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SERP1 stress associated endoplasmic reticulum protein 1 [ Homo sapiens (human) ]

Gene ID: 27230, updated on 5-Aug-2022

Summary

Official Symbol
SERP1provided by HGNC
Official Full Name
stress associated endoplasmic reticulum protein 1provided by HGNC
Primary source
HGNC:HGNC:10759
See related
Ensembl:ENSG00000120742 MIM:617674; AllianceGenome:HGNC:10759
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAMP4
Summary
Predicted to be involved in endoplasmic reticulum unfolded protein response and protein glycosylation. Predicted to act upstream of or within several processes, including multicellular organism aging; positive regulation of organ growth; and positive regulation of peptide hormone secretion. Located in cytoplasmic microtubule. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 68.2), prostate (RPKM 46.3) and 25 other tissues See more
Orthologs
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Genomic context

See SERP1 in Genome Data Viewer
Location:
3q25.1
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (150541998..150546496, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (153293254..153297751, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (150259785..150264283, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 6181 Neighboring gene TSC22 domain family member 2 Neighboring gene uncharacterized LOC124900547 Neighboring gene eukaryotic translation initiation factor 2A Neighboring gene selenoprotein T Neighboring gene Sin3A associated protein 30kDa pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat modulates SERP1 expression in neuron cells PubMed
Vpr vpr The RNA and protein levels of stress-associated endoplasmic reticulum protein 1 (SERP1) decreases in Vpr-treated human neurons compared to the untreated control PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117327, MGC133321, MGC133322

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism aging IEA
Inferred from Electronic Annotation
more info
 
involved_in muscle organ morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in plasma membrane organization TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of growth hormone secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of organ growth IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein modification process TAS
Traceable Author Statement
more info
PubMed 
involved_in skeletal system development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in ribosome TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
stress-associated endoplasmic reticulum protein 1
Names
ribosome associated membrane protein 4
ribosome-attached membrane protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014445.4NP_055260.1  stress-associated endoplasmic reticulum protein 1

    See identical proteins and their annotated locations for NP_055260.1

    Status: VALIDATED

    Source sequence(s)
    AA890577, AC107426, BC108314, DB022941
    Consensus CDS
    CCDS3150.1
    UniProtKB/Swiss-Prot
    D3DNI6, Q9Y6X1
    Related
    ENSP00000239944.2, ENST00000239944.7
    Conserved Domains (1) summary
    pfam06624
    Location:259
    RAMP4; Ribosome associated membrane protein RAMP4

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    150541998..150546496 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    153293254..153297751 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)