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Glo1 glyoxalase 1 [ Mus musculus (house mouse) ]

Gene ID: 109801, updated on 2-Nov-2024

Summary

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Official Symbol
Glo1provided by MGI
Official Full Name
glyoxalase 1provided by MGI
Primary source
MGI:MGI:95742
See related
Ensembl:ENSMUSG00000024026 AllianceGenome:MGI:95742
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GLY1; Qglo; Glo-1; Glo-1r; Glo-1s; Glo1-r; Glo1-s; 0610009E22Rik; 1110008E19Rik; 2510049H23Rik
Summary
Enables lactoylglutathione lyase activity and zinc ion binding activity. Involved in osteoclast differentiation. Acts upstream of or within regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in autistic disorder; diabetic retinopathy; end stage renal disease; type 2 diabetes mellitus; and vascular disease. Orthologous to human GLO1 (glyoxalase I). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver adult (RPKM 62.5), liver E18 (RPKM 45.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Glo1 in Genome Data Viewer
Location:
17 A3.3; 17 15.69 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (30811835..30831633, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (30592861..30612659, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene BTB domain containing 9 Neighboring gene predicted gene, 25049 Neighboring gene ribosomal protein S17 pseudogene Neighboring gene VISTA enhancer mm1326 Neighboring gene STARR-positive B cell enhancer ABC_E2480 Neighboring gene STARR-positive B cell enhancer ABC_E8666 Neighboring gene RIKEN cDNA 1700097N02 gene Neighboring gene 40S ribosomal protein S13 pseudogene Neighboring gene dynein, axonemal, heavy chain 8 Neighboring gene predicted gene, 24661

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Assignment of the gene for glyoxylase I to mouse chromosome 17 by somatic cell genetics. Leinwand L, et al. Biochem Genet, 1978 Aug. PMID 569476
  2. Ethyl pyruvate and ethyl lactate down-regulate the production of pro-inflammatory cytokines and modulate expression of immune receptors. Hollenbach M, et al. Biochem Pharmacol, 2008 Sep 1. PMID 18625205
  3. Structural basis for 18-β-glycyrrhetinic acid as a novel non-GSH analog glyoxalase I inhibitor. Zhang H, et al. Acta Pharmacol Sin, 2015 Sep. PMID 26279158, Free PMC Article
  4. Genetic and pharmacological manipulation of glyoxalase 1 regulates voluntary ethanol consumption in mice. McMurray KM, et al. Addict Biol, 2017 Mar. PMID 26691867, Free PMC Article
  5. A Glyoxalase-1 Knockdown Does Not Have Major Short Term Effects on Energy Expenditure and Atherosclerosis in Mice. Wortmann M, et al. J Diabetes Res, 2016. PMID 26788517, Free PMC Article

See all (113) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpressing glyoxalase 1 attenuates acute hyperglycemia-exacerbated neurological deficits of ischemic stroke in mice.
    Title: Overexpressing glyoxalase 1 attenuates acute hyperglycemia-exacerbated neurological deficits of ischemic stroke in mice.
  2. Glyoxalase 1 knockdown induces age-related beta-cell dysfunction and glucose intolerance in mice.
    Title: Glyoxalase 1 knockdown induces age-related β-cell dysfunction and glucose intolerance in mice.
  3. Combined glyoxalase 1 dysfunction and vitamin B6 deficiency in a schizophrenia model system causes mitochondrial dysfunction in the prefrontal cortex.
    Title: Combined glyoxalase 1 dysfunction and vitamin B6 deficiency in a schizophrenia model system causes mitochondrial dysfunction in the prefrontal cortex.
  4. Phosphorylation of T107 by CamKIIdelta Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1.
    Title: Phosphorylation of T107 by CamKIIδ Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1.
  5. RAGE-independent up-regulation of Glo1 in RAGE-KO mice might be as another explanation for, at least some, effects attributed to RAGE before.
    Title: Gene doubling increases glyoxalase 1 expression in RAGE knockout mice.
  6. The protein expression of GLO1 in basilar arteries from hypertensive mice was decreased, and GLO1 expression was negatively correlated with medial cross-sectional area and blood pressure in basilar arteries during hypertension.
    Title: Reduction of glyoxalase 1 (GLO1) aggravates cerebrovascular remodeling via promoting the proliferation of basilar smooth muscle cells in hypertension.
  7. Data suggest that GLO1 rescues bone marrow-derived progenitor cell dysfunction and facilitates wound healing in diabetic animals, at least partly through preventing methylglyoxal-induced impairment of IRE1alpha expression and activity.
    Title: Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes.
  8. The objective of the present study was to detect whether overexpression of methylglyoxal-metabolizing enzyme glyoxalase-1 (GLO1), which reduces reactive oxygen species in Diabetic Adipose-Derived Stem Cells, can restore their proangiogenic function in a streptozotocin-induced diabetic mice model of critical limb ischemia.
    Title: Glyoxalase-1 Overexpression Reverses Defective Proangiogenic Function of Diabetic Adipose-Derived Stem Cells in Streptozotocin-Induced Diabetic Mice Model of Critical Limb Ischemia.
  9. Transgenic mice overexpressing Glo1 on both FVB/NJ (FVB) or C57BL/6J (B6) backgrounds showed increased voluntary EtOH consumption compared to their wild-type littermates. Transgenic Glo1 knockdown mice on a B6 background showed decreased voluntary EtOH consumption. Genetic manipulations of Glo1 had no effect on sucrose, saccharin or water consumption.
    Title: Genetic and pharmacological manipulation of glyoxalase 1 regulates voluntary ethanol consumption in mice.
  10. the Glo1-methylglyoxal pathway integrates maternal and neural precursor cell metabolism to regulate neural development.
    Title: A Glo1-Methylglyoxal Pathway that Is Perturbed in Maternal Diabetes Regulates Embryonic and Adult Neural Stem Cell Pools in Murine Offspring.
Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Gene trapped (2) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lactoylglutathione lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lactoylglutathione lyase activity ISO
Inferred from Sequence Orthology
more info
  
enables lactoylglutathione lyase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in glutathione metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IC
Inferred by Curator
more info
 PubMed 
involved_in methylglyoxal metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
lactoylglutathione lyase
Names
S-D-lactoylglutathione methylglyoxal lyase
aldoketomutase
glx I
glyoxalase 1 complex
glyoxalase 1 regulatory
glyoxalase 1 structural
glyoxalase I
ketone-aldehyde mutase
methylglyoxalase
NP_001107032.1
NP_079650.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113560.1 → NP_001107032.1  lactoylglutathione lyase

    See identical proteins and their annotated locations for NP_001107032.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK049703, BG077218, BP769280, BY312309
    Consensus CDS
    CCDS28600.1
    UniProtKB/Swiss-Prot
    Q543L3, Q8R3T1, Q9CPU0
    UniProtKB/TrEMBL
    A5GZX3
    Related
    ENSMUSP00000126586.2, ENSMUST00000167624.2
    Conserved Domains (1) summary
    PLN03042
    Location:20 → 184
    PLN03042; Lactoylglutathione lyase; Provisional

  2. NM_025374.3 → NP_079650.3  lactoylglutathione lyase

    See identical proteins and their annotated locations for NP_079650.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK049703, BP769280, BY312309
    Consensus CDS
    CCDS28600.1
    UniProtKB/Swiss-Prot
    Q543L3, Q8R3T1, Q9CPU0
    UniProtKB/TrEMBL
    A5GZX3
    Related
    ENSMUSP00000158296.2, ENSMUST00000236335.2
    Conserved Domains (1) summary
    PLN03042
    Location:20 → 184
    PLN03042; Lactoylglutathione lyase; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    30811835..30831633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CPU0.3 GenPept UniProtKB/Swiss-Prot:Q9CPU0

Gene LinkOut

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