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Lrrc36 leucine rich repeat containing 36 [ Mus musculus (house mouse) ]

Gene ID: 270091, updated on 2-Nov-2024

Summary

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Official Symbol
Lrrc36provided by MGI
Official Full Name
leucine rich repeat containing 36provided by MGI
Primary source
MGI:MGI:2448585
See related
Ensembl:ENSMUSG00000054320 AllianceGenome:MGI:2448585
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Orthologous to human LRRC36 (leucine rich repeat containing 36). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 27.0), lung adult (RPKM 2.4) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Lrrc36 in Genome Data Viewer
Location:
8 D3; 8 53.04 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106140230..106190718)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105413598..105464086)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:107871965-107872074 Neighboring gene solute carrier family 9 (sodium/hydrogen exchanger), member 5 Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 4 Neighboring gene potassium channel tetramerisation domain containing 19 Neighboring gene tubulin polymerization-promoting protein family member 3 Neighboring gene zinc finger, DHHC domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The centriolar satellite proteins Cep72 and Cep290 interact and are required for recruitment of BBS proteins to the cilium. Stowe TR, et al. Mol Biol Cell, 2012 Sep. PMID 22767577, Free PMC Article
  2. Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Miyata H, et al. Proc Natl Acad Sci U S A, 2016 Jul 12. PMID 27357688, Free PMC Article
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033371.3 → NP_001028543.1  leucine-rich repeat-containing protein 36 isoform 3

    See identical proteins and their annotated locations for NP_001028543.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus and lacks a 2 residue internal segment, compared to isoform 1.
    Source sequence(s)
    AK133042, BC036564
    Consensus CDS
    CCDS22601.1
    UniProtKB/Swiss-Prot
    Q3V0M2
    Related
    ENSMUSP00000066345.7, ENSMUST00000067305.8

  2. NM_001170788.1 → NP_001164259.1  leucine-rich repeat-containing protein 36 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC090480, BC036564, BC172120, BY084860
    Consensus CDS
    CCDS52658.1
    UniProtKB/TrEMBL
    A0A1L1SRB0, F8WI85
    Related
    ENSMUSP00000104979.3, ENSMUST00000109355.9
    Conserved Domains (3) summary
    cd00116
    Location:42 → 107
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:26 → 51
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:26 → 84
    LRR_8; Leucine rich repeat

  3. NM_001170789.1 → NP_001164260.1  leucine-rich repeat-containing protein 36 isoform 2

    See identical proteins and their annotated locations for NP_001164260.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK133042, BC036564, BC172120
    UniProtKB/TrEMBL
    B7ZWL7

  4. NM_001402748.1 → NP_001389677.1  leucine-rich repeat-containing protein 36 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC090480

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    106140230..106190718
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531057.3 → XP_006531120.1  leucine-rich repeat-containing protein 36 isoform X3

    UniProtKB/TrEMBL
    A0A1L1SRB0
    Conserved Domains (2) summary
    sd00031
    Location:26 → 51
    LRR_1; leucine-rich repeat [structural motif]
    pfam14580
    Location:44 → 148
    LRR_9; Leucine-rich repeat

  2. XM_006531055.3 → XP_006531118.1  leucine-rich repeat-containing protein 36 isoform X1

    See identical proteins and their annotated locations for XP_006531118.1

    UniProtKB/Swiss-Prot
    B2RX53, Q3V0M2
    UniProtKB/TrEMBL
    A0A1L1SRB0
    Related
    ENSMUSP00000150103.2, ENSMUST00000213547.2
    Conserved Domains (2) summary
    sd00031
    Location:26 → 51
    LRR_1; leucine-rich repeat [structural motif]
    pfam14580
    Location:44 → 148
    LRR_9; Leucine-rich repeat

  3. XM_006531056.3 → XP_006531119.1  leucine-rich repeat-containing protein 36 isoform X2

    UniProtKB/TrEMBL
    A0A1L1SRB0
    Conserved Domains (2) summary
    sd00031
    Location:26 → 51
    LRR_1; leucine-rich repeat [structural motif]
    pfam14580
    Location:44 → 148
    LRR_9; Leucine-rich repeat

  4. XM_036154082.1 → XP_036009975.1  leucine-rich repeat-containing protein 36 isoform X5

    Conserved Domains (2) summary
    sd00031
    Location:26 → 51
    LRR_1; leucine-rich repeat [structural motif]
    cd21340
    Location:50 → 141
    PPP1R42; protein phosphatase 1 regulatory subunit 42

RNA

  1. XR_387748.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3V0M2.2 GenPept UniProtKB/Swiss-Prot:Q3V0M2

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