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GLO1 glyoxalase I [ Homo sapiens (human) ]

Gene ID: 2739, updated on 7-Jan-2018
Official Symbol
GLO1provided by HGNC
Official Full Name
glyoxalase Iprovided by HGNC
Primary source
HGNC:HGNC:4323
See related
Ensembl:ENSG00000124767 MIM:138750; Vega:OTTHUMG00000014636
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLYI; GLOD1; HEL-S-74
Summary
The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in prostate (RPKM 115.6), duodenum (RPKM 59.9) and 24 other tissues See more
Orthologs
Location:
6p21.2
Exon count:
6
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (38675925..38703176, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (38643701..38670952, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene BTB domain containing 9 Neighboring gene TRK-fused gene pseudogene Neighboring gene uncharacterized LOC105375044 Neighboring gene RNA, 7SL, cytoplasmic 465, pseudogene Neighboring gene dynein axonemal heavy chain 8 Neighboring gene DnaJ heat shock protein family (Hsp40) member C2 pseudogene

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of glyoxalase I (GLO1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lactoylglutathione lyase activity IDA
Inferred from Direct Assay
more info
PubMed 
lactoylglutathione lyase activity TAS
Traceable Author Statement
more info
 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
glutathione metabolic process IEA
Inferred from Electronic Annotation
more info
 
methylglyoxal metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
osteoclast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
pyruvate metabolic process TAS
Traceable Author Statement
more info
 
regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
Preferred Names
lactoylglutathione lyase
Names
S-D-lactoylglutathione methylglyoxal lyase
aldoketomutase
epididymis secretory protein Li 74
glx I
glyoxalase domain containing 1
ketone-aldehyde mutase
lactoyl glutathione lyase
methylglyoxalase
NP_006699.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012074.1 RefSeqGene

    Range
    5001..32252
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006708.2NP_006699.2  lactoylglutathione lyase

    See identical proteins and their annotated locations for NP_006699.2

    Status: REVIEWED

    Source sequence(s)
    BC011365, BU954454, DA342581
    Consensus CDS
    CCDS4837.1
    UniProtKB/Swiss-Prot
    Q04760
    UniProtKB/TrEMBL
    X5DNM4
    Related
    ENSP00000362463.3, OTTHUMP00000016339, ENST00000373365.4, OTTHUMT00000040438
    Conserved Domains (1) summary
    cl14632
    Location:20183
    VOC; vicinal oxygen chelate (VOC) family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

    Range
    38675925..38703176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    38645758..38673043 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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