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DNAJC2 DnaJ heat shock protein family (Hsp40) member C2 [ Homo sapiens (human) ]

Gene ID: 27000, updated on 5-Jul-2020

Summary

Official Symbol
DNAJC2provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member C2provided by HGNC
Primary source
HGNC:HGNC:13192
See related
Ensembl:ENSG00000105821 MIM:605502
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZRF1; ZUO1; MPP11; MPHOSPH11
Summary
This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 19.0), testis (RPKM 17.8) and 25 other tissues See more
Orthologs

Genomic context

See DNAJC2 in Genome Data Viewer
Location:
7q22.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (103312289..103344873, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (102952921..102985320, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375434 Neighboring gene ribosomal protein L23a pseudogene 95 Neighboring gene DPY19L2 pseudogene 2 Neighboring gene S100A11 pseudogene 1 Neighboring gene peptidase, mitochondrial processing subunit beta Neighboring gene ribosomal protein S29 pseudogene 16 Neighboring gene solute carrier family 26 member 5 Neighboring gene proteasome 26S subunit, ATPase 2 Neighboring gene uncharacterized LOC101927870

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
Hsp70 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
RNA binding HDA PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
histone binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin modification-dependent histone binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
'de novo' cotranslational protein folding TAS
Traceable Author Statement
more info
PubMed 
DNA replication IEA
Inferred from Electronic Annotation
more info
 
chromatin organization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cellular response to heat TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dnaJ homolog subfamily C member 2
Names
DnaJ (Hsp40) homolog, subfamily C, member 2
M-phase phosphoprotein 11
zuotin-related factor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001129887.2NP_001123359.1  dnaJ homolog subfamily C member 2 isoform 2

    See identical proteins and their annotated locations for NP_001123359.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC004668, AI140595, X98260
    Consensus CDS
    CCDS47679.1
    UniProtKB/Swiss-Prot
    Q99543
    Related
    ENSP00000249270.7, ENST00000249270.11
    Conserved Domains (4) summary
    smart00717
    Location:498549
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    COG5269
    Location:75361
    ZUO1; Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones]
    cd00167
    Location:500547
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam00226
    Location:88158
    DnaJ; DnaJ domain
  2. NM_001362667.1NP_001349596.1  dnaJ homolog subfamily C member 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in its 5' UTR, resulting in the use of a downstream start codon relative to variant 1. The encoded protein (isoform 3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AI140595, BC000859, BC056682, BX279826, DA272314, DA691752
    Conserved Domains (3) summary
    cd00167
    Location:479526
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam16717
    Location:270346
    RAC_head; Ribosome-associated complex head domain
    cl28246
    Location:1294
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
  3. NM_001362668.1NP_001349597.1  dnaJ homolog subfamily C member 2 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in its 5' UTR, resulting in the use of a downstream start codon relative to variant 1. The encoded protein (isoform 3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AI140595, BC000859, BC056682, BX279826, DA272314, DA691752
    Conserved Domains (3) summary
    cd00167
    Location:407454
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam16717
    Location:198274
    RAC_head; Ribosome-associated complex head domain
    cl28246
    Location:1222
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
  4. NM_014377.3NP_055192.1  dnaJ homolog subfamily C member 2 isoform 1

    See identical proteins and their annotated locations for NP_055192.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AI140595, AI621015, BC000859, BC012376, DA272314, DA691752, X98260
    Consensus CDS
    CCDS43628.1
    UniProtKB/Swiss-Prot
    Q99543
    Related
    ENSP00000368565.3, ENST00000379263.8
    Conserved Domains (5) summary
    smart00717
    Location:551602
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    COG5269
    Location:75368
    ZUO1; Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones]
    cd00167
    Location:553600
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam00226
    Location:88158
    DnaJ; DnaJ domain
    pfam16717
    Location:349420
    RAC_head; Ribosome-associated complex head domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    103312289..103344873 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011968.2XP_016867457.1  dnaJ homolog subfamily C member 2 isoform X3

    Conserved Domains (3) summary
    smart00717
    Location:348399
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:350397
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam16717
    Location:146217
    RAC_head; Ribosome-associated complex head domain
  2. XM_011516029.2XP_011514331.1  dnaJ homolog subfamily C member 2 isoform X2

    See identical proteins and their annotated locations for XP_011514331.1

    Related
    ENST00000475065.5
    Conserved Domains (3) summary
    cd00167
    Location:407454
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam16717
    Location:198274
    RAC_head; Ribosome-associated complex head domain
    cl28246
    Location:1222
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
  3. XM_011516030.2XP_011514332.1  dnaJ homolog subfamily C member 2 isoform X3

    Conserved Domains (3) summary
    smart00717
    Location:348399
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:350397
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam16717
    Location:146217
    RAC_head; Ribosome-associated complex head domain
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