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RPS6KA6 ribosomal protein S6 kinase A6 [ Homo sapiens (human) ]

Gene ID: 27330, updated on 4-Jan-2025

Summary

Official Symbol
RPS6KA6provided by HGNC
Official Full Name
ribosomal protein S6 kinase A6provided by HGNC
Primary source
HGNC:HGNC:10435
See related
Ensembl:ENSG00000072133 MIM:300303; AllianceGenome:HGNC:10435
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RSK4; RSK-4; p90RSK6; PP90RSK4; S6K-alpha-6
Summary
This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010]
Expression
Broad expression in thyroid (RPKM 5.0), kidney (RPKM 2.6) and 17 other tissues See more
Orthologs
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Genomic context

See RPS6KA6 in Genome Data Viewer
Location:
Xq21.1
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (84058346..84188499, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (82493471..82624675, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (83313354..83443207, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene TERF1 pseudogene 4 Neighboring gene cylicin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:83239627-83240128 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:83240129-83240628 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:83298980-83299480 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:83301391-83301957 Neighboring gene microRNA 548i-4 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:83643706-83644905 Neighboring gene highly divergent homeobox

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables ribosomal protein S6 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in fibrillar center IDA
Inferred from Direct Assay
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ribosomal protein S6 kinase alpha-6
Names
90 kDa ribosomal protein S6 kinase 6
S6K-alpha 6
p90-RSK 6
ribosomal S6 kinase 4
ribosomal protein S6 kinase, 90kDa, polypeptide 6
NP_001317441.1
NP_055311.1
XP_011529219.1
XP_011529221.1
XP_011529222.1
XP_016884912.1
XP_016884913.1
XP_016884914.1
XP_047297952.1
XP_047297953.1
XP_054182821.1
XP_054182822.1
XP_054182823.1
XP_054182824.1
XP_054182825.1
XP_054182826.1
XP_054182827.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016340.1 RefSeqGene

    Range
    4737..134586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001330512.1NP_001317441.1  ribosomal protein S6 kinase alpha-6 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
    Source sequence(s)
    AL354653, AL389887, BC143648
    Consensus CDS
    CCDS83480.1
    UniProtKB/TrEMBL
    A0AAU7BN28, A0AAU7BN44
    Conserved Domains (2) summary
    cd05582
    Location:77391
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14177
    Location:421715
    STKc_RSK4_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6)
  2. NM_014496.5NP_055311.1  ribosomal protein S6 kinase alpha-6 isoform 2

    See identical proteins and their annotated locations for NP_055311.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (2) is the same length as isoform 1, but has a distinct N-terminus.
    Source sequence(s)
    AF184965, AK313240, AL354653, AL389887, BQ448025
    Consensus CDS
    CCDS14451.1
    UniProtKB/Swiss-Prot
    B2R854, B7ZL90, Q6FHX2, Q8WX28, Q9H4S6, Q9UK32
    UniProtKB/TrEMBL
    A0AAU7BN44
    Related
    ENSP00000262752.2, ENST00000262752.5
    Conserved Domains (2) summary
    cd05582
    Location:77391
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14177
    Location:421715
    STKc_RSK4_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    84058346..84188499 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441997.1XP_047297953.1  ribosomal protein S6 kinase alpha-6 isoform X3

    UniProtKB/TrEMBL
    A0AAU7BMN7, A0AAU7BN44
  2. XM_011530919.3XP_011529221.1  ribosomal protein S6 kinase alpha-6 isoform X4

    UniProtKB/TrEMBL
    A0AAU7BMR9, A0AAU7BMS3
    Conserved Domains (4) summary
    smart00220
    Location:1227
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:1288
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14177
    Location:318612
    STKc_RSK4_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6)
    pfam00069
    Location:323580
    Pkinase; Protein kinase domain
  3. XM_017029425.2XP_016884914.1  ribosomal protein S6 kinase alpha-6 isoform X1

    UniProtKB/TrEMBL
    A0AAU7BN44
  4. XM_047441996.1XP_047297952.1  ribosomal protein S6 kinase alpha-6 isoform X3

    UniProtKB/TrEMBL
    A0AAU7BMN7, A0AAU7BN44
  5. XM_011530917.3XP_011529219.1  ribosomal protein S6 kinase alpha-6 isoform X2

    See identical proteins and their annotated locations for XP_011529219.1

    UniProtKB/TrEMBL
    A0AAU7BN28, A0AAU7BN44
    Conserved Domains (2) summary
    cd05582
    Location:77391
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14177
    Location:421715
    STKc_RSK4_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6)
  6. XM_017029424.2XP_016884913.1  ribosomal protein S6 kinase alpha-6 isoform X1

    UniProtKB/TrEMBL
    A0AAU7BN44
  7. XM_017029423.2XP_016884912.1  ribosomal protein S6 kinase alpha-6 isoform X1

    UniProtKB/TrEMBL
    A0AAU7BN44
    Related
    ENSP00000483896.1, ENST00000620340.4
  8. XM_011530920.3XP_011529222.1  ribosomal protein S6 kinase alpha-6 isoform X5

    UniProtKB/TrEMBL
    A0AAU7BMT2, A0AAU7BN70
    Conserved Domains (4) summary
    smart00220
    Location:1209
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14177
    Location:300594
    STKc_RSK4_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6)
    pfam00069
    Location:305562
    Pkinase; Protein kinase domain
    cl21453
    Location:1270
    PKc_like; Protein Kinases, catalytic domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    82493471..82624675 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326851.1XP_054182826.1  ribosomal protein S6 kinase alpha-6 isoform X4

    UniProtKB/TrEMBL
    A0AAU7BMR9, A0AAU7BMS3
  2. XM_054326848.1XP_054182823.1  ribosomal protein S6 kinase alpha-6 isoform X1

    UniProtKB/TrEMBL
    A0AAU7BN44
  3. XM_054326850.1XP_054182825.1  ribosomal protein S6 kinase alpha-6 isoform X3

    UniProtKB/TrEMBL
    A0AAU7BMN7, A0AAU7BN44
  4. XM_054326849.1XP_054182824.1  ribosomal protein S6 kinase alpha-6 isoform X2

    UniProtKB/TrEMBL
    A0AAU7BN28, A0AAU7BN44
  5. XM_054326847.1XP_054182822.1  ribosomal protein S6 kinase alpha-6 isoform X1

    UniProtKB/TrEMBL
    A0AAU7BN44
  6. XM_054326846.1XP_054182821.1  ribosomal protein S6 kinase alpha-6 isoform X1

    UniProtKB/TrEMBL
    A0AAU7BN44
  7. XM_054326852.1XP_054182827.1  ribosomal protein S6 kinase alpha-6 isoform X5

    UniProtKB/TrEMBL
    A0AAU7BMT2, A0AAU7BN70