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Zfp384 zinc finger protein 384 [ Mus musculus (house mouse) ]

Gene ID: 269800, updated on 17-Aug-2024

Summary

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Official Symbol
Zfp384provided by MGI
Official Full Name
zinc finger protein 384provided by MGI
Primary source
MGI:MGI:2443203
See related
Ensembl:ENSMUSG00000038346 AllianceGenome:MGI:2443203
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NP; Ciz; Nmp4; C130073D16Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SH3 domain binding activity. Predicted to be involved in nucleocytoplasmic transport; positive regulation of protein secretion; and positive regulation of transcription by RNA polymerase II. Predicted to be located in focal adhesion and nucleus. Is expressed in genitourinary system. Orthologous to human ZNF384 (zinc finger protein 384). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 25.8), thymus adult (RPKM 24.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp384 in Genome Data Viewer
Location:
6 F2; 6 59.17 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (124985980..125014833)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (125009017..125037870)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3682 Neighboring gene COP9 signalosome subunit 7A Neighboring gene predicted gene, 23851 Neighboring gene STARR-seq mESC enhancer starr_17320 Neighboring gene STARR-seq mESC enhancer starr_17322 Neighboring gene PILR alpha associated neural protein Neighboring gene STARR-positive B cell enhancer ABC_E6488 Neighboring gene STARR-positive B cell enhancer ABC_E1711 Neighboring gene RIKEN cDNA 4930557K07 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124959611-124959720 Neighboring gene STARR-positive B cell enhancer ABC_E1071 Neighboring gene STARR-seq mESC enhancer starr_17323 Neighboring gene STARR-positive B cell enhancer ABC_E6489 Neighboring gene inhibitor of growth family, member 4 Neighboring gene proacrosin binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NMP4 regulates the innate immune response to influenza A virus infection. Yang S, et al. Mucosal Immunol, 2021 Jan. PMID 32152414, Free PMC Article
  2. Loss of Nmp4 optimizes osteogenic metabolism and secretion to enhance bone quality. Shao Y, et al. Am J Physiol Endocrinol Metab, 2019 May 1. PMID 30645175, Free PMC Article
  3. Improving Combination Osteoporosis Therapy in a Preclinical Model of Heightened Osteoanabolism. Shao Y, et al. Endocrinology, 2017 Sep 1. PMID 28637206, Free PMC Article
  4. Nmp4/CIZ suppresses the parathyroid hormone anabolic window by restricting mesenchymal stem cell and osteoprogenitor frequency. He Y, et al. Stem Cells Dev, 2013 Feb 1. PMID 22873745, Free PMC Article
  5. Nmp4/CIZ inhibits mechanically induced beta-catenin signaling activity in osteoblasts. Yang Z, et al. J Cell Physiol, 2010 May. PMID 20112285, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Conditional Loss of Nmp4 in Mesenchymal Stem Progenitor Cells Enhances PTH-Induced Bone Formation.
    Title: Conditional Loss of Nmp4 in Mesenchymal Stem Progenitor Cells Enhances PTH-Induced Bone Formation.
  2. NMP4 regulates the innate immune response to influenza A virus infection.
    Title: NMP4 regulates the innate immune response to influenza A virus infection.
  3. loss of Nmp4 increases the magnitude of glycolysis upon the metabolic switch, which fuels the conversion of the osteoblast into a super-secretor of matrix resulting in more bone with improvements in intrinsic quality.
    Title: Loss of Nmp4 optimizes osteogenic metabolism and secretion to enhance bone quality.
  4. The heightened osteoanabolism of the Nmp4-/- skeleton enhances the effectiveness of diverse osteoporosis treatments, in part by increasing hyperanabolic osteoprogenitors. Nmp4 provides a promising target pathway for identifying barriers to pharmacologically induced bone formation.
    Title: Improving Combination Osteoporosis Therapy in a Preclinical Model of Heightened Osteoanabolism.
  5. Sustained protein synthesis sensitized cells to pharmacological induction of the Unfolded Protein Response (UPR), and the observed decrease in cell viability was restored upon inhibition of GADD34 activity. We conclude that NMP4 is a key regulator of ribosome biogenesis and the UPR, which together play a central role in determining cell viability during endoplasmic reticulum stress.
    Title: Nuclear Matrix Protein 4 Is a Novel Regulator of Ribosome Biogenesis and Controls the Unfolded Protein Response via Repression of Gadd34 Expression.
  6. NMP4 deficiency suppressed the arthritis-induced increase in bone resorption, expression of RANKL and MMP-3 mRNA.
    Title: Mice Deficient in CIZ/NMP4 Develop an Attenuated Form of K/BxN-Serum Induced Arthritis.
  7. Nmp4/CIZ limits the parathyroid hormone anabolic window by restricting the number of bone marrow stem, progenitor, and blood cells that support anabolic bone remodeling.
    Title: Nmp4/CIZ suppresses the parathyroid hormone anabolic window by restricting mesenchymal stem cell and osteoprogenitor frequency.
  8. The CIZ/NMP4 expression levels are correlated to the metastatic activity in divergent types of melanoma cells.
    Title: CIZ/NMP4 is expressed in B16 melanoma and forms a positive feedback loop with RANKL to promote migration of the melanoma cells.
  9. Together these results provide experimental support for the concept that Nmp4/CIZ plays an inhibitory role in the response of bone cells to mechanical stimulation induced by OFSS.
    Title: Nmp4/CIZ inhibits mechanically induced beta-catenin signaling activity in osteoblasts.
  10. Nmp4/CIZ within the context of the PTH-induced anabolic response is described.
    Title: Nmp4/CIZ: road block at the intersection of PTH and load.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in nucleocytoplasmic transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 384
Names
nuclear matrix protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252083.1 → NP_001239012.1  zinc finger protein 384 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC134529, AC164563, BY595967
    Consensus CDS
    CCDS57448.1
    UniProtKB/TrEMBL
    A0AA74KTG5, E9Q8N7, E9QAR1
    Related
    ENSMUSP00000108047.2, ENSMUST00000112428.8
    Conserved Domains (4) summary
    COG5048
    Location:285 → 426
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290 → 310
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:288 → 310
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:330 → 357
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001347452.1 → NP_001334381.1  zinc finger protein 384 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC134529, AC164563
    Consensus CDS
    CCDS90119.1
    UniProtKB/TrEMBL
    A0AA74KTG5, E9QAR4
    Conserved Domains (2) summary
    COG5048
    Location:209 → 395
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259 → 279
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001372420.1 → NP_001359349.1  zinc finger protein 384 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC134529, AC164563
    UniProtKB/TrEMBL
    Q6P3F1
    Conserved Domains (2) summary
    COG5048
    Location:285 → 440
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:351 → 371
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001372422.1 → NP_001359351.1  zinc finger protein 384 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC134529, AC164563
    Consensus CDS
    CCDS39631.1
    UniProtKB/TrEMBL
    E9Q1A5, Q6P3F1
    Related
    ENSMUSP00000108046.2, ENSMUST00000112427.8
    Conserved Domains (2) summary
    COG5048
    Location:209 → 409
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:320 → 340
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_001372424.1 → NP_001359353.1  zinc finger protein 384 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC134529, AC164563
    Consensus CDS
    CCDS39631.1
    UniProtKB/TrEMBL
    E9Q1A5, Q6P3F1
    Conserved Domains (2) summary
    COG5048
    Location:209 → 409
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:320 → 340
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. NM_175557.5 → NP_780766.3  zinc finger protein 384 isoform 1

    See identical proteins and their annotated locations for NP_780766.3

    Status: VALIDATED

    Source sequence(s)
    AC134529, AC164563, BB662626, BY261721, BY595967
    Consensus CDS
    CCDS39631.1
    UniProtKB/TrEMBL
    E9Q1A5, Q6P3F1
    Related
    ENSMUSP00000081296.6, ENSMUST00000084275.12
    Conserved Domains (2) summary
    COG5048
    Location:209 → 409
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:320 → 340
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    124985980..125014833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506201.3 → XP_006506264.1  zinc finger protein 384 isoform X1

    See identical proteins and their annotated locations for XP_006506264.1

    UniProtKB/TrEMBL
    Q6P3F1
    Conserved Domains (2) summary
    COG5048
    Location:285 → 440
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:351 → 371
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_006506204.4 → XP_006506267.1  zinc finger protein 384 isoform X6

    UniProtKB/TrEMBL
    A0AA74KTG5, E9QAR4
    Conserved Domains (2) summary
    COG5048
    Location:209 → 395
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259 → 279
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_036166185.1 → XP_036022078.1  zinc finger protein 384 isoform X6

    UniProtKB/TrEMBL
    A0AA74KTG5, E9QAR4
    Conserved Domains (2) summary
    COG5048
    Location:209 → 395
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259 → 279
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_036166189.1 → XP_036022082.1  zinc finger protein 384 isoform X9

    Conserved Domains (2) summary
    COG5048
    Location:64 → 264
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:175 → 195
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_036166186.1 → XP_036022079.1  zinc finger protein 384 isoform X7

    UniProtKB/TrEMBL
    D3YX49
    Related
    ENSMUSP00000086354.3, ENSMUST00000054553.11
    Conserved Domains (4) summary
    COG5048
    Location:193 → 379
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:243 → 263
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:241 → 263
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:283 → 310
    zf-H2C2_2; Zinc-finger double domain

  6. XM_036166187.1 → XP_036022080.1  zinc finger protein 384 isoform X9

    Conserved Domains (2) summary
    COG5048
    Location:64 → 264
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:175 → 195
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. XM_030255423.1 → XP_030111283.1  zinc finger protein 384 isoform X8

    Conserved Domains (2) summary
    COG5048
    Location:140 → 295
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:206 → 226
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. XM_036166190.1 → XP_036022083.1  zinc finger protein 384 isoform X10

    Conserved Domains (2) summary
    COG5048
    Location:140 → 281
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:145 → 165
    ZF_C2H2; C2H2 Zn finger [structural motif]

  9. XM_036166191.1 → XP_036022084.1  zinc finger protein 384 isoform X11

    Conserved Domains (2) summary
    COG5048
    Location:64 → 250
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:114 → 134
    ZF_C2H2; C2H2 Zn finger [structural motif]

  10. XM_030255424.1 → XP_030111284.1  zinc finger protein 384 isoform X12

    Conserved Domains (3) summary
    COG5048
    Location:22 → 177
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:138 → 190
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:88 → 108
    ZF_C2H2; C2H2 Zn finger [structural motif]

  11. XM_006506202.3 → XP_006506265.1  zinc finger protein 384 isoform X2

    UniProtKB/TrEMBL
    Q6P3F1
    Conserved Domains (2) summary
    COG5048
    Location:269 → 424
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:335 → 355
    ZF_C2H2; C2H2 Zn finger [structural motif]

  12. XM_036166183.1 → XP_036022076.1  zinc finger protein 384 isoform X5

    UniProtKB/TrEMBL
    A0AA74KTG5
    Conserved Domains (4) summary
    COG5048
    Location:269 → 410
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:274 → 294
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:272 → 294
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:314 → 341
    zf-H2C2_2; Zinc-finger double domain

  13. XM_030255421.1 → XP_030111281.1  zinc finger protein 384 isoform X3

    UniProtKB/TrEMBL
    E9QAR6, Q6P3F1
    Related
    ENSMUSP00000108043.2, ENSMUST00000112424.2
    Conserved Domains (2) summary
    COG5048
    Location:193 → 393
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:304 → 324
    ZF_C2H2; C2H2 Zn finger [structural motif]

  14. XM_006506205.5 → XP_006506268.1  zinc finger protein 384 isoform X8

    Conserved Domains (2) summary
    COG5048
    Location:140 → 295
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:206 → 226
    ZF_C2H2; C2H2 Zn finger [structural motif]

  15. XM_036166188.1 → XP_036022081.1  zinc finger protein 384 isoform X9

    Conserved Domains (2) summary
    COG5048
    Location:64 → 264
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:175 → 195
    ZF_C2H2; C2H2 Zn finger [structural motif]

  16. XM_036166192.1 → XP_036022085.1  zinc finger protein 384 isoform X11

    Conserved Domains (2) summary
    COG5048
    Location:64 → 250
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:114 → 134
    ZF_C2H2; C2H2 Zn finger [structural motif]

  17. XM_030255425.2 → XP_030111285.1  zinc finger protein 384 isoform X12

    Conserved Domains (3) summary
    COG5048
    Location:22 → 177
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:138 → 190
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:88 → 108
    ZF_C2H2; C2H2 Zn finger [structural motif]

  18. XM_006506200.5 → XP_006506263.1  zinc finger protein 384 isoform X1

    See identical proteins and their annotated locations for XP_006506263.1

    UniProtKB/TrEMBL
    Q6P3F1
    Conserved Domains (2) summary
    COG5048
    Location:285 → 440
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:351 → 371
    ZF_C2H2; C2H2 Zn finger [structural motif]

  19. XM_036166182.1 → XP_036022075.1  zinc finger protein 384 isoform X4

    UniProtKB/TrEMBL
    A0AA74KTG5, E9Q8N7, E9QAR1
    Related
    ENSMUSP00000037986.11, ENSMUST00000046064.17
    Conserved Domains (4) summary
    COG5048
    Location:285 → 426
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290 → 310
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:288 → 310
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:330 → 357
    zf-H2C2_2; Zinc-finger double domain

  20. XM_036166193.1 → XP_036022086.1  zinc finger protein 384 isoform X12

    Conserved Domains (3) summary
    COG5048
    Location:22 → 177
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:138 → 190
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:88 → 108
    ZF_C2H2; C2H2 Zn finger [structural motif]

  21. XM_036166184.1 → XP_036022077.1  zinc finger protein 384 isoform X6

    UniProtKB/TrEMBL
    A0AA74KTG5, E9QAR4
    Related
    ENSMUSP00000108044.2, ENSMUST00000112425.8
    Conserved Domains (2) summary
    COG5048
    Location:209 → 395
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259 → 279
    ZF_C2H2; C2H2 Zn finger [structural motif]

  22. XM_030255419.2 → XP_030111279.1  zinc finger protein 384 isoform X2

    UniProtKB/TrEMBL
    Q6P3F1
    Conserved Domains (2) summary
    COG5048
    Location:269 → 424
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:335 → 355
    ZF_C2H2; C2H2 Zn finger [structural motif]

  23. XM_030255422.2 → XP_030111282.1  zinc finger protein 384 isoform X3

    UniProtKB/TrEMBL
    E9QAR6, Q6P3F1
    Conserved Domains (2) summary
    COG5048
    Location:193 → 393
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:304 → 324
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
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