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LRRC36 leucine rich repeat containing 36 [ Homo sapiens (human) ]

Gene ID: 55282, updated on 9-Jun-2025
Official Symbol
LRRC36provided by HGNC
Official Full Name
leucine rich repeat containing 36provided by HGNC
Primary source
HGNC:HGNC:25615
See related
Ensembl:ENSG00000159708 AllianceGenome:HGNC:25615
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RORBP70; XLHSRF2
Expression
Biased expression in testis (RPKM 11.4), lung (RPKM 7.2) and 1 other tissue See more
Orthologs
mouse all
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See LRRC36 in Genome Data Viewer
Location:
16q22.1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67326815..67385204)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (73121113..73179975)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67360718..67419107)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903701 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7600 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67313287-67313468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67318282-67319022 Neighboring gene pleckstrin homology and RhoGEF domain containing G4 Neighboring gene potassium channel tetramerization domain containing 19 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10963 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10964 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7602 Neighboring gene RN7SK pseudogene 118 Neighboring gene RNA, U1 small nuclear 123, pseudogene Neighboring gene tubulin polymerization promoting protein family member 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67439721-67440606 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67440607-67441493 Neighboring gene zDHHC palmitoyltransferase 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67441494-67442379 Neighboring gene uncharacterized LOC124903702 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67450269-67450926

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. Suzuki Y, et al. Genome Res, 2004 Sep. PMID 15342556, Free PMC Article
  2. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
  3. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  5. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ11004

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
leucine-rich repeat-containing protein 36
Names
ROR gamma binding protein 70
heat shock regulated 2

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161575.2 → NP_001155047.1  leucine-rich repeat-containing protein 36 isoform 2

    See identical proteins and their annotated locations for NP_001155047.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK297329, AY313780, BC018031, BP294008
    Consensus CDS
    CCDS58474.1
    UniProtKB/Swiss-Prot
    Q1X8D7
    UniProtKB/TrEMBL
    B7Z4G3
    Related
    ENSP00000455103.1, ENST00000563189.5
    Conserved Domains (1) summary
    pfam03962
    Location:484 → 559
    Mnd1; Mnd1 family

  2. NM_018296.6 → NP_060766.5  leucine-rich repeat-containing protein 36 isoform 1

    See identical proteins and their annotated locations for NP_060766.5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC009061, BC018031, BC026156
    Consensus CDS
    CCDS32467.1
    UniProtKB/Swiss-Prot
    A4FTV6, A6NDE9, A8K8E6, B7Z7B3, Q1X8D7, Q7Z5K5
    Related
    ENSP00000329943.6, ENST00000329956.11
    Conserved Domains (3) summary
    sd00031
    Location:26 → 51
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:50 → 91
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:26 → 84
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    67326815..67385204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256025.3 → XP_005256082.1  leucine-rich repeat-containing protein 36 isoform X2

    Conserved Domains (3) summary
    sd00031
    Location:26 → 51
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:50 → 91
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:26 → 84
    LRR_8; Leucine rich repeat

  2. XM_005256027.3 → XP_005256084.1  leucine-rich repeat-containing protein 36 isoform X5

    See identical proteins and their annotated locations for XP_005256084.1

    Conserved Domains (3) summary
    sd00031
    Location:26 → 51
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:50 → 91
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:26 → 84
    LRR_8; Leucine rich repeat

  3. XM_005256026.3 → XP_005256083.1  leucine-rich repeat-containing protein 36 isoform X3

    Conserved Domains (3) summary
    sd00031
    Location:26 → 51
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:50 → 91
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:26 → 84
    LRR_8; Leucine rich repeat

  4. XM_017023401.2 → XP_016878890.1  leucine-rich repeat-containing protein 36 isoform X13

  5. XM_011523203.2 → XP_011521505.1  leucine-rich repeat-containing protein 36 isoform X9

    Conserved Domains (4) summary
    sd00031
    Location:26 → 51
    LRR_1; leucine-rich repeat [structural motif]
    cl11869
    Location:132 → 250
    Csc2_I-D; CRISPR/Cas system-associated protein Csc2
    pfam12799
    Location:50 → 91
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:26 → 84
    LRR_8; Leucine rich repeat

  6. XM_017023402.2 → XP_016878891.1  leucine-rich repeat-containing protein 36 isoform X14

  7. XM_005256028.2 → XP_005256085.1  leucine-rich repeat-containing protein 36 isoform X7

    See identical proteins and their annotated locations for XP_005256085.1

    Conserved Domains (1) summary
    pfam03962
    Location:437 → 512
    Mnd1; Mnd1 family

  8. XM_011523202.3 → XP_011521504.1  leucine-rich repeat-containing protein 36 isoform X8

    Conserved Domains (1) summary
    pfam03962
    Location:436 → 511
    Mnd1; Mnd1 family

  9. XM_047434329.1 → XP_047290285.1  leucine-rich repeat-containing protein 36 isoform X4

  10. XM_017023400.3 → XP_016878889.1  leucine-rich repeat-containing protein 36 isoform X1

    Conserved Domains (3) summary
    sd00031
    Location:26 → 51
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:50 → 91
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:26 → 84
    LRR_8; Leucine rich repeat

  11. XM_011523200.2 → XP_011521502.1  leucine-rich repeat-containing protein 36 isoform X6

    See identical proteins and their annotated locations for XP_011521502.1

    Conserved Domains (3) summary
    sd00031
    Location:26 → 51
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:50 → 91
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:26 → 84
    LRR_8; Leucine rich repeat

  12. XM_047434333.1 → XP_047290289.1  leucine-rich repeat-containing protein 36 isoform X12

  13. XM_011523206.4 → XP_011521508.1  leucine-rich repeat-containing protein 36 isoform X11

    Conserved Domains (3) summary
    sd00031
    Location:26 → 51
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:50 → 91
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:26 → 84
    LRR_8; Leucine rich repeat

  14. XM_047434332.1 → XP_047290288.1  leucine-rich repeat-containing protein 36 isoform X10

  15. XM_047434330.1 → XP_047290286.1  leucine-rich repeat-containing protein 36 isoform X10

  16. XM_024450338.2 → XP_024306106.1  leucine-rich repeat-containing protein 36 isoform X10

    Conserved Domains (1) summary
    cl27210
    Location:363 → 438
    Mnd1; Mnd1 family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    73121113..73179975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054380656.1 → XP_054236631.1  leucine-rich repeat-containing protein 36 isoform X2

  2. XM_054313397.1 → XP_054169372.1  leucine-rich repeat-containing protein 36 isoform X5

  3. XM_054313395.1 → XP_054169370.1  leucine-rich repeat-containing protein 36 isoform X3

  4. XM_054313407.1 → XP_054169382.1  leucine-rich repeat-containing protein 36 isoform X13

  5. XM_054313401.1 → XP_054169376.1  leucine-rich repeat-containing protein 36 isoform X9

  6. XM_054313408.1 → XP_054169383.1  leucine-rich repeat-containing protein 36 isoform X14

  7. XM_054313399.1 → XP_054169374.1  leucine-rich repeat-containing protein 36 isoform X7

  8. XM_054313400.1 → XP_054169375.1  leucine-rich repeat-containing protein 36 isoform X8

  9. XM_054313396.1 → XP_054169371.1  leucine-rich repeat-containing protein 36 isoform X4

  10. XM_054380655.1 → XP_054236630.1  leucine-rich repeat-containing protein 36 isoform X1

  11. XM_054313398.1 → XP_054169373.1  leucine-rich repeat-containing protein 36 isoform X6

  12. XM_054313406.1 → XP_054169381.1  leucine-rich repeat-containing protein 36 isoform X12

  13. XM_054313405.1 → XP_054169380.1  leucine-rich repeat-containing protein 36 isoform X11

  14. XM_054313403.1 → XP_054169378.1  leucine-rich repeat-containing protein 36 isoform X10

  15. XM_054313402.1 → XP_054169377.1  leucine-rich repeat-containing protein 36 isoform X10

  16. XM_054313404.1 → XP_054169379.1  leucine-rich repeat-containing protein 36 isoform X10

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1X8D7.2 GenPept UniProtKB/Swiss-Prot:Q1X8D7

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