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GPR78 G protein-coupled receptor 78 [ Homo sapiens (human) ]

Gene ID: 27201, updated on 5-Jan-2022

Summary

Official Symbol
GPR78provided by HGNC
Official Full Name
G protein-coupled receptor 78provided by HGNC
Primary source
HGNC:HGNC:4528
See related
Ensembl:ENSG00000155269 MIM:606921
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene belongs to the G protein-coupled receptor family, which contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. This is an orphan receptor, which displays significant level of constitutive activity. Association analysis shows preliminary evidence for the involvement of this gene in susceptibility to bipolar affective disorder and schizophrenia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]
Expression
Biased expression in placenta (RPKM 2.0), esophagus (RPKM 0.8) and 1 other tissue See more
Orthologs
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Genomic context

See GPR78 in Genome Data Viewer
Location:
4p16.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (8580392..8590023)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (8582119..8591750)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene acyl-CoA oxidase 3, pristanoyl Neighboring gene uncharacterized LOC105374376 Neighboring gene tRNA methyltransferase 44 homolog Neighboring gene Sharpr-MPRA regulatory region 4448 Neighboring gene carboxypeptidase Z Neighboring gene uncharacterized LOC101928532

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: CPZ

Homology

Clone Names

  • FLJ98800

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
G-protein coupled receptor 78

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080819.5NP_543009.2  G-protein coupled receptor 78

    See identical proteins and their annotated locations for NP_543009.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein.
    Source sequence(s)
    AC105345, AK128807, BC057778, BE645298
    Consensus CDS
    CCDS3403.1
    UniProtKB/Swiss-Prot
    Q96P69
    UniProtKB/TrEMBL
    B2R7M4
    Related
    ENSP00000371927.4, ENST00000382487.5
    Conserved Domains (1) summary
    pfam00001
    Location:23294
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RNA

  1. NR_045511.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AC105345, AK307281, BE645298

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    8580392..8590023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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