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Gng3 guanine nucleotide binding protein (G protein), gamma 3 [ Mus musculus (house mouse) ]

Gene ID: 14704, updated on 18-Sep-2024

Summary

Official Symbol
Gng3provided by MGI
Official Full Name
guanine nucleotide binding protein (G protein), gamma 3provided by MGI
Primary source
MGI:MGI:102704
See related
Ensembl:ENSMUSG00000071658 AllianceGenome:MGI:102704
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hg3d
Summary
Predicted to enable G-protein beta-subunit binding activity and GTPase activity. Predicted to be involved in G protein-coupled receptor signaling pathway and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within signal transduction. Located in cell body; dendrite; and postsynaptic density. Is expressed in several structures, including gut; nervous system; oocyte; renal vasculature; and sensory organ. Orthologous to human GNG3 (G protein subunit gamma 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 101.4), cortex adult (RPKM 71.8) and 7 other tissues See more
Orthologs
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Genomic context

See Gng3 in Genome Data Viewer
Location:
19 A; 19 5.76 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8814293..8816610, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8836929..8839246, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 3 Neighboring gene tetratricopeptide repeat domain 9C Neighboring gene STARR-seq mESC enhancer starr_45496 Neighboring gene heterogeneous nuclear ribonucleoprotein U-like 2 Neighboring gene BSCL2 lipid droplet biogenesis associated, seipin Neighboring gene LRRN4 C-terminal like Neighboring gene STARR-seq mESC enhancer starr_45500 Neighboring gene UBX domain protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Related articles in PubMed

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G-protein beta-subunit binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity ISA
Inferred from Sequence Alignment
more info
PubMed 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
located_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of heterotrimeric G-protein complex ISA
Inferred from Sequence Alignment
more info
PubMed 
part_of heterotrimeric G-protein complex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
Names
guanine nucleotide binding protein (G protein), gamma 3 subunit
heterotrimeric guanine nucleotide-binding protein 3d

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010316.3NP_034446.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3

    See identical proteins and their annotated locations for NP_034446.1

    Status: VALIDATED

    Source sequence(s)
    AK032646, BE949484, BY290040
    Consensus CDS
    CCDS29550.1
    UniProtKB/Swiss-Prot
    P63216
    Related
    ENSMUSP00000093978.5, ENSMUST00000096259.6
    Conserved Domains (1) summary
    smart00224
    Location:1375
    GGL; G protein gamma subunit-like motifs

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    8814293..8816610 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)