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Pelp1 proline, glutamic acid and leucine rich protein 1 [ Mus musculus (house mouse) ]

Gene ID: 75273, updated on 9-May-2024

Summary

Official Symbol
Pelp1provided by MGI
Official Full Name
proline, glutamic acid and leucine rich protein 1provided by MGI
Primary source
MGI:MGI:1922523
See related
Ensembl:ENSMUSG00000018921 AllianceGenome:MGI:1922523
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MNAR; 4930563C04Rik
Summary
Predicted to enable several functions, including ATPase binding activity; SUMO binding activity; and protein N-terminus binding activity. Predicted to be involved in cellular response to estrogen stimulus and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleolus; nucleoplasm; and transcriptionally active chromatin. Predicted to be part of MLL1 complex. Is expressed in cerebral cortex; hypothalamus; and midbrain. Orthologous to human PELP1 (proline, glutamate and leucine rich protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 16.4), ovary adult (RPKM 15.2) and 28 other tissues See more
Orthologs
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Genomic context

See Pelp1 in Genome Data Viewer
Location:
11 B3; 11 42.99 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70283709..70300862, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70392881..70410031, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene arachidonate lipoxygenase, epidermal Neighboring gene arachidonate 15-lipoxygenase Neighboring gene STARR-seq mESC enhancer starr_29874 Neighboring gene FGFR1 oncogene partner 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_29875 Neighboring gene STARR-seq mESC enhancer starr_29876 Neighboring gene predicted gene 12313 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 8 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SUMO binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to estrogen stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of euchromatin ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
proline-, glutamic acid- and leucine-rich protein 1
Names
modulator of non-genomic activity of estrogen receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029231.5NP_083507.3  proline-, glutamic acid- and leucine-rich protein 1

    See identical proteins and their annotated locations for NP_083507.3

    Status: VALIDATED

    Source sequence(s)
    AL596096
    Consensus CDS
    CCDS24945.1
    UniProtKB/Swiss-Prot
    Q5F2E2, Q6PEM0, Q91YM9, Q9DBD5
    UniProtKB/TrEMBL
    A0A158SIT8
    Related
    ENSMUSP00000019065.4, ENSMUST00000019065.10
    Conserved Domains (2) summary
    pfam08166
    Location:424475
    NUC202; NUC202 domain
    pfam08167
    Location:83232
    RIX1; rRNA processing/ribosome biogenesis

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    70283709..70300862 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)