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RPS6KA6 ribosomal protein S6 kinase A6 [ Homo sapiens (human) ]

Gene ID: 27330, updated on 10-Jan-2021

Summary

Official Symbol
RPS6KA6provided by HGNC
Official Full Name
ribosomal protein S6 kinase A6provided by HGNC
Primary source
HGNC:HGNC:10435
See related
Ensembl:ENSG00000072133 MIM:300303
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RSK4; RSK-4; p90RSK6; PP90RSK4; S6K-alpha-6
Summary
This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010]
Expression
Broad expression in thyroid (RPKM 5.0), kidney (RPKM 2.6) and 17 other tissues See more
Orthologs
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Genomic context

See RPS6KA6 in Genome Data Viewer
Location:
Xq21.1
Exon count:
27
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (84058346..84188199, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (83313354..83442943, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene TERF1 pseudogene 4 Neighboring gene cylicin 1 Neighboring gene microRNA 548i-4 Neighboring gene highly divergent homeobox

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
ribosomal protein S6 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
fibrillar center IDA
Inferred from Direct Assay
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ribosomal protein S6 kinase alpha-6
Names
90 kDa ribosomal protein S6 kinase 6
S6K-alpha 6
p90-RSK 6
ribosomal S6 kinase 4
ribosomal protein S6 kinase, 90kDa, polypeptide 6
NP_001317441.1
NP_055311.1
XP_011529219.1
XP_011529221.1
XP_011529222.1
XP_016884912.1
XP_016884913.1
XP_016884914.1
XP_016884915.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016340.1 RefSeqGene

    Range
    4737..134586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001330512.1NP_001317441.1  ribosomal protein S6 kinase alpha-6 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
    Source sequence(s)
    AL354653, AL389887, BC143648
    Consensus CDS
    CCDS83480.1
    UniProtKB/Swiss-Prot
    Q9UK32
    Conserved Domains (2) summary
    cd05582
    Location:77391
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14177
    Location:421715
    STKc_RSK4_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6)
  2. NM_014496.5NP_055311.1  ribosomal protein S6 kinase alpha-6 isoform 2

    See identical proteins and their annotated locations for NP_055311.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (2) is the same length as isoform 1, but has a distinct N-terminus.
    Source sequence(s)
    AF184965, AK313240, AL354653, AL389887, BQ448025
    Consensus CDS
    CCDS14451.1
    UniProtKB/Swiss-Prot
    Q9UK32
    Related
    ENSP00000262752.2, ENST00000262752.5
    Conserved Domains (2) summary
    cd05582
    Location:77391
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14177
    Location:421715
    STKc_RSK4_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    84058346..84188199 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029423.2XP_016884912.1  ribosomal protein S6 kinase alpha-6 isoform X1

    Related
    ENSP00000483896.1, ENST00000620340.4
  2. XM_011530919.2XP_011529221.1  ribosomal protein S6 kinase alpha-6 isoform X3

    Conserved Domains (4) summary
    smart00220
    Location:1227
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:1288
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14177
    Location:318612
    STKc_RSK4_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6)
    pfam00069
    Location:323580
    Pkinase; Protein kinase domain
  3. XM_011530917.2XP_011529219.1  ribosomal protein S6 kinase alpha-6 isoform X2

    See identical proteins and their annotated locations for XP_011529219.1

    UniProtKB/Swiss-Prot
    Q9UK32
    Conserved Domains (2) summary
    cd05582
    Location:77391
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14177
    Location:421715
    STKc_RSK4_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6)
  4. XM_017029424.1XP_016884913.1  ribosomal protein S6 kinase alpha-6 isoform X1

  5. XM_017029425.1XP_016884914.1  ribosomal protein S6 kinase alpha-6 isoform X1

  6. XM_011530920.2XP_011529222.1  ribosomal protein S6 kinase alpha-6 isoform X4

    Conserved Domains (4) summary
    smart00220
    Location:1209
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14177
    Location:300594
    STKc_RSK4_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6)
    pfam00069
    Location:305562
    Pkinase; Protein kinase domain
    cl21453
    Location:1270
    PKc_like; Protein Kinases, catalytic domain
  7. XM_017029426.1XP_016884915.1  ribosomal protein S6 kinase alpha-6 isoform X5

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