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Gng4 guanine nucleotide binding protein (G protein), gamma 4 [ Mus musculus (house mouse) ]

Gene ID: 14706, updated on 2-Nov-2024

Summary

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Official Symbol
Gng4provided by MGI
Official Full Name
guanine nucleotide binding protein (G protein), gamma 4provided by MGI
Primary source
MGI:MGI:102703
See related
Ensembl:ENSMUSG00000021303 AllianceGenome:MGI:102703
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hg3c
Summary
This gene encodes the gamma subunit of the heterotrimeric G-proteins that are comprised of alpha, beta and gamma subunits. Upon activation by G protein-coupled receptors, the beta-gamma heterodimer dissociates from the alpha subunit to activate downstream signaling events. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Expression
Biased expression in frontal lobe adult (RPKM 69.2), CNS E18 (RPKM 22.4) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Gng4 in Genome Data Viewer
Location:
13 A1; 13 5.29 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (13958644..14002480)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (13784059..13827895)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene nidogen 1 Neighboring gene STARR-positive B cell enhancer ABC_E11531 Neighboring gene STARR-seq mESC enhancer starr_33691 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:13656913-13657141 Neighboring gene STARR-positive B cell enhancer ABC_E1868 Neighboring gene predicted gene, 30836 Neighboring gene lysosomal trafficking regulator Neighboring gene STARR-seq mESC enhancer starr_33693 Neighboring gene STARR-seq mESC enhancer starr_33694 Neighboring gene STARR-seq mESC enhancer starr_33698 Neighboring gene STARR-seq mESC enhancer starr_33699 Neighboring gene STARR-seq mESC enhancer starr_33701 Neighboring gene STARR-seq mESC enhancer starr_33703 Neighboring gene predicted gene 7441 Neighboring gene STARR-seq mESC enhancer starr_33704 Neighboring gene STARR-positive B cell enhancer ABC_E5368 Neighboring gene heterogeneous nuclear ribonucleoprotein F pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A brain-specific G protein gamma subunit. Kalyanaraman S, et al. Biochem Biophys Res Commun, 1995 Nov 2. PMID 7488078
  2. A disulphide-linked heterodimer of TWIK-1 and TREK-1 mediates passive conductance in astrocytes. Hwang EM, et al. Nat Commun, 2014. PMID 24496152
  3. Selectivity in signal transduction determined by gamma subunits of heterotrimeric G proteins. Kleuss C, et al. Science, 1993 Feb 5. PMID 8094261
  4. Structure and chromosomal localization of mouse G protein subunit gamma 4 gene. Kalyanaraman S, et al. Genomics, 1998 Apr 1. PMID 9570961
  5. G protein diversity is increased by associations with a variety of gamma subunits. Gautam N, et al. Proc Natl Acad Sci U S A, 1990 Oct. PMID 2122451, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G-protein beta-subunit binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in negative regulation of cell growth IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of heterotrimeric G-protein complex ISA
Inferred from Sequence Alignment
more info
 PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
Names
heterotrimeric guanine nucleotide-binding protein 3c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302997.1 → NP_001289926.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 precursor

    See identical proteins and their annotated locations for NP_001289926.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC171200
    Consensus CDS
    CCDS36598.1
    UniProtKB/Swiss-Prot
    P50153
    UniProtKB/TrEMBL
    Q3UFJ8
    Conserved Domains (1) summary
    smart00224
    Location:13 → 75
    GGL; G protein gamma subunit-like motifs

  2. NM_010317.3 → NP_034447.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 precursor

    See identical proteins and their annotated locations for NP_034447.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC171200, BC016506
    Consensus CDS
    CCDS36598.1
    UniProtKB/Swiss-Prot
    P50153
    UniProtKB/TrEMBL
    Q3UFJ8
    Related
    ENSMUSP00000021734.8, ENSMUST00000021734.9
    Conserved Domains (1) summary
    smart00224
    Location:13 → 75
    GGL; G protein gamma subunit-like motifs

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    13958644..14002480
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50153.1 GenPept UniProtKB/Swiss-Prot:P50153

Gene LinkOut

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