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CHMP2A charged multivesicular body protein 2A [ Homo sapiens (human) ]

Gene ID: 27243, updated on 1-Mar-2024

Summary

Official Symbol
CHMP2Aprovided by HGNC
Official Full Name
charged multivesicular body protein 2Aprovided by HGNC
Primary source
HGNC:HGNC:30216
See related
Ensembl:ENSG00000130724 MIM:610893; AllianceGenome:HGNC:30216
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BC2; BC-2; VPS2; CHMP2; VPS2A
Summary
CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in colon (RPKM 34.2), kidney (RPKM 32.8) and 25 other tissues See more
Orthologs
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Genomic context

See CHMP2A in Genome Data Viewer
Location:
19q13.43
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (58551566..58555105, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61649242..61652782, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (59062933..59066472, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:59054606-59055110 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11091 Neighboring gene RNA, 7SL, cytoplasmic 525, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11092 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11093 Neighboring gene tripartite motif containing 28 Neighboring gene microRNA 6807 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15209 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15210 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59067095-59067778 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11094 Neighboring gene ubiquitin conjugating enzyme E2 M Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15211 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59070738-59071334 Neighboring gene MZF1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11096 Neighboring gene myeloid zinc finger 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59083407-59084268 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59084269-59085128

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of charged multivesicular body protein 2A (CHMP2A) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Three-dimensional superresolution microscopy and correlative electron microscopy demonstrate that the ESCRT proteins TSG101, CHMP2A, and CHMP4B co-cluster with membrane-localized HIV-1 Gag at assembly sites PubMed
gag ALIX, CHMP2A/B, CHMP4A/B, and VPS4A/B proteins are required for the budding of HIV-1 Gag and the HIV-1 infectivity PubMed
gag Released Gag VLPs contain TSG101 and CHMP4B, but reduced levels of CHMP2A relative to CHMP4B PubMed
gag Recruitment of CHMP2A and CHMP3 by CHMP4B to HIV-1 Gag puncta is observed in in-vitro membrane model PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatidylcholine binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ESCRT III complex disassembly NAS
Non-traceable Author Statement
more info
PubMed 
involved_in autophagosome maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endosome transport via multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in establishment of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in exit from mitosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in late endosome to lysosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in late endosome to vacuole transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in macroautophagy TAS
Traceable Author Statement
more info
PubMed 
involved_in membrane fission NAS
Non-traceable Author Statement
more info
PubMed 
involved_in membrane invagination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in midbody abscission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic metaphase chromosome alignment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multivesicular body assembly NAS
Non-traceable Author Statement
more info
PubMed 
involved_in multivesicular body assembly TAS
Traceable Author Statement
more info
PubMed 
involved_in multivesicular body sorting pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in multivesicular body-lysosome fusion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of centriole elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear membrane reassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleus organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in plasma membrane repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of exosomal secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein homooligomerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of centrosome duplication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vesicle fusion with vacuole NAS
Non-traceable Author Statement
more info
PubMed 
involved_in viral budding from plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in viral budding from plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in viral budding via host ESCRT complex IDA
Inferred from Direct Assay
more info
PubMed 
involved_in viral budding via host ESCRT complex IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in viral budding via host ESCRT complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in viral budding via host ESCRT complex TAS
Traceable Author Statement
more info
PubMed 
involved_in viral release from host cell IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in viral release from host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of ESCRT III complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ESCRT III complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ESCRT III complex TAS
Traceable Author Statement
more info
PubMed 
located_in amphisome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in autophagosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in kinetochore microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 
part_of membrane coat IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in multivesicular body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in multivesicular body membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
charged multivesicular body protein 2a
Names
VPS2 homolog A
chromatin modifying protein 2A
putative breast adenocarcinoma marker (32kD)
putative breast adenocarcinoma marker BC-2
vacuolar protein sorting-associated protein 2-1
vps2-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014453.4NP_055268.1  charged multivesicular body protein 2a

    See identical proteins and their annotated locations for NP_055268.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC002502, BP315111
    Consensus CDS
    CCDS12986.1
    UniProtKB/Swiss-Prot
    B2R4W6, O43633, Q3ZTT0
    Related
    ENSP00000310440.1, ENST00000312547.7
    Conserved Domains (1) summary
    pfam03357
    Location:17185
    Snf7
  2. NM_198426.3NP_940818.1  charged multivesicular body protein 2a

    See identical proteins and their annotated locations for NP_940818.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC016630, BC002502, CN305066
    Consensus CDS
    CCDS12986.1
    UniProtKB/Swiss-Prot
    B2R4W6, O43633, Q3ZTT0
    Related
    ENSP00000472680.1, ENST00000601220.5
    Conserved Domains (1) summary
    pfam03357
    Location:17185
    Snf7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    58551566..58555105 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258746.3XP_005258803.1  charged multivesicular body protein 2a isoform X1

    See identical proteins and their annotated locations for XP_005258803.1

    UniProtKB/TrEMBL
    M0R1T5
    Related
    ENSP00000472097.2, ENST00000600006.6
    Conserved Domains (1) summary
    pfam03357
    Location:17181
    Snf7; Snf7
  2. XM_005258747.4XP_005258804.1  charged multivesicular body protein 2a isoform X1

    See identical proteins and their annotated locations for XP_005258804.1

    UniProtKB/TrEMBL
    M0R1T5
    Conserved Domains (1) summary
    pfam03357
    Location:17181
    Snf7; Snf7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    61649242..61652782 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320574.1XP_054176549.1  charged multivesicular body protein 2a isoform X1

    UniProtKB/TrEMBL
    M0R1T5
  2. XM_054320575.1XP_054176550.1  charged multivesicular body protein 2a isoform X1

    UniProtKB/TrEMBL
    M0R1T5