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GNG4 G protein subunit gamma 4 [ Homo sapiens (human) ]

Gene ID: 2786, updated on 16-May-2020

Summary

Official Symbol
GNG4provided by HGNC
Official Full Name
G protein subunit gamma 4provided by HGNC
Primary source
HGNC:HGNC:4407
See related
Ensembl:ENSG00000168243 MIM:604388
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in brain (RPKM 11.8), ovary (RPKM 8.0) and 8 other tissues See more
Orthologs

Genomic context

See GNG4 in Genome Data Viewer
Location:
1q42.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (235547685..235650754, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (235710985..235814054, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MT-CO3 pseudogene 46 Neighboring gene MT-ND3 pseudogene 8 Neighboring gene solute carrier family 39 member 14 pseudogene Neighboring gene lysosomal trafficking regulator Neighboring gene lactate dehydrogenase A pseudogene 2 Neighboring gene microRNA 1537

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23803, FLJ34187, DKFZp547K1018

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
G-protein beta/gamma-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
Names
guanine nucleotide binding protein (G protein), gamma 4
guanine nucleotide binding protein 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098721.1NP_001092191.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4

    See identical proteins and their annotated locations for NP_001092191.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK074383, AK311781, BC022485, DA230013, FO393422
    Consensus CDS
    CCDS1607.1
    UniProtKB/Swiss-Prot
    P50150
    UniProtKB/TrEMBL
    B1APZ0
    Related
    ENSP00000398629.1, ENST00000450593.5
    Conserved Domains (1) summary
    smart00224
    Location:1375
    GGL; G protein gamma subunit-like motifs
  2. NM_001098722.2NP_001092192.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4

    See identical proteins and their annotated locations for NP_001092192.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK074383, AK311781, CX784976, FO393422
    Consensus CDS
    CCDS1607.1
    UniProtKB/Swiss-Prot
    P50150
    UniProtKB/TrEMBL
    B1APZ0
    Related
    ENSP00000375727.2, ENST00000391854.7
    Conserved Domains (1) summary
    smart00224
    Location:1375
    GGL; G protein gamma subunit-like motifs
  3. NM_004485.4NP_004476.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4

    See identical proteins and their annotated locations for NP_004476.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK074383, BC022485, FO393422
    Consensus CDS
    CCDS1607.1
    UniProtKB/Swiss-Prot
    P50150
    UniProtKB/TrEMBL
    B1APZ0
    Related
    ENSP00000355557.4, ENST00000366598.8
    Conserved Domains (1) summary
    smart00224
    Location:1375
    GGL; G protein gamma subunit-like motifs

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    235547685..235650754 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544167.2XP_011542469.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 isoform X1

    See identical proteins and their annotated locations for XP_011542469.1

    UniProtKB/Swiss-Prot
    P50150
    UniProtKB/TrEMBL
    B1APZ0
    Related
    ENSP00000482192.1, ENST00000484517.2
    Conserved Domains (1) summary
    smart00224
    Location:1375
    GGL; G protein gamma subunit-like motifs
  2. XM_006711761.2XP_006711824.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 isoform X1

    See identical proteins and their annotated locations for XP_006711824.1

    UniProtKB/Swiss-Prot
    P50150
    UniProtKB/TrEMBL
    B1APZ0
    Conserved Domains (1) summary
    smart00224
    Location:1375
    GGL; G protein gamma subunit-like motifs

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_014040927.1 Reference GRCh38.p13 PATCHES

    Range
    191277..195835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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