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Eif4e2 eukaryotic translation initiation factor 4E member 2 [ Mus musculus (house mouse) ]

Gene ID: 26987, updated on 22-Jan-2023

Summary

Official Symbol
Eif4e2provided by MGI
Official Full Name
eukaryotic translation initiation factor 4E member 2provided by MGI
Primary source
MGI:MGI:1914440
See related
Ensembl:ENSMUSG00000026254 AllianceGenome:MGI:1914440
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eif4el3; D0H0S6743E; 2700069E09Rik
Summary
Predicted to enable RNA 7-methylguanosine cap binding activity; translation initiation factor activity; and ubiquitin protein ligase binding activity. Acts upstream of or within in utero embryonic development. Predicted to be located in P-body. Predicted to be part of eukaryotic translation initiation factor 4F complex and mRNA cap binding activity complex. Is expressed in early conceptus; embryo; primary oocyte; and secondary oocyte. Orthologous to human EIF4E2 (eukaryotic translation initiation factor 4E family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 12.5), placenta adult (RPKM 6.8) and 28 other tissues See more
Orthologs
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Genomic context

See Eif4e2 in Genome Data Viewer
Location:
1; 1 C5
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (87141633..87168210)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (87213911..87240488)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene cholinergic receptor, nicotinic, delta polypeptide Neighboring gene cholinergic receptor, nicotinic, gamma polypeptide Neighboring gene predicted gene, 53571 Neighboring gene predicted gene, 26187 Neighboring gene EF hand domain containing 1 Neighboring gene predicted gene, 41911

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA 7-methylguanosine cap binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in P-body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of eukaryotic translation initiation factor 4F complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of mRNA cap binding complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
eukaryotic translation initiation factor 4E type 2
Names
eIF-4E type 2
eIF4E type 2
eIF4E-2
eIF4E-like protein 4E-LP
eukaryotic translation initiation factor 4E like 3
mRNA cap-binding protein type 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039169.1NP_001034258.1  eukaryotic translation initiation factor 4E type 2 isoform 2

    See identical proteins and their annotated locations for NP_001034258.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of the first exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC102611, AK017221
    Consensus CDS
    CCDS15131.1
    UniProtKB/TrEMBL
    A0A8C6G6X6, Q0P688
    Related
    ENSMUSP00000108857.4, ENSMUST00000113231.4
    Conserved Domains (1) summary
    pfam01652
    Location:50208
    IF4E; Eukaryotic initiation factor 4E
  2. NM_001039170.1NP_001034259.1  eukaryotic translation initiation factor 4E type 2 isoform 1

    See identical proteins and their annotated locations for NP_001034259.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC102611, AK032965
    Consensus CDS
    CCDS35652.1
    UniProtKB/Swiss-Prot
    Q3UCK2, Q8BMB3
    Related
    ENSMUSP00000108859.2, ENSMUST00000113233.8
    Conserved Domains (1) summary
    pfam01652
    Location:55213
    IF4E; Eukaryotic initiation factor 4E
  3. NM_001347083.1NP_001334012.1  eukaryotic translation initiation factor 4E type 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC102611
    Consensus CDS
    CCDS83571.1
    UniProtKB/TrEMBL
    A0A8C6G712, D3Z729
    Related
    ENSMUSP00000108861.2, ENSMUST00000113235.8
    Conserved Domains (1) summary
    pfam01652
    Location:55213
    IF4E; Eukaryotic initiation factor 4E
  4. NM_023314.3NP_075803.2  eukaryotic translation initiation factor 4E type 2 isoform 3

    See identical proteins and their annotated locations for NP_075803.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 3'-most exon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC102611, AK032965, AK076067
    Consensus CDS
    CCDS15130.1
    UniProtKB/Swiss-Prot
    Q8BMB3
    UniProtKB/TrEMBL
    G3X9H1
    Related
    ENSMUSP00000075699.6, ENSMUST00000076362.12
    Conserved Domains (1) summary
    pfam01652
    Location:55213
    IF4E; Eukaryotic initiation factor 4E

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    87141633..87168210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165581.1XP_036021474.1  eukaryotic translation initiation factor 4E type 2 isoform X1

    Conserved Domains (1) summary
    pfam01652
    Location:55214
    IF4E; Eukaryotic initiation factor 4E
  2. XM_036165586.1XP_036021479.1  eukaryotic translation initiation factor 4E type 2 isoform X3

    Conserved Domains (1) summary
    pfam01652
    Location:55214
    IF4E; Eukaryotic initiation factor 4E
  3. XM_006529674.4XP_006529737.1  eukaryotic translation initiation factor 4E type 2 isoform X7

    UniProtKB/TrEMBL
    A0A8C6G6J5, D3YUV9
    Related
    ENSMUSP00000053403.8, ENSMUST00000050876.14
    Conserved Domains (1) summary
    pfam01652
    Location:55214
    IF4E; Eukaryotic initiation factor 4E
  4. XM_030254746.1XP_030110606.1  eukaryotic translation initiation factor 4E type 2 isoform X5

    UniProtKB/TrEMBL
    A0A8C6G6Y9
    Conserved Domains (1) summary
    pfam01652
    Location:50209
    IF4E; Eukaryotic initiation factor 4E
  5. XM_030254745.1XP_030110605.1  eukaryotic translation initiation factor 4E type 2 isoform X4

    Conserved Domains (1) summary
    pfam01652
    Location:50209
    IF4E; Eukaryotic initiation factor 4E
  6. XM_036165583.1XP_036021476.1  eukaryotic translation initiation factor 4E type 2 isoform X2

    Conserved Domains (1) summary
    pfam01652
    Location:50209
    IF4E; Eukaryotic initiation factor 4E
  7. XM_036165589.1XP_036021482.1  eukaryotic translation initiation factor 4E type 2 isoform X6

    Conserved Domains (1) summary
    pfam01652
    Location:50209
    IF4E; Eukaryotic initiation factor 4E

RNA

  1. XR_004942584.1 RNA Sequence