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EIF4E2 eukaryotic translation initiation factor 4E family member 2 [ Homo sapiens (human) ]

Gene ID: 9470, updated on 2-Nov-2024

Summary

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Official Symbol
EIF4E2provided by HGNC
Official Full Name
eukaryotic translation initiation factor 4E family member 2provided by HGNC
Primary source
HGNC:HGNC:3293
See related
Ensembl:ENSG00000135930 MIM:605895; AllianceGenome:HGNC:3293
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
4EHP; IF4e; 4E-LP; h4EHP; EIF4EL3
Summary
Enables RNA 7-methylguanosine cap binding activity; mRNA cap binding activity; and ubiquitin protein ligase binding activity. Involved in negative regulation of translational initiation; negative regulation of type I interferon-mediated signaling pathway; and rescue of stalled ribosome. Acts upstream of with a positive effect on miRNA-mediated gene silencing by inhibition of translation. Acts upstream of or within negative regulation of translation. Located in P-body. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in kidney (RPKM 16.4), colon (RPKM 13.5) and 25 other tissues See more
Orthologs
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Genomic context

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See EIF4E2 in Genome Data Viewer
Location:
2q37.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (232550689..232583644)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (233037473..233070437)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (233415399..233448354)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17323 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12460 Neighboring gene cholinergic receptor nicotinic gamma subunit Neighboring gene tigger transposable element derived 1 Neighboring gene microRNA 5001 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:233432608-233433807 Neighboring gene uncharacterized LOC105373929 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233465129-233465628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17324 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17325 Neighboring gene EF-hand domain family member D1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12461 Neighboring gene Sharpr-MPRA regulatory region 9991 Neighboring gene RNA, 7SL, cytoplasmic 359, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233526805-233527304 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein. Rom E, et al. J Biol Chem, 1998 May 22. PMID 9582349
  2. MicroRNAs recruit eIF4E2 to repress translation of target mRNAs. Chen S, et al. Protein Cell, 2017 Oct. PMID 28755203, Free PMC Article
  3. High EIF4E2 expression is an independent prognostic risk factor for poor overall survival and recurrence-free survival in uveal melanoma. Yang B, et al. Exp Eye Res, 2021 May. PMID 33785306
  4. Cancer cells exploit eIF4E2-directed synthesis of hypoxia response proteins to drive tumor progression. Uniacke J, et al. Cancer Res, 2014 Mar 1. PMID 24408918
  5. Weak binding affinity of human 4EHP for mRNA cap analogs. Zuberek J, et al. RNA, 2007 May. PMID 17369309, Free PMC Article

See all (116) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. METTL16 promotes translation and lung tumorigenesis by sequestering cytoplasmic eIF4E2.
    Title: METTL16 promotes translation and lung tumorigenesis by sequestering cytoplasmic eIF4E2.
  2. Translational repression of NMD targets by GIGYF2 and EIF4E2.
    Title: Translational repression of NMD targets by GIGYF2 and EIF4E2.
  3. 4EHP and GIGYF1/2 Mediate Translation-Coupled Messenger RNA Decay.
    Title: 4EHP and GIGYF1/2 Mediate Translation-Coupled Messenger RNA Decay.
  4. High EIF4E2 expression is an independent prognostic risk factor for poor overall survival and recurrence-free survival in uveal melanoma.
    Title: High EIF4E2 expression is an independent prognostic risk factor for poor overall survival and recurrence-free survival in uveal melanoma.
  5. microRNA-induced translational control of antiviral immunity by the cap-binding protein 4EHP.
    Title: microRNA-induced translational control of antiviral immunity by the cap-binding protein 4EHP.
  6. GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control.
    Title: GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control.
  7. The authors that the Dusp6 mRNA, which encodes an ERK1/2 phosphatase, is translationally repressed by 4EHP and a specific miRNA, miR-145.
    Title: Translational control of ERK signaling through miRNA/4EHP-directed silencing.
  8. cadherin-22 is upregulated in hypoxia via mTORC1-independent translational control by the initiation factor eIF4E2 functioning as a hypoxia-specific cell-surface molecule involved in cancer cell migration, invasion and adhesion.
    Title: Hypoxia activates cadherin-22 synthesis via eIF4E2 to drive cancer cell migration, invasion and adhesion.
  9. cap-binding activity contributes to the translational silencing by miRNAs through the CCR4-NOT complex
    Title: Cap-binding protein 4EHP effects translation silencing by microRNAs.
  10. We performed bioinformatics analyses of ESTs and the 3'UTRs of the main transcript splice variants of the translational initiation factor eIF4E1 and its family members, eIF4E2 and eIF4E3. We propose to elucidate the minor splice variants of eIF4E2 and eIF4E3 in great detail because they might produce proteins with modified features that fulfill different cellular roles from their major counterparts.
    Title: Major splice variants and multiple polyadenylation site utilization in mRNAs encoding human translation initiation factors eIF4E1 and eIF4E3 regulate the translational regulators?
Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study on overall survival of advanced non-small cell lung cancer patients treated with carboplatin and paclitaxel.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23586

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA 7-methylguanosine cap binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA 7-methylguanosine cap binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding HDA PubMed 
enables RNA cap binding TAS
Traceable Author Statement
more info
 PubMed 
enables mRNA cap binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation factor activity, RNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_positive_effect miRNA-mediated gene silencing by inhibition of translation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of type I interferon-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rescue of stalled ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of eukaryotic translation initiation factor 4F complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 4E type 2
Names
eIF-4E type 2
eIF4E-like cap-binding protein
eIF4E-like protein 4E-LP
eukaryotic translation initiation factor 4E homologous protein
eukaryotic translation initiation factor 4E-like 3
mRNA cap-binding protein type 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276336.2 → NP_001263265.1  eukaryotic translation initiation factor 4E type 2 isoform C

    See identical proteins and their annotated locations for NP_001263265.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 3' terminal exon and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (C) has a distinct C-terminus and is shorter than isoform A.
    Source sequence(s)
    AB209519, AK027239, DA201209, DA592245
    Consensus CDS
    CCDS63159.1
    UniProtKB/TrEMBL
    Q59FE1
    Related
    ENSP00000386996.1, ENST00000409098.5
    Conserved Domains (1) summary
    pfam01652
    Location:55 → 214
    IF4E; Eukaryotic initiation factor 4E

  2. NM_001276337.2 → NP_001263266.1  eukaryotic translation initiation factor 4E type 2 isoform D

    See identical proteins and their annotated locations for NP_001263266.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, and uses an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (D) has a distinct C-terminus and is shorter than isoform A.
    Source sequence(s)
    AB209519, AK027239, CD684451, DA201209, DA592245, DA992544
    Consensus CDS
    CCDS74671.1
    UniProtKB/TrEMBL
    B4E1E4, B9A023
    Related
    ENSP00000386983.1, ENST00000409394.5
    Conserved Domains (1) summary
    pfam01652
    Location:46 → 169
    IF4E; Eukaryotic initiation factor 4E

  3. NM_001282958.2 → NP_001269887.1  eukaryotic translation initiation factor 4E type 2 isoform B

    See identical proteins and their annotated locations for NP_001269887.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains alternate 3' exon structure and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (B) has a distinct C-terminus and is shorter than isoform A.
    Source sequence(s)
    AB209519, AK027239, BG913475, DA201209, DA408433, DA592245
    Consensus CDS
    CCDS63158.1
    UniProtKB/TrEMBL
    B8ZZ50, B9A044
    Related
    ENSP00000387336.1, ENST00000409514.5
    Conserved Domains (1) summary
    pfam01652
    Location:55 → 214
    IF4E; Eukaryotic initiation factor 4E

  4. NM_001330201.2 → NP_001317130.1  eukaryotic translation initiation factor 4E type 2 isoform E

    Status: VALIDATED

    Source sequence(s)
    AC092165, AC093383
    Consensus CDS
    CCDS82579.1
    UniProtKB/TrEMBL
    B4E1E4, B8ZZL3
    Related
    ENSP00000386424.1, ENST00000409322.5
    Conserved Domains (1) summary
    pfam01652
    Location:46 → 169
    IF4E; Eukaryotic initiation factor 4E

  5. NM_001330202.2 → NP_001317131.1  eukaryotic translation initiation factor 4E type 2 isoform G

    Status: VALIDATED

    Source sequence(s)
    AC092165, AC093383
    UniProtKB/TrEMBL
    C9JEL3
    Related
    ENSP00000390904.1, ENST00000454501.1
    Conserved Domains (1) summary
    pfam01652
    Location:50 → 209
    IF4E; Eukaryotic initiation factor 4E

  6. NM_001330203.2 → NP_001317132.1  eukaryotic translation initiation factor 4E type 2 isoform F

    Status: VALIDATED

    Source sequence(s)
    AC073254, AC092165
    Consensus CDS
    CCDS92971.1
    UniProtKB/TrEMBL
    A0A8I5KSA5, B4E1E4
    Related
    ENSP00000508671.1, ENST00000687222.1
    Conserved Domains (1) summary
    pfam01652
    Location:46 → 169
    IF4E; Eukaryotic initiation factor 4E

  7. NM_004846.4 → NP_004837.1  eukaryotic translation initiation factor 4E type 2 isoform A

    See identical proteins and their annotated locations for NP_004837.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (A).
    Source sequence(s)
    BC005874
    Consensus CDS
    CCDS2496.1
    UniProtKB/Swiss-Prot
    B8ZZJ9, O60573, O75349
    UniProtKB/TrEMBL
    B9A044, Q53RG0
    Related
    ENSP00000258416.3, ENST00000258416.8
    Conserved Domains (1) summary
    pfam01652
    Location:55 → 214
    IF4E; Eukaryotic initiation factor 4E

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    232550689..232583644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    233037473..233070437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O60573.1 GenPept UniProtKB/Swiss-Prot:O60573

Gene LinkOut

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