protein 2 homolog isoform q

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547
    Conserved Domains (1) summary
    pfam05742
    Location:1139
    TANGO2; Transport and Golgi organization 2
  29. NM_001322171.1NP_001309100.1  transport and Golgi organization protein 2 homolog isoform g

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547, BF726547, CD675132
    Consensus CDS
    CCDS63407.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    Conserved Domains (1) summary
    cl01315
    Location:32161
    TANGO2; Transport and Golgi organisation 2
  30. NM_001322172.1NP_001309101.1  transport and Golgi organization protein 2 homolog isoform g

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547, BF726547
    Consensus CDS
    CCDS63407.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    Conserved Domains (1) summary
    cl01315
    Location:32161
    TANGO2; Transport and Golgi organisation 2
  31. NM_001322173.1NP_001309102.1  transport and Golgi organization protein 2 homolog isoform g

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547
    Consensus CDS
    CCDS63407.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    Conserved Domains (1) summary
    cl01315
    Location:32161
    TANGO2; Transport and Golgi organisation 2
  32. NM_001322174.1NP_001309103.1  transport and Golgi organization protein 2 homolog isoform g

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547
    Consensus CDS
    CCDS63407.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    Conserved Domains (1) summary
    cl01315
    Location:32161
    TANGO2; Transport and Golgi organisation 2
  33. NM_001322175.1NP_001309104.1  transport and Golgi organization protein 2 homolog isoform g

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547
    Consensus CDS
    CCDS63407.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    Conserved Domains (1) summary
    cl01315
    Location:32161
    TANGO2; Transport and Golgi organisation 2
  34. NM_152906.7NP_690870.3  transport and Golgi organization protein 2 homolog isoform a

    See identical proteins and their annotated locations for NP_690870.3

    Status: REVIEWED

    Source sequence(s)
    AA969089, AC006547, AK297922, BC041339
    Consensus CDS
    CCDS13772.1
    UniProtKB/Swiss-Prot
    Q6ICL3
    UniProtKB/TrEMBL
    B7Z4V5
    Related
    ENSP00000332721.4, ENST00000327374.9
    Conserved Domains (1) summary
    pfam05742
    Location:1259
    TANGO2; Transport and Golgi organization 2

RNA

  1. NR_104274.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AA969089, AC006547, AK301054, BC041339, DA176876, DC318353
  2. NR_104275.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547
  3. NR_136206.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547
  4. NR_136211.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC006547, BI544307, BP303570
  5. NR_136212.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005663, AC006547

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    20017000..20067164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028581.1XP_016884070.1  transport and Golgi organization protein 2 homolog isoform X2

    Conserved Domains (1) summary
    pfam05742
    Location:55277
    TANGO2; Transport and Golgi organization 2
  2. XM_017028587.1XP_016884076.1  transport and Golgi organization protein 2 homolog isoform X4

    Conserved Domains (1) summary
    pfam05742
    Location:55225
    TANGO2; Transport and Golgi organization 2
  3. XM_017028579.1XP_016884068.1  transport and Golgi organization protein 2 homolog isoform X1

    Conserved Domains (1) summary
    pfam05742
    Location:1311
    TANGO2; Transport and Golgi organization 2
  4. XM_017028582.1XP_016884071.1  transport and Golgi organization protein 2 homolog isoform X2

    Conserved Domains (1) summary
    pfam05742
    Location:55277
    TANGO2; Transport and Golgi organization 2
  5. XM_017028580.1XP_016884069.1  transport and Golgi organization protein 2 homolog isoform X1

    Conserved Domains (1) summary
    pfam05742
    Location:1311
    TANGO2; Transport and Golgi organization 2
  6. XM_011529867.1XP_011528169.1  transport and Golgi organization protein 2 homolog isoform X7

    See identical proteins and their annotated locations for XP_011528169.1

    UniProtKB/Swiss-Prot
    Q6ICL3
    Conserved Domains (1) summary
    cl01315
    Location:32161
    TANGO2; Transport and Golgi organisation 2
  7. XM_017028586.1XP_016884075.1  transport and Golgi organization protein 2 homolog isoform X3

  8. XM_017028584.1XP_016884073.1  transport and Golgi organization protein 2 homolog isoform X2

    Conserved Domains (1) summary
    pfam05742
    Location:55277
    TANGO2; Transport and Golgi organization 2
  9. XM_011529863.1XP_011528165.1  transport and Golgi organization protein 2 homolog isoform X5

    Conserved Domains (1) summary
    cl01315
    Location:55167
    TANGO2; Transport and Golgi organization 2
  10. XM_017028577.1XP_016884066.1  transport and Golgi organization protein 2 homolog isoform X1

    Conserved Domains (1) summary
    pfam05742
    Location:1311
    TANGO2; Transport and Golgi organization 2
  11. XM_017028585.1XP_016884074.1  transport and Golgi organization protein 2 homolog isoform X3

  12. XM_017028583.1XP_016884072.1  transport and Golgi organization protein 2 homolog isoform X2

    Conserved Domains (1) summary
    pfam05742
    Location:55277
    TANGO2; Transport and Golgi organization 2
  13. XM_017028588.2XP_016884077.1  transport and Golgi organization protein 2 homolog isoform X8

    Related
    ENSP00000415450.1, ENST00000450664.5
    Conserved Domains (1) summary
    pfam05742
    Location:1151
    TANGO2; Transport and Golgi organization 2
  14. XM_017028578.1XP_016884067.1  transport and Golgi organization protein 2 homolog isoform X1

    Conserved Domains (1) summary
    pfam05742
    Location:1311
    TANGO2; Transport and Golgi organization 2
  15. XM_024452157.1XP_024307925.1  transport and Golgi organization protein 2 homolog isoform X7

    Conserved Domains (1) summary
    cl01315
    Location:32161
    TANGO2; Transport and Golgi organisation 2
  16. XM_011529865.1XP_011528167.1  transport and Golgi organization protein 2 homolog isoform X6

    Conserved Domains (1) summary
    pfam05742
    Location:24156
    TANGO2; Transport and Golgi organization 2

RNA

  1. XR_001755164.1 RNA Sequence

    Related
    ENST00000399807.7
  2. XR_002958662.1 RNA Sequence

  3. XR_001755161.1 RNA Sequence

  4. XR_001755163.1 RNA Sequence

  5. XR_001755162.1 RNA Sequence

Support Center