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CPZ carboxypeptidase Z [ Homo sapiens (human) ]

Gene ID: 8532, updated on 1-Jun-2020

Summary

Official Symbol
CPZprovided by HGNC
Official Full Name
carboxypeptidase Zprovided by HGNC
Primary source
HGNC:HGNC:2333
See related
Ensembl:ENSG00000109625 MIM:603105
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the metallocarboxypeptidase family. This enzyme displays carboxypeptidase activity towards substrates with basic C-terminal residues. It is most active at neutral pH and is inhibited by active site-directed inhibitors of metallocarboxypeptidases. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Biased expression in ovary (RPKM 47.9), placenta (RPKM 26.8) and 8 other tissues See more
Orthologs

Genomic context

See CPZ in Genome Data Viewer
Location:
4p16.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (8592660..8619761)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (8594387..8621488)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase 44 homolog Neighboring gene Sharpr-MPRA regulatory region 4448 Neighboring gene G protein-coupled receptor 78 Neighboring gene uncharacterized LOC101928532 Neighboring gene uncharacterized LOC105374474 Neighboring gene H6 family homeobox 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: GPR78

Homology

Clone Names

  • MGC99682

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
peptide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
carboxypeptidase Z
Names
VEZT/CPZ fusion
epididymis secretory sperm binding protein
metallocarboxypeptidase Z

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014447.3NP_001014447.2  carboxypeptidase Z isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    AC105345, KF495771, KF510872
    Consensus CDS
    CCDS33953.1
    Related
    ENSP00000354255.4, ENST00000360986.9
    Conserved Domains (3) summary
    cd07447
    Location:40167
    CRD_Carboxypeptidase_Z; Cysteine-rich domain of carboxypeptidase Z, a member of the carboxypeptidase E family
    cd03867
    Location:187501
    M14_CPZ; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase Z subgroup
    cd11308
    Location:505581
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
  2. NM_001014448.2NP_001014448.1  carboxypeptidase Z isoform 3

    See identical proteins and their annotated locations for NP_001014448.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses two different splice sites, which results in translation initiation at a downstream start codon, compared to variant 1. The resulting protein (isoform 3) is shorter and has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AW139378, BC006393, BF993977, DA050438, DA698835, DA704214, U83411
    Consensus CDS
    CCDS43212.1
    UniProtKB/Swiss-Prot
    Q66K79
    Related
    ENSP00000371920.2, ENST00000382480.6
    Conserved Domains (3) summary
    cd03867
    Location:50364
    M14_CPZ; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase Z subgroup
    cd11308
    Location:368444
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cl02447
    Location:130
    CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
  3. NM_003652.3NP_003643.2  carboxypeptidase Z isoform 2 precursor

    See identical proteins and their annotated locations for NP_003643.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2) that has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AW139378, BX338482, CV026874, DA704214, U83411
    Consensus CDS
    CCDS3404.1
    UniProtKB/Swiss-Prot
    Q66K79
    Related
    ENSP00000315074.6, ENST00000315782.6
    Conserved Domains (3) summary
    cd07447
    Location:30156
    CRD_Carboxypeptidase_Z; Cysteine-rich domain of carboxypeptidase Z, a member of the carboxypeptidase E family
    cd03867
    Location:176490
    M14_CPZ; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase Z subgroup
    cd11308
    Location:494570
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    8592660..8619761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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