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Rps6ka6 ribosomal protein S6 kinase polypeptide 6 [ Mus musculus (house mouse) ]

Gene ID: 67071, updated on 27-Nov-2024

Summary

Official Symbol
Rps6ka6provided by MGI
Official Full Name
ribosomal protein S6 kinase polypeptide 6provided by MGI
Primary source
MGI:MGI:1914321
See related
Ensembl:ENSMUSG00000025665 AllianceGenome:MGI:1914321
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RSK4; S6K-alpha-6; 2610524K04Rik
Summary
Predicted to enable ribosomal protein S6 kinase activity. Involved in negative regulation of ERK1 and ERK2 cascade; negative regulation of embryonic development; and negative regulation of mesoderm development. Is active in synapse. Is expressed in several structures, including axial skeleton thoracic region; genitourinary system; nervous system; nose; and respiratory system. Orthologous to human RPS6KA6 (ribosomal protein S6 kinase A6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in placenta adult (RPKM 15.3), CNS E11.5 (RPKM 4.6) and 7 other tissues See more
Orthologs
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Genomic context

See Rps6ka6 in Genome Data Viewer
Location:
X E1; X 48.2 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (110297534..110447794, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (111387837..111538097, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene developmental pluripotency associated 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47771 Neighboring gene STARR-seq mESC enhancer starr_47772 Neighboring gene nuclear encoded tRNA arginine 4 (anticodon CCT) Neighboring gene predicted gene 7340 Neighboring gene highly divergent homeobox

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables ribosomal protein S6 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ribosomal protein S6 kinase alpha-6
NP_001361636.2
NP_001385703.1
NP_080225.2
XP_006528463.1
XP_006528464.1
XP_006528465.1
XP_006528466.1
XP_011246008.1
XP_011246009.1
XP_030107348.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374707.3NP_001361636.2  ribosomal protein S6 kinase alpha-6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CR392009
    UniProtKB/TrEMBL
    A2CEE7
    Related
    ENSMUSP00000094073.5, ENSMUST00000096348.10
  2. NM_001398774.1NP_001385703.1  ribosomal protein S6 kinase alpha-6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    CR392009
    UniProtKB/TrEMBL
    E9PUP0
    Related
    ENSMUSP00000109055.4, ENSMUST00000113428.9
  3. NM_025949.3NP_080225.2  ribosomal protein S6 kinase alpha-6 isoform 1

    See identical proteins and their annotated locations for NP_080225.2

    Status: VALIDATED

    Source sequence(s)
    AK012150, AK049349, BC054113, BY096109, CR392009
    Consensus CDS
    CCDS30356.1
    UniProtKB/Swiss-Prot
    Q7TPS0, Q8BWZ2, Q9CUR6
    UniProtKB/TrEMBL
    B1B0X3, E9QK39
    Related
    ENSMUSP00000115975.3, ENSMUST00000123951.9
    Conserved Domains (2) summary
    cd05582
    Location:193507
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14091
    Location:542828
    STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    110297534..110447794 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247706.4XP_011246008.1  ribosomal protein S6 kinase alpha-6 isoform X4

    UniProtKB/Swiss-Prot
    Q7TPS0, Q8BWZ2, Q9CUR6
    Conserved Domains (2) summary
    cd05582
    Location:109423
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14091
    Location:458744
    STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases
  2. XM_006528403.4XP_006528466.1  ribosomal protein S6 kinase alpha-6 isoform X3

    UniProtKB/TrEMBL
    A2CEE5
    Conserved Domains (2) summary
    cd05582
    Location:172486
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14091
    Location:521807
    STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases
  3. XM_006528402.4XP_006528465.1  ribosomal protein S6 kinase alpha-6 isoform X2

    UniProtKB/Swiss-Prot
    Q7TPS0, Q8BWZ2, Q9CUR6
    Conserved Domains (2) summary
    cd05582
    Location:193507
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14091
    Location:542823
    STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases
  4. XM_006528401.5XP_006528464.1  ribosomal protein S6 kinase alpha-6 isoform X1

    See identical proteins and their annotated locations for XP_006528464.1

    UniProtKB/Swiss-Prot
    Q7TPS0, Q8BWZ2, Q9CUR6
    UniProtKB/TrEMBL
    B1B0X3, E9QK39
    Conserved Domains (2) summary
    cd05582
    Location:193507
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14091
    Location:542828
    STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases
  5. XM_006528400.5XP_006528463.1  ribosomal protein S6 kinase alpha-6 isoform X1

    See identical proteins and their annotated locations for XP_006528463.1

    UniProtKB/Swiss-Prot
    Q7TPS0, Q8BWZ2, Q9CUR6
    UniProtKB/TrEMBL
    B1B0X3, E9QK39
    Conserved Domains (2) summary
    cd05582
    Location:193507
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14091
    Location:542828
    STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases
  6. XM_011247707.4XP_011246009.1  ribosomal protein S6 kinase alpha-6 isoform X6

    UniProtKB/Swiss-Prot
    Q7TPS0, Q8BWZ2, Q9CUR6
    Conserved Domains (2) summary
    cd05582
    Location:65379
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14091
    Location:414700
    STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases
  7. XM_030251488.2XP_030107348.1  ribosomal protein S6 kinase alpha-6 isoform X5

    UniProtKB/Swiss-Prot
    Q7TPS0, Q8BWZ2, Q9CUR6
    Conserved Domains (2) summary
    cd05582
    Location:114428
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14091
    Location:463744
    STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases