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GNG3 G protein subunit gamma 3 [ Homo sapiens (human) ]

Gene ID: 2785, updated on 24-Nov-2020

Summary

Official Symbol
GNG3provided by HGNC
Official Full Name
G protein subunit gamma 3provided by HGNC
Primary source
HGNC:HGNC:4405
See related
Ensembl:ENSG00000162188 MIM:608941
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The gamma subunit determines the specificity of which signaling pathways will be affected by this particular complex. The protein encoded by this gene represents the gamma subunit of both inhibitory and stimulatory complexes. [provided by RefSeq, Jan 2012]
Expression
Biased expression in brain (RPKM 92.3), adrenal (RPKM 8.1) and 1 other tissue See more
Orthologs

Genomic context

See GNG3 in Genome Data Viewer
Location:
11q12.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (62707255..62709206)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62475066..62476678)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene UBX domain protein 1 Neighboring gene HNRNPUL2-BSCL2 readthrough (NMD candidate) Neighboring gene LRRN4 C-terminal like Neighboring gene BSCL2 lipid droplet biogenesis associated, seipin Neighboring gene heterogeneous nuclear ribonucleoprotein U like 2 Neighboring gene tetratricopeptide repeat domain 9C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of guanine nucleotide binding protein (G protein), gamma 3 (GNG3) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of MAPK activity TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
G-protein beta/gamma-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell body IEA
Inferred from Electronic Annotation
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
Names
NBP gamma-3
guanine nucleotide binding protein (G protein), gamma 3
guanine nucleotide-binding protein gamma-3 subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012202.5NP_036334.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3

    See identical proteins and their annotated locations for NP_036334.1

    Status: REVIEWED

    Source sequence(s)
    AF087900, AF092129, AP001458, DA123305
    Consensus CDS
    CCDS8032.1
    UniProtKB/Swiss-Prot
    P63215
    Related
    ENSP00000294117.5, ENST00000294117.6
    Conserved Domains (1) summary
    smart00224
    Location:1375
    GGL; G protein gamma subunit-like motifs

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    62707255..62709206
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718500.2XP_006718563.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X1

    See identical proteins and their annotated locations for XP_006718563.1

    UniProtKB/Swiss-Prot
    P63215
    Conserved Domains (1) summary
    smart00224
    Location:1375
    GGL; G protein gamma subunit-like motifs
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