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PELP1 proline, glutamate and leucine rich protein 1 [ Homo sapiens (human) ]

Gene ID: 27043, updated on 11-Sep-2019

Summary

Official Symbol
PELP1provided by HGNC
Official Full Name
proline, glutamate and leucine rich protein 1provided by HGNC
Primary source
HGNC:HGNC:30134
See related
Ensembl:ENSG00000141456 MIM:609455
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MNAR; P160
Summary
This gene encodes a transcription factor which coactivates transcription of estrogen receptor responsive genes and corepresses genes activated by other hormone receptors or sequence-specific transcription factors. Expression of this gene is regulated by both members of the estrogen receptor family. This gene may be involved in the progression of several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Expression
Ubiquitous expression in testis (RPKM 17.1), brain (RPKM 10.6) and 25 other tissues See more
Orthologs

Genomic context

See PELP1 in Genome Data Viewer
Location:
17p13.2
Exon count:
19
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (4669774..4704137, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4574679..4607712, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene arachidonate 15-lipoxygenase Neighboring gene uncharacterized LOC105371499 Neighboring gene uncharacterized LOC101559451 Neighboring gene ribosomal protein S12 pseudogene 29 Neighboring gene arrestin beta 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of proline, glutamate and leucine rich protein 1 (PELP1) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to estrogen stimulus IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
rRNA processing TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
MLL1 complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
transcriptionally active chromatin IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
proline-, glutamic acid- and leucine-rich protein 1
Names
modulator of non-genomic activity of estrogen receptor
proline and glutamic acid rich nuclear protein
transcription factor HMX3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278241.2NP_001265170.1  proline-, glutamic acid- and leucine-rich protein 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR, uses a downstream in-frame start codon, and lacks an alternate in-frame segment in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC091153, AK293838, AK299084, BC010457, DC417876
    Consensus CDS
    CCDS62038.1
    UniProtKB/Swiss-Prot
    Q8IZL8
    UniProtKB/TrEMBL
    B4DEX7, B4DR36, E7EV54
    Related
    ENSP00000416231.2, ENST00000436683.6
    Conserved Domains (2) summary
    pfam08166
    Location:276342
    NUC202; NUC202 domain
    pfam08167
    Location:285
    RIX1; rRNA processing/ribosome biogenesis
  2. NM_014389.3NP_055204.4  proline-, glutamic acid- and leucine-rich protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC091153, AI927300, BC010457, BC069058, DC417876
    Consensus CDS
    CCDS58503.2
    Related
    ENSP00000460300.2, ENST00000572293.6

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    4669774..4704137 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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