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Dnajc2 DnaJ heat shock protein family (Hsp40) member C2 [ Mus musculus (house mouse) ]

Gene ID: 22791, updated on 6-Jun-2024

Summary

Official Symbol
Dnajc2provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member C2provided by MGI
Primary source
MGI:MGI:99470
See related
Ensembl:ENSMUSG00000029014 AllianceGenome:MGI:99470
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zrf1; Zrf2; MIDA1
Summary
Predicted to enable several functions, including Hsp70 protein binding activity; ribosome binding activity; and ubiquitin modification-dependent histone binding activity. Acts upstream of or within DNA replication and negative regulation of DNA biosynthetic process. Predicted to be located in cytoplasm; nuclear membrane; and nucleolus. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; blastocyst; brain; hemolymphoid system gland; and reproductive system. Orthologous to human DNAJC2 (DnaJ heat shock protein family (Hsp40) member C2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 20.3), CNS E11.5 (RPKM 19.1) and 28 other tissues See more
Orthologs
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Genomic context

See Dnajc2 in Genome Data Viewer
Location:
5 A3; 5 9.97 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (21962279..21990183, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (21757266..21785264, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1463 Neighboring gene STARR-positive B cell enhancer ABC_E11721 Neighboring gene predicted gene, 54323 Neighboring gene STARR-seq mESC enhancer starr_12576 Neighboring gene peptidase (mitochondrial processing) beta Neighboring gene predicted gene 15715 Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase 2 Neighboring gene solute carrier family 26, member 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Related articles in PubMed

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4)  1 citation
  • Gene trapped (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Hsp70 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-modified histone reader activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dnaJ homolog subfamily C member 2
Names
DnaJ (Hsp40) homolog, subfamily C, member 2
Id associate 1
zuotin related factor 2
zuotin-related factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417606.1NP_001404535.1  dnaJ homolog subfamily C member 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125313
    UniProtKB/TrEMBL
    E9Q9H2, E9Q9H3
    Related
    ENSMUSP00000110849.2, ENSMUST00000115195.8
  2. NM_001417607.1NP_001404536.1  dnaJ homolog subfamily C member 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC125313
    UniProtKB/TrEMBL
    Q3TRX6
    Related
    ENSMUST00000147987.2
  3. NM_001417608.1NP_001404537.1  dnaJ homolog subfamily C member 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC125313
  4. NM_009584.5NP_033610.1  dnaJ homolog subfamily C member 2 isoform 1

    See identical proteins and their annotated locations for NP_033610.1

    Status: VALIDATED

    Source sequence(s)
    AC125313
    Consensus CDS
    CCDS19107.1
    UniProtKB/Swiss-Prot
    P54103, Q61866
    UniProtKB/TrEMBL
    E9Q9H3
    Related
    ENSMUSP00000030771.6, ENSMUST00000030771.12
    Conserved Domains (5) summary
    smart00717
    Location:552602
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    COG5269
    Location:75368
    ZUO1; Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones]
    cd00167
    Location:553600
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam00226
    Location:88158
    DnaJ; DnaJ domain
    pfam16717
    Location:349420
    RAC_head; Ribosome-associated complex head domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    21962279..21990183 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)