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Glo1 glyoxalase 1 [ Mus musculus (house mouse) ]

Gene ID: 109801, updated on 5-Aug-2018

Summary

Official Symbol
Glo1provided by MGI
Official Full Name
glyoxalase 1provided by MGI
Primary source
MGI:MGI:95742
See related
Ensembl:ENSMUSG00000024026
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GLY1; Qglo; Glo-1; Glo-1r; Glo-1s; Glo1-r; Glo1-s; AW550643; 0610009E22Rik; 1110008E19Rik; 2510049H23Rik
Expression
Ubiquitous expression in liver adult (RPKM 62.5), liver E18 (RPKM 45.7) and 28 other tissues See more
Orthologs

Genomic context

See Glo1 in Genome Data Viewer
Location:
17 A3.3; 17 15.69 cM
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (30592861..30612659, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (30729806..30749604, complement)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene zinc finger, AN1-type domain 3 Neighboring gene tubulin alpha, related sequence 1 Neighboring gene BTB (POZ) domain containing 9 Neighboring gene ribosomal protein S17 pseudogene Neighboring gene 40S ribosomal protein S13 pseudogene Neighboring gene RIKEN cDNA 1700097N02 gene Neighboring gene dynein, axonemal, heavy chain 8 Neighboring gene predicted gene, 41561

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
lactoylglutathione lyase activity IDA
Inferred from Direct Assay
more info
PubMed 
lactoylglutathione lyase activity ISO
Inferred from Sequence Orthology
more info
 
lyase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
carbohydrate metabolic process ISO
Inferred from Sequence Orthology
more info
 
glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
 
methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IC
Inferred by Curator
more info
PubMed 
methylglyoxal metabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
lactoylglutathione lyase
Names
S-D-lactoylglutathione methylglyoxal lyase
aldoketomutase
glx I
glyoxalase 1 complex
glyoxalase 1 regulatory
glyoxalase 1 structural
glyoxalase I
ketone-aldehyde mutase
methylglyoxalase
NP_001107032.1
NP_079650.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113560.1NP_001107032.1  lactoylglutathione lyase

    See identical proteins and their annotated locations for NP_001107032.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK049703, BG077218, BP769280, BY312309
    Consensus CDS
    CCDS28600.1
    UniProtKB/Swiss-Prot
    Q9CPU0
    UniProtKB/TrEMBL
    A5GZX3
    Related
    ENSMUSP00000126586.1, ENSMUST00000167624.1
    Conserved Domains (1) summary
    PLN03042
    Location:20184
    PLN03042; Lactoylglutathione lyase; Provisional
  2. NM_025374.3NP_079650.3  lactoylglutathione lyase

    See identical proteins and their annotated locations for NP_079650.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK049703, BP769280, BY312309
    Consensus CDS
    CCDS28600.1
    UniProtKB/Swiss-Prot
    Q9CPU0
    UniProtKB/TrEMBL
    A5GZX3
    Related
    ENSMUSP00000024823.6, ENSMUST00000024823.12
    Conserved Domains (1) summary
    PLN03042
    Location:20184
    PLN03042; Lactoylglutathione lyase; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

    Range
    30592861..30612659 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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